{"id":"https://openalex.org/W2189458034","doi":null,"title":"Agomelatine: The Novel Antidepressant","display_name":"Agomelatine: The Novel Antidepressant","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2189458034","mag":"2189458034"},"language":"en","primary_location":{"id":"mag:2189458034","doi":null,"is_oa":false,"landing_page_url":"https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001845512","pdf_url":null,"source":{"id":"https://openalex.org/S4306496401","display_name":"\ub300\ud55c\uc815\uc2e0\uc57d\ubb3c\ud559\ud68c\uc9c0","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Psychopharmacology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069788480","display_name":"Woo Young Sup","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woo Young Sup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035507343","display_name":"\uc655\ud76c\ub839","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\uc655\ud76c\ub839","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020978103","display_name":"Won\u2010Myong Bahk","orcid":"https://orcid.org/0000-0002-0156-2510","observed_orcids":["https://orcid.org/0000-0002-0156-2510"]},"institutions":[{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won\u2010Myong Bahk","raw_affiliation_strings":["Catholic University of Korea"],"raw_orcid":"https://orcid.org/0000-0002-0156-2510","affiliations":[{"raw_affiliation_string":"Catholic University of Korea","institution_ids":["https://openalex.org/I87111246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4276,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.86937685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agomelatine","display_name":"agomelatine","score":1.0},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.902999997138977},{"id":"https://openalex.org/keywords/5-ht2c-receptor-antagonist","display_name":"5-HT2C receptor antagonist","score":0.8479999899864197},{"id":"https://openalex.org/keywords/melatonin-receptor-agonists","display_name":"melatonin receptor agonists","score":0.9959999918937683},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.7720000147819519},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antidepressant-safety","display_name":"antidepressant safety","score":0.9139999747276306},{"id":"https://openalex.org/keywords/sexual-dysfunction","display_name":"sexual dysfunction","score":0.8830000162124634},{"id":"https://openalex.org/keywords/serotonin-syndrome","display_name":"serotonin syndrome","score":0.9679999947547913},{"id":"https://openalex.org/keywords/discontinuation-syndrome","display_name":"discontinuation syndrome","score":0.8970000147819519},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2780798758","wikidata":"https://www.wikidata.org/wiki/Q395229","display_name":"Agomelatine","level":4,"score":0.9793604612350464},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.722900390625},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.6514931917190552},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.6318321228027344},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.589905321598053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5371063351631165},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.460647851228714},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.43277472257614136},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4045623540878296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38770732283592224},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36261096596717834},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.333370566368103},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3054198920726776},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.11838927865028381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11018341779708862},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2189458034","doi":null,"is_oa":false,"landing_page_url":"https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001845512","pdf_url":null,"source":{"id":"https://openalex.org/S4306496401","display_name":"\ub300\ud55c\uc815\uc2e0\uc57d\ubb3c\ud559\ud68c\uc9c0","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Korean Journal of Psychopharmacology","raw_type":null},{"id":"mag:2223415163","doi":null,"is_oa":false,"landing_page_url":"http://dspace.kci.go.kr/handle/kci/1439443","pdf_url":null,"source":{"id":"https://openalex.org/S4306496401","display_name":"\ub300\ud55c\uc815\uc2e0\uc57d\ubb3c\ud559\ud68c\uc9c0","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\ub300\ud55c\uc815\uc2e0\uc57d\ubb3c\ud559\ud68c\uc9c0","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W61992062","https://openalex.org/W79115161","https://openalex.org/W199968895","https://openalex.org/W1541441850","https://openalex.org/W1761390008","https://openalex.org/W1764422414","https://openalex.org/W1821913765","https://openalex.org/W1932790829","https://openalex.org/W1964666670","https://openalex.org/W1965355495","https://openalex.org/W1967246300","https://openalex.org/W1968644016","https://openalex.org/W1976784386","https://openalex.org/W1977708183","https://openalex.org/W1982665253","https://openalex.org/W1988123141","https://openalex.org/W1990454576","https://openalex.org/W1990644324","https://openalex.org/W1992439764","https://openalex.org/W1998894503","https://openalex.org/W2000943191","https://openalex.org/W2001573994","https://openalex.org/W2003139853","https://openalex.org/W2005935080","https://openalex.org/W2006272001","https://openalex.org/W2008923253","https://openalex.org/W2011253374","https://openalex.org/W2014028088","https://openalex.org/W2021091334","https://openalex.org/W2021772552","https://openalex.org/W2021969484","https://openalex.org/W2022032351","https://openalex.org/W2029586222","https://openalex.org/W2031809759","https://openalex.org/W2037831322","https://openalex.org/W2040320169","https://openalex.org/W2041439880","https://openalex.org/W2045543396","https://openalex.org/W2045614420","https://openalex.org/W2046271238","https://openalex.org/W2058331036","https://openalex.org/W2059735897","https://openalex.org/W2072188825","https://openalex.org/W2072219714","https://openalex.org/W2072472304","https://openalex.org/W2073749725","https://openalex.org/W2074893013","https://openalex.org/W2084088430","https://openalex.org/W2086546977","https://openalex.org/W2089180488","https://openalex.org/W2089183270","https://openalex.org/W2091667890","https://openalex.org/W2099080686","https://openalex.org/W2103044052","https://openalex.org/W2103431948","https://openalex.org/W2104247936","https://openalex.org/W2107278158","https://openalex.org/W2111591257","https://openalex.org/W2115908598","https://openalex.org/W2116424257","https://openalex.org/W2120729007","https://openalex.org/W2126079670","https://openalex.org/W2130100911","https://openalex.org/W2132270063","https://openalex.org/W2141979672","https://openalex.org/W2147406359","https://openalex.org/W2148665968","https://openalex.org/W2151484167","https://openalex.org/W2152670033","https://openalex.org/W2152748130","https://openalex.org/W2156308703","https://openalex.org/W2161185297","https://openalex.org/W2161731199","https://openalex.org/W2809731100"],"related_works":["https://openalex.org/W2084088430","https://openalex.org/W1036170216","https://openalex.org/W2158816287","https://openalex.org/W2048393380","https://openalex.org/W2107278158","https://openalex.org/W2121041697","https://openalex.org/W2357778525","https://openalex.org/W1580029690","https://openalex.org/W2114843189","https://openalex.org/W7008526484"],"abstract_inverted_index":{"Major":[0],"depression":[1,68],"is":[2,80],"a":[3,85,181],"common":[4],"mental":[5],"illness,":[6],"associated":[7,142],"with":[8,84,143],"high":[9,26],"morbidity":[10],"and":[11,38,96,130,146,171],"mortality.":[12],"Antidepressants":[13],"have":[14,102,115],"been":[15,46,77],"the":[16,64,71,169,187],"first-line":[17],"therapies":[18],"due":[19],"to":[20,32,49,123,139],"their":[21,42],"confirmed":[22],"efficacy,":[23,43],"however,":[24],"considering":[25],"rate":[27],"of":[28,41,66,88,120,135,173,189],"poor":[29],"treatment":[30,184,188],"response":[31],"these":[33],"therapies,":[34],"distressing":[35],"side":[36],"effects,":[37],"delayed":[39],"onset":[40],"there":[44],"has":[45,69,76,148],"much":[47],"effort":[48],"find":[50],"alternative":[51,185],"treatments":[52],"for":[53,151],"major":[54,67,111],"depression.":[55,112,190],"Recently,":[56],"evidence":[57],"regarding":[58],"disturbed":[59],"circadian":[60],"rhythms":[61],"involved":[62],"in":[63,109,175,186],"pathophysiology":[65],"emerged,":[70],"interest":[72],"on":[73,168],"this":[74],"area":[75],"increasing.":[78],"Agomelatine":[79],"an":[81],"emerging":[82],"antidepressant,":[83],"unique":[86],"profile":[87,134],"selective":[89,161],"antagonist":[90],"at":[91],"serotonin":[92,152,162],"2C":[93],"(5-HT2C)":[94],"receptors":[95],"melatonin":[97],"receptor":[98],"agonist.":[99],"Previous":[100,113],"studies":[101],"shown":[103,116],"its":[104],"superior":[105],"efficacy":[106,119,170],"over":[107],"placebo":[108],"treating":[110,176],"trials":[114],"comparable":[117],"antidepressant":[118],"agomelatine":[121,174],"compared":[122],"other":[124],"standard":[125,158],"antidepressants":[126,159],"including":[127,160],"venlafaxine,":[128],"sertraline,":[129],"fluoxetine.":[131],"Regarding":[132],"safety":[133,172],"agomelatine,":[136],"it":[137,147,178],"seems":[138],"be":[140,180],"not":[141],"sexual":[144],"dysfunction":[145],"less":[149],"potential":[150],"syndrome":[153,156],"or":[154],"discontinuation":[155],"than":[157],"reuptake":[163],"inhibitors.":[164],"Considering":[165],"favorable":[166],"results":[167],"depression,":[177],"could":[179],"good,":[182],"safe":[183]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
