{"id":"https://openalex.org/W2189587734","doi":"https://doi.org/10.4172/1948-5956.1000161","title":"Cerastes cerastes and Vipera lebetina Snake Venoms Apoptotic \u2013 Stimulating Activity to Human Breast Cancer Cells and Related Gene Modulation","display_name":"Cerastes cerastes and Vipera lebetina Snake Venoms Apoptotic \u2013 Stimulating Activity to Human Breast Cancer Cells and Related Gene Modulation","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2189587734","doi":"https://doi.org/10.4172/1948-5956.1000161","mag":"2189587734"},"language":"en","primary_location":{"id":"doi:10.4172/1948-5956.1000161","doi":"https://doi.org/10.4172/1948-5956.1000161","is_oa":true,"landing_page_url":"https://doi.org/10.4172/1948-5956.1000161","pdf_url":"https://doi.org/10.4172/1948-5956.1000161","source":{"id":"https://openalex.org/S88812196","display_name":"Journal of Cancer Science & Therapy","issn_l":"1948-5956","issn":["1948-5956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Science & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.4172/1948-5956.1000161","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063025932","display_name":"Rania Ibrahim Shebl","orcid":"https://orcid.org/0000-0003-2877-6196","observed_orcids":["https://orcid.org/0000-0003-2877-6196"]},"institutions":[{"id":"https://openalex.org/I4210134127","display_name":"Vacsera (Egypt)","ror":"https://ror.org/03nh6bz87","country_code":"EG","type":"company","lineage":["https://openalex.org/I4210134127"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Shebl RI","raw_affiliation_strings":["Department of Virology, The Holding Company for Biological Products and Vaccines (VACSERA), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, The Holding Company for Biological Products and Vaccines (VACSERA), Cairo, Egypt","institution_ids":["https://openalex.org/I4210134127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063025932"],"corresponding_institution_ids":["https://openalex.org/I4210134127"],"apc_list":null,"apc_paid":null,"fwci":1.0792,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77449427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"04","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.9179999828338623},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression-modulation","display_name":"gene expression modulation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.871529757976532},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5922178030014038},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5517615079879761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5293408632278442},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5252059102058411},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5049970746040344},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.48961859941482544},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.483009934425354},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4813733398914337},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.44661635160446167},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.42779049277305603},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37021559476852417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34501412510871887},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3304188847541809},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15130510926246643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13676941394805908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08925902843475342}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4172/1948-5956.1000161","doi":"https://doi.org/10.4172/1948-5956.1000161","is_oa":true,"landing_page_url":"https://doi.org/10.4172/1948-5956.1000161","pdf_url":"https://doi.org/10.4172/1948-5956.1000161","source":{"id":"https://openalex.org/S88812196","display_name":"Journal of Cancer Science & Therapy","issn_l":"1948-5956","issn":["1948-5956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Science & Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4172/1948-5956.1000161","doi":"https://doi.org/10.4172/1948-5956.1000161","is_oa":true,"landing_page_url":"https://doi.org/10.4172/1948-5956.1000161","pdf_url":"https://doi.org/10.4172/1948-5956.1000161","source":{"id":"https://openalex.org/S88812196","display_name":"Journal of Cancer Science & Therapy","issn_l":"1948-5956","issn":["1948-5956"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Science & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2189587734.pdf","grobid_xml":"https://content.openalex.org/works/W2189587734.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1490399517","https://openalex.org/W1571446406","https://openalex.org/W1791554167","https://openalex.org/W1849819493","https://openalex.org/W1910962382","https://openalex.org/W1921145068","https://openalex.org/W1970046714","https://openalex.org/W1975891291","https://openalex.org/W1988086682","https://openalex.org/W1991192555","https://openalex.org/W1992855810","https://openalex.org/W2015879631","https://openalex.org/W2017614522","https://openalex.org/W2023700912","https://openalex.org/W2032946509","https://openalex.org/W2036155970","https://openalex.org/W2038762242","https://openalex.org/W2044496947","https://openalex.org/W2044907458","https://openalex.org/W2045468646","https://openalex.org/W2046294188","https://openalex.org/W2055516201","https://openalex.org/W2059763303","https://openalex.org/W2064591179","https://openalex.org/W2065955521","https://openalex.org/W2067976250","https://openalex.org/W2070811222","https://openalex.org/W2079463756","https://openalex.org/W2080156248","https://openalex.org/W2097786201","https://openalex.org/W2102382046","https://openalex.org/W2108966286","https://openalex.org/W2113089389","https://openalex.org/W2121276303","https://openalex.org/W2121959112","https://openalex.org/W2140679176","https://openalex.org/W2143546230","https://openalex.org/W2152315374","https://openalex.org/W2169597641","https://openalex.org/W2185417808","https://openalex.org/W2274550965","https://openalex.org/W4299736779","https://openalex.org/W4400020887"],"related_works":["https://openalex.org/W3007461112","https://openalex.org/W4322583519","https://openalex.org/W2560513572","https://openalex.org/W3009678878","https://openalex.org/W2140963203","https://openalex.org/W2005873892","https://openalex.org/W2023700912","https://openalex.org/W4390700962","https://openalex.org/W2054583793","https://openalex.org/W4210333182"],"abstract_inverted_index":{"Apoptosis":[0],"occurs":[1],"normally":[2],"during":[3],"development":[4,30],"and":[5,24,53,75,138,160],"aging":[6],"as":[7,154],"a":[8,73,158],"homeostatic":[9],"mechanism":[10],"to":[11,28,63,117],"maintain":[12],"cell":[13,22,25],"populations.Dysregulation":[14],"of":[15,31,35,109,132,141],"apoptosis":[16,65,126],"can":[17],"disrupt":[18],"the":[19,29,33,48,107,120],"equilibrium":[20],"between":[21],"growth":[23],"death":[26],"leading":[27],"cancer.Thus,":[32],"investigation":[34],"new":[36],"biological":[37],"apoptotic":[38,85,110,155],"activators":[39],"could":[40,152],"play":[41],"an":[42,104],"important":[43],"role":[44],"in":[45,66,90,106,145],"cancer":[46,67,82,165],"therapy.In":[47],"present":[49],"study,":[50],"Cerastes":[51],"cerastes":[52],"Vipera":[54],"lebetina":[55],"snake":[56],"venoms":[57,71,124,151],"were":[58,88,127],"evaluated":[59],"for":[60,164],"their":[61],"ability":[62],"activate":[64],"cells":[68,93,111],"where":[69],"test":[70,123],"exhibited":[72],"concentration":[74],"time":[76],"dependent":[77],"cytotoxic":[78],"effect":[79],"on":[80],"breast":[81],"(MCF-7)":[83],"cells.Typical":[84],"morphological":[86],"features":[87],"demonstrated":[89],"venom":[91,118],"treated":[92],"detected":[94],"via":[95],"transmission":[96],"electron":[97],"microscope.In":[98],"addition,":[99],"flow":[100],"cytometric":[101],"analysis":[102],"showed":[103],"increase":[105],"percentage":[108],"post":[112],"24":[113],"h":[114],"treatment":[115],"relative":[116],"concentrations.At":[119],"molecular":[121],"level,":[122],"induced":[125],"mediated":[128],"by":[129],"up":[130],"regulation":[131,140],"pro-apoptotic":[133],"genes":[134],"(p53":[135],"&":[136],"Bax)":[137],"down":[139],"anti-apoptotic":[142],"gene":[143],"(Bcl-2)":[144],"MCF-7":[146],"cells,":[147],"indicating":[148],"that":[149],"these":[150],"serve":[153],"stimulators,":[156],"presenting":[157],"novel":[159],"potential":[161],"therapeutic":[162],"strategy":[163],"treatment.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}