{"id":"https://openalex.org/W2189299873","doi":null,"title":"PHARMACODYNAMIC INTERACTION OF GARLIC WITH CAPTOPRIL IN ISCHEMIA-REPERFUSION INDUCED MYOCARDIAL DAMAGE IN RATS","display_name":"PHARMACODYNAMIC INTERACTION OF GARLIC WITH CAPTOPRIL IN ISCHEMIA-REPERFUSION INDUCED MYOCARDIAL DAMAGE IN RATS","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2189299873","mag":"2189299873"},"language":"en","primary_location":{"id":"mag:2189299873","doi":null,"is_oa":false,"landing_page_url":"https://pharmacologyonline.silae.it/files/archives/2008/vol2/87_Asdaq.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113314020","display_name":"Syed Mohammed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Mohammed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028700323","display_name":"Syed Mohammed Basheeruddin Asdaq","orcid":"https://orcid.org/0000-0003-1533-9667","observed_orcids":["https://orcid.org/0000-0003-1533-9667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Mohammed Basheeruddin Asdaq","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1533-9667","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110268147","display_name":"Mohammed Naseeruddin Inamdar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Naseeruddin Inamdar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7066,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77786687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/garlic","display_name":"garlic","score":0.6970000267028809},{"id":"https://openalex.org/keywords/captopril","display_name":"captopril","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6389999985694885},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9369999766349792},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.996999979019165},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.781000018119812},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":1.0},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7649999856948853},{"id":"https://openalex.org/keywords/langendorff-preparation","display_name":"isolated perfused heart","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.8843224048614502},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.7058923244476318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6022665500640869},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5596489310264587},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.5341559648513794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4948558211326599},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47105881571769714},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.4556659758090973},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4534105062484741},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4515116810798645},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.4393465518951416},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4330793023109436},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.4231809973716736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4104463458061218},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3464072048664093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29252660274505615},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.18663862347602844},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.13702455163002014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13273131847381592}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2189299873","doi":null,"is_oa":false,"landing_page_url":"https://pharmacologyonline.silae.it/files/archives/2008/vol2/87_Asdaq.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W49614849","https://openalex.org/W54604546","https://openalex.org/W107445082","https://openalex.org/W1581440172","https://openalex.org/W1803128538","https://openalex.org/W1904312815","https://openalex.org/W1965951694","https://openalex.org/W1985143568","https://openalex.org/W1991796446","https://openalex.org/W2001901270","https://openalex.org/W2004797845","https://openalex.org/W2009942091","https://openalex.org/W2025081357","https://openalex.org/W2031085448","https://openalex.org/W2049256916","https://openalex.org/W2058164136","https://openalex.org/W2059916134","https://openalex.org/W2066874708","https://openalex.org/W2067667511","https://openalex.org/W2070394262","https://openalex.org/W2083501616","https://openalex.org/W2094857442","https://openalex.org/W2104429032","https://openalex.org/W2134444274","https://openalex.org/W2143159590","https://openalex.org/W2147041834","https://openalex.org/W2150351630","https://openalex.org/W2188154618","https://openalex.org/W2409509754","https://openalex.org/W2414636159","https://openalex.org/W2467624077"],"related_works":["https://openalex.org/W2132638769","https://openalex.org/W3026552313","https://openalex.org/W179369507","https://openalex.org/W7220582895","https://openalex.org/W2581611259","https://openalex.org/W3154193770","https://openalex.org/W84926198","https://openalex.org/W2418943023","https://openalex.org/W1553066546","https://openalex.org/W2166803046"],"abstract_inverted_index":{"Summary":[0],"It":[1],"is":[2,35],"known":[3],"that":[4],"various":[5],"preparations":[6],"of":[7,53,62,85,131,154,218,225],"garlic":[8,40],"and":[9,24,43,46,92,104,110,125,150,158,180,185,197,232],"ACE":[10],"inhibitor":[11],"such":[12,228],"as":[13,173,229],"captopril":[14],"(CAP)":[15],"have":[16],"beneficial":[17],"effects":[18],"on":[19,66,106],"the":[20,51,54,60,129,191],"left":[21],"ventricular":[22],"function":[23],"cardiovascular":[25],"events":[26],"after":[27,47],"myocardial":[28],"infarction":[29],"(MI)":[30],"when":[31,208,243],"used":[32],"individually.":[33],"There":[34],"no":[36,116],"reported":[37],"interaction":[38,61],"between":[39],"homogenate":[41,141],"(GH)":[42],"CAP":[44,65,157,219],"during":[45,123,206],"acute":[48],"MI.":[49],"Thus":[50],"purpose":[52],"present":[55],"study":[56],"was":[57,135],"to":[58,112,168,210,239],"explore":[59],"GH":[63,80],"with":[64,79,156,248],"ischemia-reperfusion":[67],"injury":[68],"(IRI)":[69],"in":[70,163,178,183,188,194,203,214,223,234,257],"isolated":[71],"rat":[72],"heart":[73,134,139,198],"preparation.":[74],"Albino":[75],"rats":[76],"were":[77,102,120,146,200,253],"treated":[78,204],"at":[81],"three":[82],"different":[83],"doses":[84],"125":[86],"mg/kg,":[87],"(GH-125),":[88],"250":[89],"mg/kg":[90,94],"(GH-250)":[91],"500":[93],"(GH-500)":[95],"for":[96],"30":[97],"days":[98],"orally.":[99],"The":[100],"hearts":[101],"excised":[103],"mounted":[105],"modified":[107],"Langendorff":[108],"setup":[109],"subjected":[111],"15":[113],"min":[114],"global":[115],"flow":[117],"ischemia.":[118],"Perfusates":[119],"collected":[121],"both":[122],"pre":[124],"postischemic":[126],"period.":[127],"At":[128],"end":[130],"reperfusion,":[132],"ischemic":[133],"either":[136],"made":[137],"into":[138],"tissue":[140],"(HTH)":[142],"or":[143,162,216,246],"histological":[144],"slides":[145],"prepared":[147],"using":[148],"hematoxylin":[149],"eosin":[151],"stains.":[152],"Pretreatment":[153],"animals":[155],"GH-250":[159,213],"(either":[160],"alone":[161,245],"combination)":[164],"provided":[165],"significant":[166,176,221],"protection":[167],"myocardium":[169],"from":[170],"IRI":[171],"damage":[172],"indicated":[174],"by":[175,255],"decrease":[177],"LDH":[179],"CK-MB":[181],"activities":[182,224],"perfusate":[184],"vice":[186],"versa":[187],"HTH.":[189,235],"Similarly,":[190],"recovery":[192],"(%)":[193],"developed":[195],"tension":[196],"rate":[199],"significantly":[201],"more":[202],"groups":[205],"post-ischemia":[207],"compared":[209],"control.":[211],"Moreover,":[212],"presence":[215],"absence":[217],"showed":[220],"increase":[222],"antioxidant":[226],"enzymes":[227],"superoxide":[230],"dismutase":[231],"catalase":[233],"However,":[236],"GH-500":[237],"failed":[238],"show":[240],"cardioprotective":[241],"effect":[242],"given":[244],"along":[247],"CAP.":[249],"These":[250],"biochemical":[251],"findings":[252],"supported":[254],"changes":[256],"histopathological":[258],"studies.":[259]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
