{"id":"https://openalex.org/W2189579756","doi":null,"title":"Protein kinases in high grade glioma: Towards therapeutic concoctions","display_name":"Protein kinases in high grade glioma: Towards therapeutic concoctions","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2189579756","mag":"2189579756"},"language":"en","primary_location":{"id":"mag:2189579756","doi":null,"is_oa":false,"landing_page_url":"http://biomedres.info/yahoo_site_admin/assets/docs/39-47-Roland_corrRMH.28223733.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058977071","display_name":"Roland M. Huber","orcid":"https://orcid.org/0000-0002-8346-3654","observed_orcids":["https://orcid.org/0000-0002-8346-3654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland M. Huber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8346-3654","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014940156","display_name":"Adrian Merlo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian Merlo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110213447","display_name":"Brian A. Hemmings","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian A. Hemmings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064979070","display_name":"Friedrich Miescher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Friedrich Miescher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.9800000190734863},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glioma-angiogenesis","display_name":"glioma angiogenesis","score":0.722000002861023},{"id":"https://openalex.org/keywords/gliomagenesis","display_name":"gliomagenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7515117526054382},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7348676919937134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5425887107849121},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4845272898674011},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48125454783439636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.432233065366745},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33037859201431274},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28897905349731445}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2189579756","doi":null,"is_oa":false,"landing_page_url":"http://biomedres.info/yahoo_site_admin/assets/docs/39-47-Roland_corrRMH.28223733.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W197014098","https://openalex.org/W1522230447","https://openalex.org/W1545570549","https://openalex.org/W1555073840","https://openalex.org/W1575973365","https://openalex.org/W1588880146","https://openalex.org/W1905312004","https://openalex.org/W1917703525","https://openalex.org/W1929023701","https://openalex.org/W1966222774","https://openalex.org/W1968054914","https://openalex.org/W1969656908","https://openalex.org/W1975678399","https://openalex.org/W1978139448","https://openalex.org/W1986683027","https://openalex.org/W1987382882","https://openalex.org/W1990937647","https://openalex.org/W1994651714","https://openalex.org/W1998007585","https://openalex.org/W1998819602","https://openalex.org/W1999778470","https://openalex.org/W2002727873","https://openalex.org/W2003736915","https://openalex.org/W2011810742","https://openalex.org/W2011845911","https://openalex.org/W2015344488","https://openalex.org/W2019746097","https://openalex.org/W2021705436","https://openalex.org/W2025183726","https://openalex.org/W2025370055","https://openalex.org/W2031499319","https://openalex.org/W2034144674","https://openalex.org/W2034207796","https://openalex.org/W2036164831","https://openalex.org/W2036418044","https://openalex.org/W2039584708","https://openalex.org/W2041098455","https://openalex.org/W2044351212","https://openalex.org/W2054779757","https://openalex.org/W2055475004","https://openalex.org/W2058332573","https://openalex.org/W2063734813","https://openalex.org/W2064325114","https://openalex.org/W2064548992","https://openalex.org/W2068666805","https://openalex.org/W2076457965","https://openalex.org/W2082853003","https://openalex.org/W2093062161","https://openalex.org/W2093783077","https://openalex.org/W2095027624","https://openalex.org/W2096481282","https://openalex.org/W2097876071","https://openalex.org/W2098588666","https://openalex.org/W2100390505","https://openalex.org/W2101781016","https://openalex.org/W2102056525","https://openalex.org/W2103687538","https://openalex.org/W2105150451","https://openalex.org/W2105602306","https://openalex.org/W2114098415","https://openalex.org/W2114998237","https://openalex.org/W2115862526","https://openalex.org/W2118587431","https://openalex.org/W2119836524","https://openalex.org/W2122452009","https://openalex.org/W2123808042","https://openalex.org/W2126890008","https://openalex.org/W2127745545","https://openalex.org/W2129269004","https://openalex.org/W2129648100","https://openalex.org/W2130139391","https://openalex.org/W2130268014","https://openalex.org/W2130926378","https://openalex.org/W2131799762","https://openalex.org/W2135823227","https://openalex.org/W2138231208","https://openalex.org/W2140375000","https://openalex.org/W2147535764","https://openalex.org/W2152998293","https://openalex.org/W2155883999","https://openalex.org/W2156216950","https://openalex.org/W2157992516","https://openalex.org/W2159594827","https://openalex.org/W2159817656","https://openalex.org/W2161289668","https://openalex.org/W2161810908","https://openalex.org/W2170316270","https://openalex.org/W2400892281"],"related_works":["https://openalex.org/W2759368807","https://openalex.org/W2100390505","https://openalex.org/W4409480291","https://openalex.org/W2103757972","https://openalex.org/W1987382882","https://openalex.org/W2539131576","https://openalex.org/W1902487713","https://openalex.org/W3119505753","https://openalex.org/W2030518964","https://openalex.org/W2101781016"],"abstract_inverted_index":{"Kinases":[0],"relay":[1],"incoming":[2],"input":[3],"to":[4,12,89,105,123,131,212,237,310],"downstream":[5],"proteins":[6],"by":[7,160],"covalently":[8],"linking":[9],"phosphate":[10],"groups":[11],"their":[13],"targets.":[14],"This":[15],"phosphorylation":[16],"acts":[17],"as":[18,153,258,269],"a":[19,148,151,244],"biological":[20],"switch":[21],"regulating":[22,46],"the":[23,26,49,67,106,132,139,169,173,178,203,220,224,227,274,318],"function":[24],"of":[25,48,76,101,135,144,176,194,202,246,249],"target":[27],"molecules.":[28],"While":[29],"simple":[30],"in":[31,40,83,118,172,197,280,294,324],"its":[32],"g":[33],"eneral":[34],"design,":[35],"protein":[36],"kinase":[37,85,115,152],"signaling":[38,111],"functions":[39],"highly":[41,113],"complex":[42],"networks":[43,61],"and":[44,53,66,81,92,189,214,232,240,304],"cascades":[45],"some":[47],"most":[50,275],"essential":[51],"cellular":[52,251],"physiological":[54],"functions.":[55],"Subtle":[56],"changes":[57],"i":[58],"n":[59],"these":[60,145,183],"can":[62,290],"have":[63,120,185,216,311],"devastating":[64,217],"consequences":[65,218],"deadliest":[68],"among":[69,108],"all":[70,230,296],"is":[71,138,157,226,273,286],"cancer.":[72],"Primary":[73],"brain":[74,225,247,278],"tumors":[75,248],"glial":[77,250],"origin":[78,252],"show":[79],"mutations":[80],"alterations":[82],"several":[84,161],"ca":[86],"scades":[87],"leading":[88],"aberrant":[90],"growth":[91],"tissue":[93],"invasion.":[94],"Molecular":[95],"profiling":[96],"has":[97],"identified":[98],"key":[99,154],"pathways":[100],"gliomagenesis":[102],"but":[103],"due":[104],"redundancy":[107],"glioma":[109,136,198],"promoting":[110],"pathways,":[112],"specific":[114],"inhibitors":[116],"used":[117],"mono-therapies":[119],"not":[121,309],"led":[122],"clear":[124],"c":[125],"linical":[126],"benefits":[127],"so":[128,187],"far.":[129],"Adding":[130],"dismal":[133],"prognosis":[134,283],"patients":[137],"strong":[140],"angi":[141],"ogenic":[142],"potential":[143],"tumors;":[146],"again,":[147],"process":[149],"with":[150,253,289],"regulator":[155],"which":[156,306],"tar":[158],"geted":[159],"molecular":[162],"strategies.":[163],"In":[164],"this":[165],"review,":[166],"we":[167],"summarize":[168],"kinases":[170,184,196],"involved":[171],"main":[174],"features":[175],"glioblastoma,":[177],"effect":[179],"targeted":[180],"therapies":[181],"against":[182],"shown":[186],"far":[188],"critically":[190],"discuss":[191],"future":[192],"options":[193],"targeting":[195],"therapy.":[199],"Review":[200],"Diseases":[201],"central":[204],"nervous":[205],"system":[206],"(CNS)":[207],"are":[208],"pa":[209],"rticularly":[210],"difficult":[211],"treat":[213],"often":[215],"for":[219,229,284],"affected":[221],"patients,":[222],"since":[223],"hub":[228],"afferent":[231],"efferent":[233],"messages,":[234],"giving":[235],"rise":[236],"consciousness,":[238],"cognition":[239],"personality.":[241],"Malignant":[242],"gliomas,":[243],"class":[245],"WHO":[254,270],"grades":[255],"II-IV,":[256],"manifest":[257],"astrocytoma,":[259],"oligodendroglioma,":[260],"mixed":[261],"oligo-astrocytoma":[262],"or":[263],"glioblastoma":[264],"multiforme":[265],"(GBM).":[266],"GBM,":[267],"graded":[268],"IV":[271],"tumor,":[272],"common":[276],"primary":[277],"tumor":[279],"adults.":[281],"The":[282],"GBM":[285],"particularly":[287],"poor":[288],"cer":[291],"related":[292],"death":[293],"almost":[295],"cases.":[297],"Treatment":[298],"includ":[299],"es":[300],"surgical":[301],"resection,":[302],"radio-":[303],"chemo-therapy":[305],"app":[307],"ears":[308],"substantially":[312],"improved":[313],"mean":[314],"survival":[315],"ov":[316],"er":[317],"past":[319],"decades":[320],"reaching":[321],"14-17":[322],"months":[323],"selected":[325],"stud":[326],"y":[327],"populations":[328],"[1,2].(.)":[329]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}