{"id":"https://openalex.org/W2189608955","doi":null,"title":"Photoreceptor Recovery after Shorr-Term Detachment","display_name":"Photoreceptor Recovery after Shorr-Term Detachment","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2189608955","mag":"2189608955"},"language":"en","primary_location":{"id":"mag:2189608955","doi":null,"is_oa":false,"landing_page_url":"http://labs.mcdb.ucsb.edu/fisher/steven/pubs/Guerin,et-al.-1989.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059048068","display_name":"Christopher J. Gu\u00e9rin","orcid":"https://orcid.org/0000-0001-9535-8037","observed_orcids":["https://orcid.org/0000-0001-9535-8037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. Gu\u00e9rin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9535-8037","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103512361","display_name":"Don H. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Don H. Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007857364","display_name":"Robert N. Fariss","orcid":"https://orcid.org/0000-0003-3227-7170","observed_orcids":["https://orcid.org/0000-0003-3227-7170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert N. Fariss","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3227-7170","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108585423","display_name":"Steven K. Fisher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven K. Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13867308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.053700000047683716,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photoreceptor-regeneration","display_name":"photoreceptor regeneration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/retinal-detachment","display_name":"retinal detachment","score":0.8740000128746033},{"id":"https://openalex.org/keywords/retinal-reattachment","display_name":"retinal reattachment","score":0.8309999704360962},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cone-outer-segments","display_name":"cone outer segments","score":0.9990000128746033},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.8939999938011169},{"id":"https://openalex.org/keywords/opsin","display_name":"opsin","score":0.8029999732971191},{"id":"https://openalex.org/keywords/phagosome","display_name":"phagosome","score":0.8339999914169312},{"id":"https://openalex.org/keywords/macula","display_name":"macula","score":0.5889999866485596},{"id":"https://openalex.org/keywords/outer-segment-length","display_name":"outer segment length","score":0.43299999833106995},{"id":"https://openalex.org/keywords/subretinal-injection","display_name":"subretinal injection","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6590936183929443},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6428523063659668},{"id":"https://openalex.org/C2780428090","wikidata":"https://www.wikidata.org/wiki/Q625164","display_name":"Retinal detachment","level":3,"score":0.5798860788345337},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4425722658634186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3622398376464844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3587051033973694},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.34683746099472046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26543694734573364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2189608955","doi":null,"is_oa":false,"landing_page_url":"http://labs.mcdb.ucsb.edu/fisher/steven/pubs/Guerin,et-al.-1989.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W122777485","https://openalex.org/W163911440","https://openalex.org/W1534935441","https://openalex.org/W1554014071","https://openalex.org/W1578849205","https://openalex.org/W1970449835","https://openalex.org/W1976032516","https://openalex.org/W1993630505","https://openalex.org/W1995437367","https://openalex.org/W1998794025","https://openalex.org/W2001363728","https://openalex.org/W2023145760","https://openalex.org/W2050510075","https://openalex.org/W2054732202","https://openalex.org/W2071158957","https://openalex.org/W2086790354","https://openalex.org/W2130863893","https://openalex.org/W2151904681","https://openalex.org/W2154426161","https://openalex.org/W2166570689","https://openalex.org/W2202343186","https://openalex.org/W2220210862","https://openalex.org/W2417584815","https://openalex.org/W2419185298","https://openalex.org/W2766723043","https://openalex.org/W2778080704"],"related_works":["https://openalex.org/W1544920191","https://openalex.org/W2140413362","https://openalex.org/W122777485","https://openalex.org/W1534935441","https://openalex.org/W1494935408","https://openalex.org/W1492683389","https://openalex.org/W2114830150","https://openalex.org/W2169841969","https://openalex.org/W2088445772","https://openalex.org/W2015123573"],"abstract_inverted_index":{"The":[0,97,146,337],"macula":[1],"of":[2,25,52,94,141,162,205,277,297,303,311,325,340,351,358,363,371,379,387,417],"the":[3,16,33,42,119,139,142,152,170,268,278,304,309,316,347,364,372,377,385,404,415],"neural":[4],"retina":[5,143],"from":[6,15,41,75],"12":[7],"adult":[8],"rhesus":[9],"monkeys":[10],"(Macaca":[11],"mulatto)":[12],"was":[13,173,282,291],"detached":[14],"overlying":[17],"retinal":[18,329,382,405,421],"pigment":[19,406],"epithelium":[20,407],"(RPE)":[21,408],"by":[22,38,271],"subretinal":[23],"injection":[24,93],"a":[26,49,160,186,210,295],"balanced":[27],"salt":[28],"solution.":[29],"Seven":[30],"days":[31,65,68,79,84,157],"later,":[32],"two":[34],"layers":[35],"were":[36,59,99,111,219,234,244,265],"reapposed":[37],"draining":[39],"fluid":[40],"vitreous":[43],"cavity":[44],"and":[45,56,66,71,104,108,127,138,165,177,185,200,262,290,308,349,369,389,396],"replacing":[46],"it":[47],"with":[48,194,256,294,403],"3:1":[50],"mixture":[51],"sulphur":[53],"hexafluoride":[54],"gas":[55],"air.":[57],"Animals":[58],"sacrificed":[60],"at":[61,72,284],"1":[62,272],"hr,":[63],"2":[64],"7":[67],"after":[69,80,158,197,209,274,328,381,420],"detachment,":[70],"periods":[73],"ranging":[74],"3":[76,95,156],"to":[77,86,188,190,237,249,391,397],"14":[78],"reattachment.":[81,198,238,275,330,422],"At":[82,155],"2-7":[83],"prior":[85],"sacrifice,":[87],"some":[88,285],"eyes":[89,98],"received":[90],"an":[91,181,323,410],"intravitreal":[92],"H-L-fucose.":[96],"then":[100],"fixed":[101],"for":[102,113,346],"light":[103,352],"electron":[105],"microscopy":[106],"(EM),":[107],"tissue":[109],"sections":[110],"processed":[112],"autoradiography":[114],"(ARG)":[115],"or":[116,314],"immunocytochemistry.":[117],"During":[118],"7-day":[120],"detachment":[121,153,306],"interval,":[122,307],"rod":[123,241],"outer":[124,129,216,253,299,338,394],"segments":[125,130,135,254,339,395],"(ROSs)":[126],"cone":[128],"(COSs)":[131],"degenerated,":[132],"but":[133,169],"inner":[134],"remained":[136],"intact":[137],"rest":[140],"appeared":[144],"normal.":[145],"apical":[147,259],"RPE":[148,260,269,279],"surface":[149],"dedifferentiated":[150],"during":[151],"interval.":[154],"reattachment,":[159],"regrowth":[161],"rudimentary":[163],"ROSs":[164,176,199],"COSs":[166,178,201],"had.":[167],"occurred,":[168],"disc":[171,232,242],"stacking":[172],"clearly":[174],"abnormal.":[175],"both":[179],"showed":[180],"increase":[182],"in":[183,222,287,376,413],"length":[184],"tendency":[187],"return":[189],"their":[191,206,393,399],"normal":[192,207,400],"configurations":[193],"increasing":[195],"time":[196],"regained":[202],"approximately":[203],"40%":[204],"lengths":[208],"2-week":[211],"reattachment":[212],"period;":[213],"however,":[214],"persistent":[215],"segment":[217,300],"abnormalities":[218],"frequently":[220],"found":[221],"otherwise":[223],"well":[224],"regenerated":[225],"areas.":[226],"Autoradiographic":[227],"results":[228],"confirmed":[229],"that":[230],"new":[231],"membranes":[233,243],"synthesized":[235,240],"subsequent":[236],"Newly":[239],"uniformly":[245],"labeled":[246],"using":[247],"antibodies":[248],"bovine":[250],"opsin.":[251],"Regenerating":[252],"interdigitated":[255],"newly":[257],"formed":[258],"processes,":[261],"radiolabeled":[263],"phagosomes":[264],"identified":[266,283],"within":[267],"cytoplasm":[270],"week":[273],"Proliferation":[276],"cell":[280],"layer":[281],"locations":[286],"all":[288],"animals,":[289],"strongly":[292],"correlated":[293],"lack":[296],"underlying":[298,312],"regeneration.":[301],"Because":[302],"short":[305],"absence":[310],"pathology":[313],"trauma,":[315],"recovery":[317,327,419],"process":[318],"described":[319],"here":[320],"probably":[321],"represents":[322],"example":[324],"optimum":[326],"Invest":[331],"Ophthalmol":[332],"Vis":[333],"Sci":[334],"30:1708-1725,":[335],"1989":[336],"photoreceptor":[341],"cells":[342],"are":[343],"organelles":[344,360],"specialized":[345],"absorption":[348],"transduction":[350],"quanta":[353],"into":[354],"neuronal":[355],"activity.":[356],"Degeneration":[357],"these":[359],"is":[361,409],"one":[362,370],"most":[365,373],"prominent":[366],"morphological":[367],"changes,":[368],"significant":[374],"factors":[375],"loss":[378],"vision,":[380],"detachment.":[383],"Conversely,":[384],"capacity":[386],"rods":[388],"cones":[390],"regenerate":[392],"reestablish":[398],"anatomical":[401],"relationship":[402],"important":[411],"factor":[412],"denning":[414],"limits":[416],"visual":[418]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}