{"id":"https://openalex.org/W2189694776","doi":"https://doi.org/10.1007/s40242-015-5202-3","title":"Synthesis, characterization and biological activity of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as epidermal growth factor receptor inhibitors","display_name":"Synthesis, characterization and biological activity of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as epidermal growth factor receptor inhibitors","publication_year":2015,"publication_date":"2015-11-04","ids":{"openalex":"https://openalex.org/W2189694776","doi":"https://doi.org/10.1007/s40242-015-5202-3","mag":"2189694776"},"language":"en","primary_location":{"id":"doi:10.1007/s40242-015-5202-3","doi":"https://doi.org/10.1007/s40242-015-5202-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40242-015-5202-3","pdf_url":null,"source":{"id":"https://openalex.org/S120870440","display_name":"Chemical Research in Chinese Universities","issn_l":"1005-9040","issn":["1005-9040","2210-3171"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Chinese Universities","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102722001","display_name":"Bing Sun","orcid":"https://orcid.org/0009-0009-2639-2237","observed_orcids":["https://orcid.org/0009-0009-2639-2237","https://orcid.org/0000-0002-1992-3767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Sun","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061721405","display_name":"Xiu\u2019e Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiu\u2019e Yin","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405947","display_name":"Jin Zhang","orcid":"https://orcid.org/0000-0002-2566-7501","observed_orcids":["https://orcid.org/0000-0002-2566-7501","https://orcid.org/0009-0000-3665-790X"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057147306","display_name":"Jian Yuan Huang","orcid":"https://orcid.org/0000-0002-1649-0038","observed_orcids":["https://orcid.org/0000-0002-1649-0038"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Huang","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102349177","display_name":"Yue Xu","orcid":"https://orcid.org/0009-0007-9234-209X","observed_orcids":["https://orcid.org/0009-0007-9234-209X","https://orcid.org/0009-0009-4955-135X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Xu","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101681457","display_name":"Furong Zhang","orcid":"https://orcid.org/0000-0002-4671-2295","observed_orcids":["https://orcid.org/0000-0002-4671-2295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Furong Zhang","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394111","display_name":"Jinhui Wang","orcid":"https://orcid.org/0000-0002-3499-4336","observed_orcids":["https://orcid.org/0000-0002-3499-4336"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinhui Wang","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034640763","display_name":"Guoqing qing Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoqing qing Wang","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055096641","display_name":"Chun Hu","orcid":"https://orcid.org/0000-0003-2919-2870","observed_orcids":["https://orcid.org/0000-0003-2919-2870"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chun Hu","raw_affiliation_strings":["Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang, 110016, P. R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055096641"],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":0.289,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.54258894,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"31","issue":"6","first_page":"936","last_page":"941"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/egfr-kinase-inhibitors","display_name":"EGFR kinase inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/a549-lung-carcinoma-cells","display_name":"A549 lung carcinoma cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8600000143051147},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.9190000295639038},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.7820000052452087},{"id":"https://openalex.org/keywords/piperidine-derivatives","display_name":"piperidine derivatives","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.8722081780433655},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.8048344254493713},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7450833320617676},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.687305212020874},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6584979295730591},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.5207898020744324},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5051954388618469},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4964640736579895},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45207950472831726},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4243793785572052},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4228527843952179},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.41623854637145996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3895801305770874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35028380155563354},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2745135426521301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1999017596244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10936254262924194},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s40242-015-5202-3","doi":"https://doi.org/10.1007/s40242-015-5202-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40242-015-5202-3","pdf_url":null,"source":{"id":"https://openalex.org/S120870440","display_name":"Chemical Research in Chinese Universities","issn_l":"1005-9040","issn":["1005-9040","2210-3171"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Chinese Universities","raw_type":"journal-article"},{"id":"mag:3143812655","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/86071X/201506/666988640.html","pdf_url":null,"source":{"id":"https://openalex.org/S120870440","display_name":"Chemical Research in Chinese Universities","issn_l":"1005-9040","issn":["1005-9040","2210-3171"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319972","host_organization_name":"Springer International Publishing","host_organization_lineage":["https://openalex.org/P4310319972","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer International Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u9ad8\u7b49\u5b66\u6821\u5316\u5b66\u7814\u7a76\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1575879145","https://openalex.org/W1653571790","https://openalex.org/W1832109065","https://openalex.org/W1974024530","https://openalex.org/W1979332174","https://openalex.org/W1995853598","https://openalex.org/W2002937040","https://openalex.org/W2007649418","https://openalex.org/W2027514622","https://openalex.org/W2028009636","https://openalex.org/W2042775074","https://openalex.org/W2043911313","https://openalex.org/W2049655823","https://openalex.org/W2050398644","https://openalex.org/W2100794900","https://openalex.org/W2133051701","https://openalex.org/W2138297714","https://openalex.org/W2150226936","https://openalex.org/W2151566058","https://openalex.org/W2168391786"],"related_works":["https://openalex.org/W4385978980","https://openalex.org/W2887268913","https://openalex.org/W2337170247","https://openalex.org/W7154620551","https://openalex.org/W4382011490","https://openalex.org/W2063130697","https://openalex.org/W4389068624","https://openalex.org/W2316776483","https://openalex.org/W2524297231","https://openalex.org/W7160232195"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
