{"id":"https://openalex.org/W2189176629","doi":null,"title":"Effect of topiramate on apoptosis-related protein expression of hippocampus in model rats with Alzheimers disease.","display_name":"Effect of topiramate on apoptosis-related protein expression of hippocampus in model rats with Alzheimers disease.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2189176629","mag":"2189176629","pmid":"https://pubmed.ncbi.nlm.nih.gov/24706297"},"language":"en","primary_location":{"id":"pmid:24706297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24706297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004724105","display_name":"Cheng Xl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177739611","display_name":"Yangtze University","ror":"https://ror.org/05bhmhz54","country_code":"CN","type":"education","lineage":["https://openalex.org/I177739611"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X-L Cheng","raw_affiliation_strings":["Department of Neurology, Hospital of Yangtze University, Hubei, China. 5298856@qq.com \u00a0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Hospital of Yangtze University, Hubei, China. 5298856@qq.com \u00a0","institution_ids":["https://openalex.org/I177739611"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084114792","display_name":"Li Mk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M-K Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1011,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.72734932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"18","issue":"6","first_page":"761","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topiramate","display_name":"topiramate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.7549999952316284},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.890999972820282},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.5260000228881836},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.8324122428894043},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.758983850479126},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6576627492904663},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.6350902915000916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5770825147628784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5766280889511108},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5139355063438416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46174365282058716},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.46104001998901367},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4553419351577759},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.331592857837677},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31436699628829956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25151538848876953},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13972002267837524},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08971643447875977},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.06024801731109619},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077022","descriptor_name":"Survivin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077236","descriptor_name":"Topiramate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24706297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24706297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:2189176629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24706297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1533054883","https://openalex.org/W1587632330","https://openalex.org/W1969271586","https://openalex.org/W1985972305","https://openalex.org/W1990518612","https://openalex.org/W1990752558","https://openalex.org/W2028774417","https://openalex.org/W2035500729","https://openalex.org/W2047649942","https://openalex.org/W2047816313","https://openalex.org/W2072944042","https://openalex.org/W2080284013","https://openalex.org/W2085615781","https://openalex.org/W2090054406","https://openalex.org/W2092597346","https://openalex.org/W2096410114","https://openalex.org/W2103278596","https://openalex.org/W2108938583","https://openalex.org/W2138174194","https://openalex.org/W2156247910","https://openalex.org/W2168334242","https://openalex.org/W2170785011"],"related_works":["https://openalex.org/W2352626963","https://openalex.org/W2949429530","https://openalex.org/W2381519312","https://openalex.org/W2064087822","https://openalex.org/W2963893940","https://openalex.org/W2366873451","https://openalex.org/W3161030255","https://openalex.org/W4310497399","https://openalex.org/W2259597297","https://openalex.org/W2361257876"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Alzheimer's":[1,230],"disease":[2,7,231],"is":[3],"an":[4,125],"age-related":[5],"neurodegenerative":[6],"and":[8,45,75,97,100,156,160,193,197,256,258,264],"a":[9,51,69,72,76],"synaptic":[10],"function":[11],"defect":[12],"disease,":[13],"the":[14,33,48,89,92,95,101,117,140,214],"clinical":[15],"symptoms":[16],"are":[17,104],"mainly":[18],"progressive":[19],"cognitive":[20],"impairment,":[21],"affecting":[22],"patient's":[23],"social":[24],"function.":[25],"Aim":[26],"of":[27,35,50,81,91,109,128,137,154,165,174,183,202,211,221,235,244,254,261],"this":[28],"report":[29],"was":[30,86,114,147,170,207],"to":[31],"investigate":[32],"effect":[34,136],"topiramate":[36,129,138],"on":[37,139],"apoptosis-related":[38,141],"protein":[39,142],"expression":[40,253,260],"(Bcl-2,":[41],"Survivin,":[42],"Fas,":[43,191,262],"Bax":[44,192,263],"Caspase-3)":[46],"in":[47,94,119,144,163,167,176,185,200,204,213,223,238,249],"hippocampus":[49,90,145,164,201,236,245],"rat":[52],"model":[53,73,96,113,177,215],"with":[54,106,124],"Alzheimers":[55],"Disease":[56],"(AD).":[57],"MATERIALS":[58],"AND":[59],"METHODS:":[60],"Thirty-six":[61],"adult":[62],"Wistar":[63],"rats":[64,93,103,118,166,175,184,203,212,222],"were":[65,122],"randomly":[66],"divided":[67],"into":[68,88],"control":[70,102,186,224],"group,":[71,216],"group":[74,121,169,187,206,225],"test":[77,98,168,205],"group.":[78],"A":[79],"dose":[80],"amyloid":[82],"beta-protein":[83],"1-40":[84],"(A\u03b21-40)":[85],"injected":[87,105],"groups,":[99,178],"same":[107],"amount":[108],"saline.":[110],"After":[111],"AD":[112],"successfully":[115],"established,":[116],"each":[120],"administrated":[123],"i.p.":[126],"injection":[127],"(20":[130],"mg/kg/d)":[131],"for":[132],"30":[133],"days.":[134],"The":[135,152],"levels":[143],"neurons":[146,237],"studied":[148],"by":[149,251],"immunohistochemistry.":[150],"RESULTS:":[151],"number":[153],"Bcl-2":[155,255],"Survivin":[157,257],"positive":[158,195],"cells":[159,196],"optical":[161,198],"density":[162,199],"more":[171,218],"than":[172,181,209,219],"those":[173,182,210,220],"but":[179,217],"less":[180,208],"(p":[188,226],"<":[189,227],"0.01);":[190],"Caspase-3":[194],"0.01).":[228],"CONCLUSIONS:":[229],"can":[232,241],"induce":[233],"apoptosis":[234,243],"rats.":[239],"Topiramate":[240],"prevent":[242],"neurons,":[246],"at":[247],"least":[248],"part,":[250],"increasing":[252],"decreasing":[259],"Caspase-3.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
