{"id":"https://openalex.org/W2189524606","doi":null,"title":"DETECTION AND QUANTIFICATION OF MINORITY KRAS SUBCLONES IN TUMORS USING DROPLET-BASED MICROFLUIDICS: CLINICAL IMPLICATION","display_name":"DETECTION AND QUANTIFICATION OF MINORITY KRAS SUBCLONES IN TUMORS USING DROPLET-BASED MICROFLUIDICS: CLINICAL IMPLICATION","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2189524606","mag":"2189524606"},"language":"en","primary_location":{"id":"mag:2189524606","doi":null,"is_oa":false,"landing_page_url":"https://www.rsc.org/images/loc/2013/PDFs/Papers/604_0569.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022272727","display_name":"Deniz Pekin","orcid":"https://orcid.org/0000-0001-6775-9685","observed_orcids":["https://orcid.org/0000-0001-6775-9685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deniz Pekin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6775-9685","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103351528","display_name":"Corinne Normand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Normand","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4507-4161","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060204545","display_name":"Steve K. Kotsopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve K. Kotsopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056887965","display_name":"X. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001647838","display_name":"L\u00e9onor Benha\u00efm","orcid":"https://orcid.org/0000-0003-3948-4156","observed_orcids":["https://orcid.org/0000-0003-3948-4156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L\u00e9onor Benha\u00efm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3948-4156","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077000250","display_name":"Olivier Bouch\u00e9","orcid":"https://orcid.org/0000-0002-8284-3743","observed_orcids":["https://orcid.org/0000-0002-8284-3743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Bouch\u00e9","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8284-3743","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084815041","display_name":"Thierry Lecomte","orcid":"https://orcid.org/0000-0001-5093-0212","observed_orcids":["https://orcid.org/0000-0001-5093-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thierry Lecompte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064362753","display_name":"Delphine Le Corre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delphine Le Corre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110561477","display_name":"Th\u00e9vy Hor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Hor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074239278","display_name":"Zakaria El Harrak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zakaria El Harrak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003566457","display_name":"Philippe Nizard","orcid":"https://orcid.org/0000-0002-7880-7029","observed_orcids":["https://orcid.org/0000-0002-7880-7029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philippe Nizard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7880-7029","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045067310","display_name":"Darren R. Link","orcid":"https://orcid.org/0000-0002-3203-5705","observed_orcids":["https://orcid.org/0000-0002-3203-5705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darren R. Link","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3203-5705","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089818289","display_name":"Pierre Laurent\u2010Puig","orcid":"https://orcid.org/0000-0001-8475-5459","observed_orcids":["https://orcid.org/0000-0001-8475-5459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Laurent\u2013Puig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8475-5459","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040195958","display_name":"Val\u00e9rie Taly","orcid":"https://orcid.org/0000-0002-3116-8602","observed_orcids":["https://orcid.org/0000-0002-3116-8602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Taly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3116-8602","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18802933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.423799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.423799991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.4050000011920929,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8859999775886536},{"id":"https://openalex.org/keywords/tumor-subclones","display_name":"tumor subclones","score":0.7409999966621399},{"id":"https://openalex.org/keywords/droplet-digital-pcr","display_name":"droplet digital PCR","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mutation-detection","display_name":"mutation detection","score":0.38199999928474426},{"id":"https://openalex.org/keywords/mutation-quantification","display_name":"mutation quantification","score":0.6259999871253967},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8893880844116211},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7224878072738647},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.707084596157074},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.6767275333404541},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.6477512121200562},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.5815325975418091},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4958373010158539},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4659949541091919},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.42274969816207886},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3913750648498535},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38582518696784973},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3835664391517639},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3701736032962799},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35125696659088135},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3203933835029602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30367493629455566},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21552500128746033},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18871352076530457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1763400137424469},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12367582321166992},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10950490832328796}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2189524606","doi":null,"is_oa":false,"landing_page_url":"https://www.rsc.org/images/loc/2013/PDFs/Papers/604_0569.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2026125236","https://openalex.org/W2083086303","https://openalex.org/W2106787323","https://openalex.org/W2120490763","https://openalex.org/W2129255527","https://openalex.org/W2135672185","https://openalex.org/W2145927385","https://openalex.org/W2189394034"],"related_works":["https://openalex.org/W2031413186","https://openalex.org/W2138713106","https://openalex.org/W6960229316","https://openalex.org/W4399318730","https://openalex.org/W7097893869","https://openalex.org/W2564292626","https://openalex.org/W3025643975","https://openalex.org/W2413380883","https://openalex.org/W2909200349","https://openalex.org/W2093263354"],"abstract_inverted_index":{"We":[0],"used":[1],"a":[2,9,16],"multiplex":[3],"droplet-based":[4],"digital":[5],"PCR":[6],"method":[7],"in":[8,32],"retrospective":[10],"study":[11],"including":[12],"181":[13],"patients":[14],"with":[15],"metastatic":[17],"colorectal":[18],"cancer":[19],"(mCRC)":[20],"for":[21],"the":[22],"quantitative":[23],"and":[24,29],"sensitive":[25],"detection":[26],"of":[27],"KRAS":[28],"BRAF":[30],"mutations":[31],"DNA":[33],"extracted":[34],"from":[35],"tumors.":[36]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2016-06-24T00:00:00"}
