{"id":"https://openalex.org/W2189177149","doi":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","title":"Niflumic acid differentially modulates two types of skeletal ryanodine-sensitive Ca2+-release channels","display_name":"Niflumic acid differentially modulates two types of skeletal ryanodine-sensitive Ca2+-release channels","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W2189177149","doi":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","mag":"2189177149","pmid":"https://pubmed.ncbi.nlm.nih.gov/9374644"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1997.273.5.c1588","doi":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111799738","display_name":"Toshiharu \u00d4ba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiharu Oba","raw_affiliation_strings":["Department of Physiology, Nagoya City University Medical School, Nagoya 467, Japan","1 Department of Physiology, Nagoya City University Medical School, Nagoya 467, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya City University Medical School, Nagoya 467, Japan","institution_ids":["https://openalex.org/I33858575"]},{"raw_affiliation_string":"1 Department of Physiology, Nagoya City University Medical School, Nagoya 467, Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111799738"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":null,"apc_paid":null,"fwci":0.2977,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.46184482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"273","issue":"5","first_page":"C1588","last_page":"C1595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niflumic-acid","display_name":"niflumic acid","score":1.0},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.8899999856948853},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9539999961853027},{"id":"https://openalex.org/keywords/calcium-release-channel","display_name":"calcium release channel","score":0.8159999847412109},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.46799999475479126},{"id":"https://openalex.org/keywords/open-probability","display_name":"open probability","score":0.8740000128746033},{"id":"https://openalex.org/keywords/perchlorate","display_name":"perchlorate","score":0.6909999847412109},{"id":"https://openalex.org/keywords/channel-rectification","display_name":"channel rectification","score":0.7379999756813049},{"id":"https://openalex.org/keywords/single-channel-conductance","display_name":"single-channel conductance","score":0.7549999952316284},{"id":"https://openalex.org/keywords/channel-inactivation","display_name":"channel inactivation","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2779700409","wikidata":"https://www.wikidata.org/wiki/Q304285","display_name":"Niflumic acid","level":2,"score":0.9931089878082275},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.8936941623687744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7593734264373779},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6247037053108215},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5030717253684998},{"id":"https://openalex.org/C2779657890","wikidata":"https://www.wikidata.org/wiki/Q424006","display_name":"Ruthenium red","level":3,"score":0.4266871213912964},{"id":"https://openalex.org/C2779996123","wikidata":"https://www.wikidata.org/wiki/Q5198954","display_name":"Cyclopiazonic acid","level":3,"score":0.42164134979248047},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3363470435142517},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.30788514018058777},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.27515122294425964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08719319105148315},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009544","descriptor_name":"Niflumic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010472","descriptor_name":"Perchlorates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011892","descriptor_name":"Rana catesbeiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012430","descriptor_name":"Ruthenium Red","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017670","descriptor_name":"Sodium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019837","descriptor_name":"Ryanodine Receptor Calcium Release Channel","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1997.273.5.c1588","doi":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1997.273.5.c1588","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:9374644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9374644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1525891657","https://openalex.org/W1607072958","https://openalex.org/W1835419280","https://openalex.org/W1840022026","https://openalex.org/W1914131776","https://openalex.org/W1947692468","https://openalex.org/W1964443900","https://openalex.org/W1972823724","https://openalex.org/W1986128184","https://openalex.org/W1986897813","https://openalex.org/W2006149132","https://openalex.org/W2014856276","https://openalex.org/W2020392997","https://openalex.org/W2039547987","https://openalex.org/W2047974033","https://openalex.org/W2066583873","https://openalex.org/W2070205556","https://openalex.org/W2073608912","https://openalex.org/W2076408588","https://openalex.org/W2085326980","https://openalex.org/W2096827547","https://openalex.org/W2113764092","https://openalex.org/W2119956322","https://openalex.org/W2128113643","https://openalex.org/W2131310568","https://openalex.org/W2138450406","https://openalex.org/W2358927500","https://openalex.org/W2411812279","https://openalex.org/W2416369635","https://openalex.org/W2432263744","https://openalex.org/W2432916952"],"related_works":["https://openalex.org/W2432263744","https://openalex.org/W1972823724","https://openalex.org/W2266500960","https://openalex.org/W1964443900","https://openalex.org/W2055779520","https://openalex.org/W2139705563","https://openalex.org/W2032384023","https://openalex.org/W1581695074","https://openalex.org/W4247775974","https://openalex.org/W2133811695"],"abstract_inverted_index":{"The":[0,85,147],"effects":[1,149],"of":[2,9,31,91,132,150,163,174],"niflumic":[3,47,75,100,125,151],"acid":[4,101,126,152],"on":[5,80,153],"ryanodine":[6],"receptors":[7],"(RyRs)":[8],"frog":[10],"skeletal":[11],"muscle":[12,26],"were":[13,95],"studied":[14],"by":[15,57],"incorporating":[16],"sarcoplasmic":[17],"reticulum":[18],"(SR)":[19],"vesicles":[20],"into":[21],"planar":[22],"lipid":[23],"bilayers.":[24],"Frog":[25],"had":[27],"two":[28],"distinct":[29,178],"types":[30,94,162],"RyRs":[32],"in":[33,160],"the":[34,65,113,120,130,156,169,172],"SR:":[35],"one":[36],"showed":[37,67],"a":[38,68],"bell-shaped":[39],"channel":[40,93,116,138],"activation":[41,70],"curve":[42,71],"against":[43,72],"cytoplasmic":[44],"Ca2+":[45,73,136],"or":[46,74,171],"acid,":[48,76],"and":[49,88,144,155],"its":[50],"mean":[51],"open":[52],"probability":[53],"(Po)":[54],"was":[55],"increased":[56],"perchlorate":[58,81],"at":[59,104,109],"20-30":[60],"mM":[61],"(termed":[62,82],"\"alpha-like\"":[63],"RyR);":[64],"other":[66],"sigmoidal":[69],"with":[77,124],"no":[78],"effect":[79],"\"beta-like\"":[83],"RyR).":[84],"unitary":[86,121,157],"conductance":[87],"reversal":[89],"potential":[90],"both":[92,133,161],"unaffected":[96],"after":[97],"exposure":[98],"to":[99,135,168,180],"when":[102],"clamped":[103,108],"0":[105],"mV.":[106],"When":[107],"more":[110],"positive":[111],"potentials,":[112],"beta-like":[114],"RyR":[115],"rectified":[117],"this,":[118],"increasing":[119],"current.":[122],"Treatment":[123],"did":[127],"not":[128],"inhibit":[129],"response":[131],"channels":[134,164],"release":[137],"modulators":[139],"such":[140],"as":[141],"caffeine,":[142],"ryanodine,":[143],"ruthenium":[145],"red.":[146],"different":[148],"Po":[154],"current":[158],"amplitude":[159],"may":[165],"be":[166],"attributable":[167],"lack":[170],"presence":[173],"inactivation":[175],"sites":[176],"and/or":[177],"responses":[179],"agonists.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
