{"id":"https://openalex.org/W2189787879","doi":"https://doi.org/10.1189/jlb.1ri0815-389r","title":"Long noncoding RNAs in T lymphocytes","display_name":"Long noncoding RNAs in T lymphocytes","publication_year":2015,"publication_date":"2015-11-04","ids":{"openalex":"https://openalex.org/W2189787879","doi":"https://doi.org/10.1189/jlb.1ri0815-389r","mag":"2189787879","pmid":"https://pubmed.ncbi.nlm.nih.gov/26538526","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608032"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.1ri0815-389r","doi":"https://doi.org/10.1189/jlb.1ri0815-389r","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.1ri0815-389r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608032","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026728364","display_name":"Thomas M. Aune","orcid":"https://orcid.org/0000-0002-4968-4306","observed_orcids":["https://orcid.org/0000-0002-4968-4306"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas M Aune","raw_affiliation_strings":["Department of Medicine , Nashville, Tennessee , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine , Nashville, Tennessee , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056838759","display_name":"Philip S. Crooke","orcid":"https://orcid.org/0000-0003-3872-3290","observed_orcids":["https://orcid.org/0000-0003-3872-3290"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip S Crooke","raw_affiliation_strings":["Department of Mathematics, Vanderbilt University , Nashville, Tennessee , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Vanderbilt University , Nashville, Tennessee , USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036914251","display_name":"Charles F. Spurlock","orcid":"https://orcid.org/0000-0001-9015-6321","observed_orcids":["https://orcid.org/0000-0001-9015-6321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles F Spurlock","raw_affiliation_strings":["Department of Medicine , Nashville, Tennessee , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine , Nashville, Tennessee , USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026728364"],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.5507,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.48406863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"99","issue":"1","first_page":"31","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.7990000247955322},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.9890000224113464},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9211115837097168},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.5711855292320251},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4549108147621155},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.42808935046195984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4254993796348572},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40290433168411255},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34238600730895996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29903560876846313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19457653164863586}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1189/jlb.1ri0815-389r","doi":"https://doi.org/10.1189/jlb.1ri0815-389r","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.1ri0815-389r","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5590107","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6608032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608032","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},{"id":"pmid:26538526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26538526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5590107","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3641704770","display_name":"IFN-Gamma Gene Regulation in T Cells and NK Cells","funder_award_id":"R01AI044924","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6762771772","display_name":null,"funder_award_id":"DGE0909667","funder_id":"https://openalex.org/F4562087700","funder_display_name":"National Science Foundation Graduate Research Fellowship Program"},{"id":"https://openalex.org/G7966534474","display_name":"Cell cycle checkpoint defects lead to chronic inflammation in RA","funder_award_id":"R21AR063846","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4562087700","display_name":"National Science Foundation Graduate Research Fellowship Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W778623635","https://openalex.org/W1509094659","https://openalex.org/W1509892500","https://openalex.org/W1612748954","https://openalex.org/W1661896406","https://openalex.org/W1749022239","https://openalex.org/W1929978039","https://openalex.org/W1964113455","https://openalex.org/W1975847255","https://openalex.org/W1976067040","https://openalex.org/W1977751039","https://openalex.org/W1977937947","https://openalex.org/W1977943782","https://openalex.org/W1979768717","https://openalex.org/W1979906868","https://openalex.org/W1985293294","https://openalex.org/W1986705163","https://openalex.org/W1989367702","https://openalex.org/W1993467866","https://openalex.org/W1995852794","https://openalex.org/W1999746344","https://openalex.org/W2001206796","https://openalex.org/W2002307060","https://openalex.org/W2002740312","https://openalex.org/W2005281324","https://openalex.org/W2006358633","https://openalex.org/W2007071422","https://openalex.org/W2008243402","https://openalex.org/W2009893780","https://openalex.org/W2012825693","https://openalex.org/W2016302314","https://openalex.org/W2017037510","https://openalex.org/W2017538897","https://openalex.org/W2019155483","https://openalex.org/W2021341670","https://openalex.org/W2021880506","https://openalex.org/W2027699534","https://openalex.org/W2028866897","https://openalex.org/W2032183472","https://openalex.org/W2032406291","https://openalex.org/W2033505817","https://openalex.org/W2035242839","https://openalex.org/W2044806644","https://openalex.org/W2044910962","https://openalex.org/W2048194168","https://openalex.org/W2054542819","https://openalex.org/W2055521085","https://openalex.org/W2056198580","https://openalex.org/W2058615001","https://openalex.org/W2066197777","https://openalex.org/W2068209691","https://openalex.org/W2071849521","https://openalex.org/W2072451938","https://openalex.org/W2072506120","https://openalex.org/W2073026107","https://openalex.org/W2073136316","https://openalex.org/W2079588819","https://openalex.org/W2083987270","https://openalex.org/W2085364628","https://openalex.org/W2087377443","https://openalex.org/W2093648203","https://openalex.org/W2095739285","https://openalex.org/W2096394186","https://openalex.org/W2098972920","https://openalex.org/W2100305481","https://openalex.org/W2102304447","https://openalex.org/W2102649026","https://openalex.org/W2105122178","https://openalex.org/W2105349784","https://openalex.org/W2109450380","https://openalex.org/W2110456739","https://openalex.org/W2110905563","https://openalex.org/W2111825647","https://openalex.org/W2114104545","https://openalex.org/W2117131162","https://openalex.org/W2119828270","https://openalex.org/W2121394859","https://openalex.org/W2121828161","https://openalex.org/W2122210168","https://openalex.org/W2122810813","https://openalex.org/W2124097252","https://openalex.org/W2127230663","https://openalex.org/W2129304835","https://openalex.org/W2134033103","https://openalex.org/W2135621733","https://openalex.org/W2136120736","https://openalex.org/W2137840425","https://openalex.org/W2138884188","https://openalex.org/W2139658526","https://openalex.org/W2140729960","https://openalex.org/W2141831115","https://openalex.org/W2142813932","https://openalex.org/W2143393352","https://openalex.org/W2144137532","https://openalex.org/W2144625075","https://openalex.org/W2146573461","https://openalex.org/W2147568705","https://openalex.org/W2149548305","https://openalex.org/W2150098952","https://openalex.org/W2151010498","https://openalex.org/W2152869198","https://openalex.org/W2153268494","https://openalex.org/W2156392314","https://openalex.org/W2160333540","https://openalex.org/W2161913720","https://openalex.org/W2165460636","https://openalex.org/W2166810745","https://openalex.org/W2166820820","https://openalex.org/W2166967514","https://openalex.org/W2168612089","https://openalex.org/W2168909179","https://openalex.org/W2179438025","https://openalex.org/W7098463221"],"related_works":["https://openalex.org/W2549013197","https://openalex.org/W1976067040","https://openalex.org/W1612748954","https://openalex.org/W4244772221","https://openalex.org/W2486078685","https://openalex.org/W3112257838","https://openalex.org/W4379520143","https://openalex.org/W2012825693","https://openalex.org/W2030479443","https://openalex.org/W2528388077"],"abstract_inverted_index":{"Long":[0],"noncoding":[1,29,48,101,123],"RNAs":[2,49,102,124],"are":[3],"recently":[4],"discovered":[5],"regulatory":[6],"RNA":[7,30],"molecules":[8],"that":[9,46,59,120],"do":[10],"not":[11],"code":[12],"for":[13],"proteins":[14],"but":[15],"influence":[16],"a":[17],"vast":[18],"array":[19],"of":[20,27,39,63,73,87,89,92,118],"biologic":[21,52],"processes.":[22],"In":[23,78],"vertebrates,":[24],"the":[25,37,51,70,74,79,90,107,112,116],"number":[26,38],"long":[28,47,94,100,122],"genes":[31],"is":[32,43],"thought":[33,45],"to":[34,126],"greatly":[35],"exceed":[36],"protein-coding":[40],"genes.":[41],"It":[42],"also":[44],"drive":[50],"complexity":[53,65],"observed":[54],"in":[55,60,69,106,111,131,134],"vertebrates":[56],"compared":[57],"with":[58],"invertebrates.":[61],"Evidence":[62],"this":[64],"has":[66],"been":[67],"found":[68],"T-lymphocyte":[71,104,128],"compartment":[72],"adaptive":[75],"immune":[76],"system.":[77],"present":[80],"review,":[81],"we":[82],"describe":[83],"our":[84],"current":[85],"level":[86],"understanding":[88],"expression":[91],"specific":[93,121],"or":[95,98],"large":[96],"intergenic":[97],"intervening":[99],"during":[103],"development":[105],"thymus":[108],"and":[109,114,133],"differentiation":[110],"periphery":[113],"highlight":[115],"mechanisms":[117],"action":[119],"employ":[125],"regulate":[127],"function,":[129],"both":[130],"vitro":[132],"vivo.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
