{"id":"https://openalex.org/W2189194968","doi":null,"title":"IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients.","display_name":"IgE cross reactivity between reindeer and bovine milk beta-lactoglobulins in cow's milk allergic patients.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2189194968","mag":"2189194968","pmid":"https://pubmed.ncbi.nlm.nih.gov/17039668"},"language":"en","primary_location":{"id":"pmid:17039668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17039668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056991261","display_name":"Suutari Tj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T J Suutari","raw_affiliation_strings":["Laboratory of Biotechnology, Kajaani University Consortium, University of Oulu, Sotkamo, Finland. tiina.suutari@oulu.fi","Laboratory of Biotechnology, Kajaani University Consortium, University of Oulu, Sotkamo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biotechnology, Kajaani University Consortium, University of Oulu, Sotkamo, Finland. tiina.suutari@oulu.fi","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Laboratory of Biotechnology, Kajaani University Consortium, University of Oulu, Sotkamo, Finland","institution_ids":["https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008934236","display_name":"Valkonen Kh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K H Valkonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077468190","display_name":"Tuomo J. Karttunen","orcid":"https://orcid.org/0000-0002-8843-7957","observed_orcids":["https://orcid.org/0000-0002-8843-7957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Karttunen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023109526","display_name":"Britt-Marie Ehn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M Ehn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015459018","display_name":"Bo Ekstrand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Ekstrand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065812072","display_name":"Ulf J. Bengtsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Bengtsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110286679","display_name":"Virtanen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Virtanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086476690","display_name":"Mauri Nieminen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Nieminen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025311140","display_name":"Jorma Kokkonen","orcid":"https://orcid.org/0009-0003-3833-7303","observed_orcids":["https://orcid.org/0009-0003-3833-7303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kokkonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6813,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.80826842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"5","first_page":"296","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cow-s-milk-allergy","display_name":"cow's milk allergy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/beta-lactoglobulin","display_name":"\u03b2-lactoglobulin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cow-s-milk","display_name":"cow's milk","score":0.871999979019165},{"id":"https://openalex.org/keywords/ige-cross-reactivity","display_name":"IgE cross-reactivity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/allergen-epitopes","display_name":"allergen epitopes","score":0.574999988079071},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.49300000071525574},{"id":"https://openalex.org/keywords/milk-allergens","display_name":"milk allergens","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2992940123","wikidata":"https://www.wikidata.org/wiki/Q8495","display_name":"Bovine milk","level":2,"score":0.6950176954269409},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.6828393936157227},{"id":"https://openalex.org/C2781372412","wikidata":"https://www.wikidata.org/wiki/Q970203","display_name":"Milk allergy","level":4,"score":0.6429552435874939},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6107645630836487},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5832469463348389},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5260565280914307},{"id":"https://openalex.org/C2779142602","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross-reactivity","level":4,"score":0.5183137655258179},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.511228084564209},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5024280548095703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35870683193206787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3416104018688202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34052419662475586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23645839095115662},{"id":"https://openalex.org/C3020064264","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross reactions","level":3,"score":0.21712490916252136}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007782","descriptor_name":"Lactoglobulins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012053","descriptor_name":"Reindeer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016269","descriptor_name":"Milk Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:17039668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17039668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.537.260","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.537.260","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jiaci.org/issues/vol16issue05/5.pdf","raw_type":"text"},{"id":"mag:2189194968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17039668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1526442591","https://openalex.org/W1929218437","https://openalex.org/W1975107332","https://openalex.org/W2007286654","https://openalex.org/W2007827343","https://openalex.org/W2011150760","https://openalex.org/W2018601267","https://openalex.org/W2022679357","https://openalex.org/W2030212989","https://openalex.org/W2040141270","https://openalex.org/W2049552318","https://openalex.org/W2063143661","https://openalex.org/W2066615579","https://openalex.org/W2071990722","https://openalex.org/W2074760893","https://openalex.org/W2080381790","https://openalex.org/W2082611727","https://openalex.org/W2085763743","https://openalex.org/W2098831680","https://openalex.org/W2111876811","https://openalex.org/W2117688259","https://openalex.org/W2125477615","https://openalex.org/W2135134206","https://openalex.org/W2283043446","https://openalex.org/W2299038488","https://openalex.org/W2500148628","https://openalex.org/W2784980168"],"related_works":["https://openalex.org/W7095302030","https://openalex.org/W4291314174","https://openalex.org/W2085763743","https://openalex.org/W2161809908","https://openalex.org/W2014386597","https://openalex.org/W1985618772","https://openalex.org/W2149821540","https://openalex.org/W2021552734","https://openalex.org/W2024176288","https://openalex.org/W2030731862"],"abstract_inverted_index":{"BACKGROUND:":[0],"Allergic":[1],"reactions":[2],"to":[3,50,64,139,158,183],"cow's":[4,19,61,83],"milk":[5,20,27,62,93,135],"are":[6,207,209],"common":[7],"in":[8,18,96],"small":[9],"children.":[10],"One":[11],"of":[12,36,46,55,78,119,133,155,174,190],"the":[13,34,52,116,125,159,180],"main":[14],"protein":[15],"allergens":[16],"found":[17],"is":[21],"beta-lactoglobulin":[22],"(beta-Lg).":[23],"Reindeer":[24],"and":[25,66,74,91,99,115,121,204],"bovine":[26,67,90,122,134,164,184,202],"both":[28],"contain":[29],"related":[30],"beta-Lg":[31,38,108,123,136,141,148,165,176,196],"proteins,":[32],"but":[33],"allergenicity":[35],"reindeer":[37,65,92,120,140,147,175,195],"has":[39],"not":[40],"previously":[41],"been":[42],"studied.":[43],"The":[44,187],"purpose":[45],"this":[47],"study":[48],"was":[49,94,105,109],"analyze":[51],"immunological":[53],"cross-reactivity":[54,189],"IgE":[56,85,126,138,156,181,193],"antibodies":[57],"from":[58,71,89],"children":[59,73],"with":[60,81,194],"allergy":[63],"beta-Lg.":[68,185],"METHODS:":[69],"Sera":[70],"17":[72],"a":[75,112],"serum":[76],"pool":[77],"4":[79],"patients":[80],"elevated":[82],"milk-specific":[84],"were":[86,128],"investigated.":[87],"Beta-Lg":[88],"isolated":[95],"native":[97],"form":[98],"an":[100],"enzyme-linked":[101],"immunosorbent":[102],"inhibition":[103,152],"assay":[104],"developed.":[106],"Bovine":[107],"used":[110],"as":[111],"capturing":[113,160],"antigen":[114,161],"inhibiting":[117],"effects":[118],"on":[124],"binding":[127,157,182],"measured.":[129],"RESULTS:":[130],"Cross-reactivity":[131],"patterns":[132],"specific":[137],"varied":[142],"among":[143],"patients.":[144],"In":[145,168],"general,":[146],"showed":[149],"significantly":[150],"lower":[151],"(mean":[153,166],"43%)":[154],"than":[162],"did":[163],"89%).":[167],"some":[169],"patients,":[170],"even":[171],"high":[172],"concentrations":[173],"only":[177,210],"partly":[178],"eliminated":[179],"CONCLUSIONS:":[186],"partial":[188],"human":[191],"anti-bovine":[192],"suggests":[197],"that":[198,206],"it":[199],"lacks":[200],"important":[201],"epitopes":[203],"those":[205],"recognized":[208],"weakly":[211],"bound.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}