{"id":"https://openalex.org/W2189154114","doi":null,"title":"Evaluation of Novel Biomarkers for Coronary Artery Disease among Symptomatic Patients: Statistical Methodology and Application","display_name":"Evaluation of Novel Biomarkers for Coronary Artery Disease among Symptomatic Patients: Statistical Methodology and Application","publication_year":2013,"publication_date":"2013-06-27","ids":{"openalex":"https://openalex.org/W2189154114","mag":"2189154114"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:18477","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112750765","display_name":"Daniel Lans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Lans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112750765"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.1429000049829483,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biomarker-panel","display_name":"biomarker panel","score":0.7519999742507935},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.5659999847412109},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7059999704360962},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.949999988079071},{"id":"https://openalex.org/keywords/blood-based-diagnostics","display_name":"blood-based diagnosis","score":0.5230000019073486},{"id":"https://openalex.org/keywords/clinical-risk-factors","display_name":"clinical risk factors","score":0.8029999732971191},{"id":"https://openalex.org/keywords/multivariate-logistic-regression","display_name":"multivariate logistic regression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8564411401748657},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.7379106283187866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6072149276733398},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5839783549308777},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5775870084762573},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5677264332771301},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.497254878282547},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4248407185077667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:18477","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2189154114","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:18477","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","pdf_url":"http://d-scholarship.pitt.edu/18477/1/Lans_D_Thesis_2013.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2189154114.pdf","grobid_xml":"https://content.openalex.org/works/W2189154114.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W91108901","https://openalex.org/W187372838","https://openalex.org/W350025413","https://openalex.org/W1509445416","https://openalex.org/W1521514415","https://openalex.org/W1554797744","https://openalex.org/W1554944419","https://openalex.org/W1963947272","https://openalex.org/W1967262562","https://openalex.org/W1970354828","https://openalex.org/W1982295091","https://openalex.org/W1984769712","https://openalex.org/W1991323299","https://openalex.org/W1995683403","https://openalex.org/W1996207491","https://openalex.org/W2009353196","https://openalex.org/W2010444010","https://openalex.org/W2015902483","https://openalex.org/W2045161311","https://openalex.org/W2050856345","https://openalex.org/W2051842535","https://openalex.org/W2052006449","https://openalex.org/W2068138485","https://openalex.org/W2079661788","https://openalex.org/W2080564894","https://openalex.org/W2080694099","https://openalex.org/W2096217402","https://openalex.org/W2105087430","https://openalex.org/W2107424758","https://openalex.org/W2108207895","https://openalex.org/W2108842111","https://openalex.org/W2110065044","https://openalex.org/W2115151376","https://openalex.org/W2150369922","https://openalex.org/W2151797643","https://openalex.org/W2154601514","https://openalex.org/W2158698691","https://openalex.org/W2168692593","https://openalex.org/W2297716127","https://openalex.org/W2322822079","https://openalex.org/W2327470041","https://openalex.org/W2409903368","https://openalex.org/W2606898602"],"related_works":["https://openalex.org/W2899183678","https://openalex.org/W4385371268","https://openalex.org/W2048864018","https://openalex.org/W2360809840","https://openalex.org/W2784997672","https://openalex.org/W1979215997","https://openalex.org/W2131950847","https://openalex.org/W4282970403","https://openalex.org/W6921131939","https://openalex.org/W2610370368"],"abstract_inverted_index":{"Proteomics":[0],"has":[1],"led":[2],"to":[3,40,54,79,87,117,144,171,197,219,298],"the":[4,18,32,38,55,59,80,88,146,151,224,227,230,241,252,266,270,285,302,305],"discovery":[5],"of":[6,24,34,74,105,111,150,163,176,223,229,235,243,254,269,287,304],"several":[7],"biomarkers":[8,26,112],"within":[9],"an":[10,69],"individual\u2019s":[11],"bloodstream":[12],"that":[13,45,50,113,200],"can":[14,114,250],"be":[15,115,172,279,299],"used":[16,116,133,211],"in":[17,31,91,134,180],"diagnostic":[19,43,61],"process":[20],"for":[21,63,141,186,240],"disease.":[22],"Identification":[23],"novel":[25],"have":[27,203],"a":[28,92,109,181,236,275,289],"significant":[29,174],"impact":[30],"area":[33],"public":[35],"health,":[36],"with":[37,120,126,136,156,226,265,273,291],"potential":[39],"replace":[41],"existing":[42],"methods":[44],"are":[46],"complicated,":[47],"costly,":[48],"and":[49,103,124,167,192,261,284],"pose":[51],"considerable":[52],"risk":[53,139,188,213],"patient.":[56],"Cardiac":[57],"catheterization,":[58],"current":[60],"method":[62],"coronary":[64,121,128,177,206,244,294],"artery":[65,122,178,245,295],"disease,":[66],"is":[67,90],"such":[68,274],"invasive":[70,267],"procedure.":[71,271],"An":[72],"over-abundance":[73],"negative":[75],"test":[76,239],"results":[77],"leads":[78],"inquiry":[81],"whether":[82],"exposing":[83],"all":[84],"symptomatic":[85,248],"patients":[86,199,249],"procedure":[89],"physician\u2019s":[93],"best":[94],"interest.":[95],"A":[96,159],"statistical":[97],"analysis":[98],"involving":[99],"multivariate":[100],"logistic":[101,183],"regression":[102],"evaluation":[104],"predictive":[106,148,182],"models":[107],"identified":[108],"panel":[110,131,153,161],"classify":[118],"patient":[119,262,290],"disease":[123,143,179,207,246,296],"those":[125],"\u201cnormal\u201d":[127],"arteries.":[129],"This":[130],"was":[132],"conjunction":[135],"common":[137],"clinical":[138,157,187,212],"factors":[140,214],"heart":[142],"examine":[145],"added":[147],"power":[149],"multi-marker":[152],"when":[154],"combined":[155],"characteristics.":[158],"four-marker":[160],"consisting":[162],"OPN,":[164],"IL1\u03b2,":[165],"Apo-B100,":[166],"Fibrinogen":[168],"were":[169],"found":[170],"statistically":[173],"predictors":[175],"model":[184],"adjusting":[185],"factors,":[189],"diabetes":[190],"status":[191],"smoking":[193],"status.":[194],"The":[195,233],"ability":[196],"identify":[198],"did":[201],"not":[202],"clinically":[204,292],"relevant":[205,293],"based":[208],"on":[209],"currently":[210],"increased":[215],"greatly,":[216],"from":[217],"zero":[218],"approximately":[220],"thirty":[221],"percent":[222],"patients,":[225],"inclusion":[228],"biomarker":[231],"panel.":[232],"use":[234],"blood":[237],"screening":[238],"diagnosis":[242],"among":[247],"limit":[251],"number":[253],"unnecessary":[255],"cardiac":[256],"catheterizations,":[257],"reducing":[258],"healthcare":[259],"costs":[260],"risks":[263],"associated":[264],"nature":[268],"However,":[272],"test,":[276],"there":[277],"may":[278],"some":[280],"discrimination":[281],"error":[282],"present,":[283],"cost":[286],"misdiagnosing":[288],"needs":[297],"weighed":[300],"against":[301],"benefits":[303],"test.":[306]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}