{"id":"https://openalex.org/W2189302885","doi":null,"title":"Immune Signature of Malignant Pleural Mesothelioma as Assessed by Transcriptome Analysis.","display_name":"Immune Signature of Malignant Pleural Mesothelioma as Assessed by Transcriptome Analysis.","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2189302885","mag":"2189302885","pmid":"https://pubmed.ncbi.nlm.nih.gov/31394644"},"language":"en","primary_location":{"id":"pmid:31394644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31394644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genomics & proteomics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088770783","display_name":"Steve Mohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I85905123","display_name":"Institut National de Recherche et de S\u00e9curit\u00e9","ror":"https://ror.org/01dg85j68","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I85905123"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Mohr","raw_affiliation_strings":["Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre","Institut de Biologie Mol\u00e9culaire et Cellulaire du Centre National de la Recherche Scientifique, UPR 9002, Rue Ren\u00e9 Descartes, 67084 Strasbourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre","institution_ids":["https://openalex.org/I85905123"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire et Cellulaire du Centre National de la Recherche Scientifique, UPR 9002, Rue Ren\u00e9 Descartes, 67084 Strasbourg","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I4210158086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055867845","display_name":"A. Neuville","orcid":"https://orcid.org/0000-0001-7573-9369","observed_orcids":["https://orcid.org/0000-0001-7573-9369"]},"institutions":[{"id":"https://openalex.org/I4210157127","display_name":"H\u00f4pital d'Hautepierre","ror":"https://ror.org/04e1w6923","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145324","https://openalex.org/I4210157127"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Neuville","raw_affiliation_strings":["Service d'Anatomie Pathologique, CHU de Hautepierre, 67098 Strasbourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'Anatomie Pathologique, CHU de Hautepierre, 67098 Strasbourg","institution_ids":["https://openalex.org/I4210157127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110286775","display_name":"Marie Claire Bottin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85905123","display_name":"Institut National de Recherche et de S\u00e9curit\u00e9","ror":"https://ror.org/01dg85j68","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I85905123"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M C Bottin","raw_affiliation_strings":["Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre","institution_ids":["https://openalex.org/I85905123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110286776","display_name":"Jean Claude Micillino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85905123","display_name":"Institut National de Recherche et de S\u00e9curit\u00e9","ror":"https://ror.org/01dg85j68","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I85905123"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J C Micillino","raw_affiliation_strings":["Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de Recherche et de S\u00e9curit\u00e9, Avenue de Bourgogne, BP27, 54501 Vandoeuvre","institution_ids":["https://openalex.org/I85905123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108188820","display_name":"G\u00e9rard Keith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210128885","display_name":"Architecture et R\u00e9activit\u00e9 de l'arN","ror":"https://ror.org/03xmjtz19","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210128885","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G Keith","raw_affiliation_strings":["Institut de Biologie Mol\u00e9culaire et Cellulaire du Centre National de la Recherche Scientifique, UPR 9002, Rue Ren\u00e9 Descartes, 67084 Strasbourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire et Cellulaire du Centre National de la Recherche Scientifique, UPR 9002, Rue Ren\u00e9 Descartes, 67084 Strasbourg","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210128885","https://openalex.org/I4210158086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104354671","display_name":"Bertrand Henri Rihn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B H Rihn","raw_affiliation_strings":["INSERM U525, 30 Rue Lionnois, 54000 Nancy, France Bertrand.Rihn@pharma.uhp-nancy1.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U525, 30 Rue Lionnois, 54000 Nancy, France Bertrand.Rihn@pharma.uhp-nancy1.fr","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"3","first_page":"125","last_page":"135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-signature","display_name":"tumor immune signature","score":0.718999981880188},{"id":"https://openalex.org/keywords/immunoresistance","display_name":"immunoresistance","score":0.8190000057220459},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7590000033378601},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.6690000295639038},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/asbestos-exposure","display_name":"asbestos exposure","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cd74","display_name":"CD74","score":0.7390000224113464},{"id":"https://openalex.org/keywords/ptgs1","display_name":"PTGS1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/igfbp7","display_name":"IGFBP7","score":0.9779999852180481},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta3","display_name":"transforming growth factor-beta3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/apoptosis-related-genes","display_name":"apoptosis-related genes","score":0.6389999985694885},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mesothelial-cells","display_name":"mesothelial cells","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.7997767925262451},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7450646758079529},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5267374515533447},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5074664950370789},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.48485267162323},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45786479115486145},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.42842257022857666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4263139069080353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39900293946266174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3143433928489685},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28125929832458496},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21849021315574646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08369681239128113}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:31394644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31394644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genomics & proteomics","raw_type":"Journal Article"},{"id":"mag:2189302885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31394644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W117605483","https://openalex.org/W1517873373","https://openalex.org/W1521689717","https://openalex.org/W1538287621","https://openalex.org/W1970655712","https://openalex.org/W1972158338","https://openalex.org/W1973926629","https://openalex.org/W1979014817","https://openalex.org/W1979568379","https://openalex.org/W1982629607","https://openalex.org/W1984839989","https://openalex.org/W1995209988","https://openalex.org/W1998650748","https://openalex.org/W2012274543","https://openalex.org/W2017935376","https://openalex.org/W2023819269","https://openalex.org/W2030219698","https://openalex.org/W2038354618","https://openalex.org/W2048191430","https://openalex.org/W2048425382","https://openalex.org/W2051940153","https://openalex.org/W2059818201","https://openalex.org/W2062125067","https://openalex.org/W2064967819","https://openalex.org/W2072696221","https://openalex.org/W2074953560","https://openalex.org/W2077989877","https://openalex.org/W2094138463","https://openalex.org/W2097255042","https://openalex.org/W2102866915","https://openalex.org/W2106719462","https://openalex.org/W2110458134","https://openalex.org/W2119800239","https://openalex.org/W2129026847","https://openalex.org/W2139564953","https://openalex.org/W2145572948","https://openalex.org/W2155850103","https://openalex.org/W2162433324","https://openalex.org/W2167787789","https://openalex.org/W2223359185","https://openalex.org/W2295630215","https://openalex.org/W2342126175","https://openalex.org/W2424711241","https://openalex.org/W2470071600","https://openalex.org/W2475302063"],"related_works":["https://openalex.org/W3043470854","https://openalex.org/W2570728510","https://openalex.org/W3112147447","https://openalex.org/W3090862993","https://openalex.org/W2766967575","https://openalex.org/W2936948460","https://openalex.org/W4385245277","https://openalex.org/W4387571323","https://openalex.org/W2793103066","https://openalex.org/W4384341055"],"abstract_inverted_index":{"Malignant":[0],"pleural":[1],"mesothelioma":[2,40],"(MPM)":[3],"is":[4,245],"a":[5,29,75,84,102,219],"highly":[6],"malignant":[7,39],"tumor":[8,137,158],"arising":[9],"in":[10,32,209],"patients":[11],"previously":[12],"exposed":[13],"to":[14,41,47,56,97,120,241,247,253],"asbestos":[15],"fibers.":[16],"Its":[17],"increasing":[18],"incidence":[19],"and":[20,24,59,190,196,217,232],"its":[21,234],"social,":[22],"financial":[23],"human":[25],"impact":[26],"have":[27,206],"become":[28],"frequent":[30],"problem":[31],"many":[33],"industrialized":[34],"countries.":[35],"The":[36,179],"unresponsiveness":[37],"of":[38,62,67,71,92,112,169,212,215],"conventional":[42],"therapies":[43],"has":[44,53],"led":[45],"clinicians":[46],"develop":[48],"new":[49,220],"treatments.":[50],"As":[51],"immunotherapy":[52],"been":[54],"shown":[55,165],"offer":[57,218],"promising":[58],"targeted":[60],"treatment":[61],"MPM":[63,72,94,226,250],"patients,":[64],"the":[65,68,89,121,145,150,154,157,160,167,174,210,223,249],"knowledge":[66],"immunoresistance":[69,183],"level":[70],"may":[73,135,227],"be":[74],"valuable":[76],"tool":[77],"for":[78],"\"\u00e0":[79],"la":[80],"carte\"":[81],"therapy.":[82],"In":[83,124],"previous":[85],"work,":[86],"we":[87,127],"profiled":[88],"gene":[90],"expression":[91,132,168],"two":[93],"tissues":[95],"compared":[96],"healthy":[98],"mesothelial":[99],"cells":[100,152],"using":[101],"10K":[103],"cDNA":[104],"microarray.":[105],"Subsequent":[106],"clustering":[107],"analysis":[108],"identified":[109],"several":[110],"clusters":[111],"differentially-expressed":[113],"genes":[114,130,181],"among":[115],"those":[116],"that":[117,134],"are":[118,184],"functionally-related":[119],"immune":[122,146,194,230],"system.":[123],"this":[125],"report,":[126],"focus":[128],"on":[129],"with":[131,159],"changes":[133],"facilitate":[136],"escape":[138,162],"from":[139],"immune-mediated":[140],"rejection.":[141],"We":[142],"also":[143],"analyzed":[144],"reaction":[147],"by":[148,166,192,201],"staining":[149],"immunocompetent":[151],"surrounding":[153],"tumor.":[155],"Interestingly,":[156],"strongest":[161,175],"response,":[163],"as":[164],"numerous":[170],"immunoresistance-associated":[171],"genes,":[172],"displayed":[173],"T":[176],"cell":[177],"infiltrate.":[178],"main":[180],"conferring":[182],"CD74,":[185],"HLADOA,":[186],"HLADMB,":[187],"PTGS1,":[188],"IGFBP7":[189],"TGFB3,":[191],"favoring":[193],"tolerance,":[195],"CFLAR,":[197],"DFFA,":[198],"TNFRSF6,":[199],"BNIP3L":[200],"impairing":[202],"apoptosis.":[203],"These":[204],"observations":[205],"fundamental":[207],"consequences":[208],"understanding":[211],"immunological":[213],"properties":[214],"MPM,":[216],"insight":[221],"into":[222],"mechanisms":[224],"whereby":[225],"circumvent":[228],"host-mediated":[229],"activities":[231],"promotes":[233],"own":[235],"development.":[236],"For":[237],"an":[238],"immunomodulation":[239],"strategy":[240],"cure":[242],"mesothelioma,":[243],"it":[244],"crucial":[246],"characterize":[248],"\"immune":[251],"signature\"":[252],"design":[254],"adapted":[255],"immunotherapies.":[256]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}