{"id":"https://openalex.org/W2189233644","doi":null,"title":"Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.","display_name":"Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2189233644","mag":"2189233644","pmid":"https://pubmed.ncbi.nlm.nih.gov/14617781"},"language":"en","primary_location":{"id":"pmid:14617781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14617781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100390416","display_name":"Xueyan Wang","orcid":"https://orcid.org/0000-0002-6331-9807","observed_orcids":["https://orcid.org/0000-0002-6331-9807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueyan Wang","raw_affiliation_strings":["SUGEN, Inc., South San Francisco, CA, USA. xwang720@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUGEN, Inc., South San Francisco, CA, USA. xwang720@yahoo.com","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Phuong Le","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phuong Le","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103519232","display_name":"Congxin Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Congxin Liang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Julie Chan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Chan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038834755","display_name":"David Kiewlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Kiewlich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113466047","display_name":"Todd M. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dave Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dave Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058555021","display_name":"Li Sun","orcid":"https://orcid.org/0000-0002-0849-1081","observed_orcids":["https://orcid.org/0000-0002-0849-1081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088339230","display_name":"Audie G. Rice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audie Rice","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034968976","display_name":"Stefan Vasile","orcid":"https://orcid.org/0000-0002-2679-7156","observed_orcids":["https://orcid.org/0000-0002-2679-7156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Vasile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109915459","display_name":"Robert A. Blake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A Blake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002221685","display_name":"Anthony R. Howlett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony R Howlett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112283072","display_name":"Neela Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neela Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069477348","display_name":"Gerald McMahon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald McMahon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073316865","display_name":"Kenneth E. Lipson","orcid":"https://orcid.org/0000-0001-8847-6051","observed_orcids":["https://orcid.org/0000-0001-8847-6051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth E Lipson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6171,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.90203278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2","issue":"11","first_page":"1085","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.09799999743700027,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/met-receptor-tyrosine-kinase","display_name":"MET receptor tyrosine kinase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/small-molecule-kinase-inhibitors","display_name":"small-molecule kinase inhibitors","score":0.7360000014305115},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.906000018119812},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/carcinoma","display_name":"carcinoma","score":0.8109999895095825},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.9499976634979248},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6645048260688782},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6576681137084961},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6482406854629517},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5802099108695984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5363674163818359},{"id":"https://openalex.org/C2910739307","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"Hepatocyte Growth Factor Receptor","level":5,"score":0.514207124710083},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44650697708129883},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4209405779838562},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.41452616453170776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4061163067817688},{"id":"https://openalex.org/C2780467284","wikidata":"https://www.wikidata.org/wiki/Q5005897","display_name":"C-Met","level":4,"score":0.38456201553344727},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3334561586380005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30755865573883057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13976013660430908}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14617781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14617781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"mag:2189233644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14617781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W295899822","https://openalex.org/W1480076252","https://openalex.org/W1967297996","https://openalex.org/W1973966923","https://openalex.org/W1985562847","https://openalex.org/W1990922168","https://openalex.org/W1992388470","https://openalex.org/W1994422135","https://openalex.org/W2001446321","https://openalex.org/W2007904495","https://openalex.org/W2014201245","https://openalex.org/W2019871776","https://openalex.org/W2042919832","https://openalex.org/W2045765206","https://openalex.org/W2048797151","https://openalex.org/W2050274692","https://openalex.org/W2059250591","https://openalex.org/W2080519213","https://openalex.org/W2085806496","https://openalex.org/W2113791134","https://openalex.org/W2119738345","https://openalex.org/W2121371052","https://openalex.org/W2126890008","https://openalex.org/W2127287125","https://openalex.org/W2148457804","https://openalex.org/W2157959228","https://openalex.org/W2161734258","https://openalex.org/W2166927748","https://openalex.org/W2166952908","https://openalex.org/W2170846037","https://openalex.org/W2171091535","https://openalex.org/W2334802216","https://openalex.org/W2408908877","https://openalex.org/W2473185292","https://openalex.org/W2796575992"],"related_works":["https://openalex.org/W7099589493","https://openalex.org/W2408908877","https://openalex.org/W2094337993","https://openalex.org/W2416717232","https://openalex.org/W2117909405","https://openalex.org/W2622145003","https://openalex.org/W2793669837","https://openalex.org/W1992031126","https://openalex.org/W2144187284","https://openalex.org/W2075092141"],"abstract_inverted_index":{"The":[0],"hepatocyte":[1],"growth":[2],"factor/scatter":[3],"factor":[4],"(HGF/SF)":[5],"receptor,":[6],"Met,":[7],"mediates":[8],"various":[9],"cellular":[10,94],"responses":[11,95],"on":[12],"activation":[13,39],"with":[14,41,144],"its":[15],"ligand,":[16],"including":[17],"proliferation,":[18],"survival,":[19],"motility,":[20],"invasion,":[21],"and":[22,32,45,79,85,114,118,137],"tubular":[23],"morphogenesis.":[24],"Met":[25,38,53,82,135],"expression":[26],"is":[27],"frequently":[28],"up-regulated":[29],"in":[30,96,104,148],"sarcomas":[31],"carcinomas.":[33],"Experimental":[34],"evidence":[35],"suggests":[36],"that":[37,68,131],"correlates":[40],"poor":[42],"clinical":[43],"outcome":[44],"the":[46,60,72,111,134],"likelihood":[47],"of":[48,52,62,66,116,127,142,150],"metastasis.":[49],"Therefore,":[50,121],"inhibitors":[51,84],"tyrosine":[54],"kinase":[55,83,136],"may":[56],"be":[57],"useful":[58],"for":[59,88],"treatment":[61,149],"a":[63,105,125],"wide":[64],"variety":[65],"cancers":[67],"have":[69,76],"spread":[70],"from":[71],"primary":[73],"site.":[74],"We":[75],"discovered":[77],"potent":[78],"selective":[80],"pyrrole-indolinone":[81],"characterized":[86],"them":[87],"their":[89],"ability":[90],"to":[91,140],"inhibit":[92,100,110,133],"HGF/SF-induced":[93,101,112],"vitro.":[97],"These":[98],"compounds":[99,123,143],"receptor":[102],"phosphorylation":[103],"dose-dependent":[106],"manner.":[107],"They":[108],"also":[109],"motility":[113],"invasion":[115],"epithelial":[117],"carcinoma":[119],"cells.":[120],"these":[122],"represent":[124],"class":[126],"prototype":[128],"small":[129],"molecules":[130],"selectively":[132],"could":[138],"lead":[139],"identification":[141],"potential":[145],"therapeutic":[146],"utility":[147],"cancers.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
