{"id":"https://openalex.org/W2189346095","doi":"https://doi.org/10.18632/oncoscience.189","title":"JAK-STAT in lymphoproliferative disorders","display_name":"JAK-STAT in lymphoproliferative disorders","publication_year":2015,"publication_date":"2015-08-11","ids":{"openalex":"https://openalex.org/W2189346095","doi":"https://doi.org/10.18632/oncoscience.189","mag":"2189346095","pmid":"https://pubmed.ncbi.nlm.nih.gov/26501073","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4606001"},"language":"en","primary_location":{"id":"doi:10.18632/oncoscience.189","doi":"https://doi.org/10.18632/oncoscience.189","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.189","pdf_url":"https://doi.org/10.18632/oncoscience.189","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncoscience.189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056128255","display_name":"Ra\u00fal Rabad\u00e1n","orcid":"https://orcid.org/0000-0001-7946-9255","observed_orcids":["https://orcid.org/0000-0001-7946-9255"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raul Rabadan","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","Giorgio Inghirami: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Giorgio Inghirami: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006640724","display_name":"Giorgio Inghirami","orcid":"https://orcid.org/0000-0001-5566-0864","observed_orcids":["https://orcid.org/0000-0001-5566-0864","https://orcid.org/0000-0002-5298-6516"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Giorgio Inghirami","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","Giorgio Inghirami: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Giorgio Inghirami: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006640724"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":0.1339,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.53967734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"2","issue":"9","first_page":"737","last_page":"738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lymphoproliferative-disorders","display_name":"lymphoproliferative disorders","score":0.9670000076293945},{"id":"https://openalex.org/keywords/signal-transducer-and-activator-of-transcription","display_name":"signal transducer and activator of transcription","score":0.9100000262260437},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/plasma-membrane-receptors","display_name":"plasma membrane receptors","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.8421066999435425},{"id":"https://openalex.org/C2776995267","wikidata":"https://www.wikidata.org/wiki/Q4165484","display_name":"Lymphoproliferative disorders","level":3,"score":0.7316673398017883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4593423306941986},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.44501906633377075},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42212027311325073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22666791081428528},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.20399713516235352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19252008199691772},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.1253667175769806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11496654152870178},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1101292073726654},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08657592535018921},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.05554500222206116}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.18632/oncoscience.189","doi":"https://doi.org/10.18632/oncoscience.189","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.189","pdf_url":"https://doi.org/10.18632/oncoscience.189","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3587020","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4606001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4606001","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4606001","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"Text"},{"id":"pmid:26501073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26501073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.7810","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.7810","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8e/5f/oncoscience-02-0737.PMC4606001.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.18632/oncoscience.189","doi":"https://doi.org/10.18632/oncoscience.189","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncoscience.189","pdf_url":"https://doi.org/10.18632/oncoscience.189","source":{"id":"https://openalex.org/S4210206977","display_name":"Oncoscience","issn_l":"2331-4737","issn":["2331-4737"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncoscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2189346095.pdf","grobid_xml":"https://content.openalex.org/works/W2189346095.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W259732519","https://openalex.org/W644234115","https://openalex.org/W1968235930","https://openalex.org/W1973454407","https://openalex.org/W2007739717","https://openalex.org/W2028544780","https://openalex.org/W2147915026","https://openalex.org/W2158312458","https://openalex.org/W2945792041"],"related_works":["https://openalex.org/W2240104803","https://openalex.org/W2150857908","https://openalex.org/W1975202136","https://openalex.org/W7096390869","https://openalex.org/W2072286261","https://openalex.org/W2112440733","https://openalex.org/W1980814049","https://openalex.org/W1981760747","https://openalex.org/W2471853362","https://openalex.org/W7209139522"],"abstract_inverted_index":{"In":[0],"the":[1,9,13,18,46,55,58],"early":[2],"1990\u2019s":[3],"several":[4],"groups":[5,65],"were":[6,31],"searching":[7],"for":[8],"molecular":[10],"basis":[11],"of":[12,20,26,51,60],"signal":[14,47],"transduction":[15],"triggered":[16],"by":[17,73],"engagement":[19],"plasma":[21],"membrane":[22],"receptors.":[23],"The":[24],"laboratories":[25],"Darnell,":[27],"Kerr":[28],"and":[29,49,63],"Stark":[30],"first":[32],"to":[33],"identify":[34],"proteins,":[35],"which":[36],"acted":[37],"as":[38,45],"intermediaries":[39],"in":[40],"interferon":[41],"(IFN)":[42],"signaling,":[43],"known":[44],"transducer":[48],"activator":[50],"transcription":[52],"(STAT).":[53],"At":[54],"same":[56],"time,":[57],"work":[59],"Pellegrini\u2019s,":[61],"Ihle\u2019s":[62],"Carter-Su\u2019s":[64],"demonstrated":[66],"that":[67],"non-receptor":[68],"tyrosine":[69],"kinases,":[70],"previously":[71],"described":[72]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}