{"id":"https://openalex.org/W2189043467","doi":null,"title":"The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation","display_name":"The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation","publication_year":2009,"publication_date":"2009-05-05","ids":{"openalex":"https://openalex.org/W2189043467","mag":"2189043467"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/32331","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/32331","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/9c24527d-a164-44ee-a0ea-b779d8a2f729/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://vtechworks.lib.vt.edu/bitstreams/9c24527d-a164-44ee-a0ea-b779d8a2f729/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041903488","display_name":"Youjia Fang","orcid":"https://orcid.org/0000-0003-4359-5983","observed_orcids":["https://orcid.org/0000-0003-4359-5983"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Youjia Fang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4359-5983","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041903488"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irak1","display_name":"IRAK1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/obesity-induced-inflammation","display_name":"obesity-associated inflammation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/glycogen-synthesis","display_name":"glycogen synthesis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/glycogen-synthase","display_name":"glycogen synthase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8479999899864197},{"id":"https://openalex.org/keywords/atf1","display_name":"ATF1","score":0.9860000014305115},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7350872755050659},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.649312436580658},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5524979829788208},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48078054189682007},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.46528831124305725},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.44010215997695923},{"id":"https://openalex.org/C2777977768","wikidata":"https://www.wikidata.org/wiki/Q15996698","display_name":"Interleukin-1 receptor","level":4,"score":0.42858392000198364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37125349044799805},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.3700973391532898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3332679867744446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3111204206943512},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25409483909606934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21572420001029968}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/32331","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/32331","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/9c24527d-a164-44ee-a0ea-b779d8a2f729/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2189043467","doi":null,"is_oa":false,"landing_page_url":"https://scholar.lib.vt.edu/theses/available/etd-05072009-114808/unrestricted/thesis1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/32331","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/32331","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/9c24527d-a164-44ee-a0ea-b779d8a2f729/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2189043467.pdf","grobid_xml":"https://content.openalex.org/works/W2189043467.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W10482017","https://openalex.org/W28253242","https://openalex.org/W1485363052","https://openalex.org/W1494495256","https://openalex.org/W1499902555","https://openalex.org/W1505106993","https://openalex.org/W1531537331","https://openalex.org/W1551443142","https://openalex.org/W1560653098","https://openalex.org/W1573704377","https://openalex.org/W1592353043","https://openalex.org/W1697523131","https://openalex.org/W1831189467","https://openalex.org/W1872118948","https://openalex.org/W1874223625","https://openalex.org/W1925157258","https://openalex.org/W1963938144","https://openalex.org/W1971379086","https://openalex.org/W1972739692","https://openalex.org/W1973417966","https://openalex.org/W1974033843","https://openalex.org/W1974186712","https://openalex.org/W1976424894","https://openalex.org/W1979292977","https://openalex.org/W1981025527","https://openalex.org/W1983055247","https://openalex.org/W1989324173","https://openalex.org/W1995122533","https://openalex.org/W1998493448","https://openalex.org/W1999136265","https://openalex.org/W2003115478","https://openalex.org/W2004986546","https://openalex.org/W2007009178","https://openalex.org/W2008869160","https://openalex.org/W2012039807","https://openalex.org/W2014033824","https://openalex.org/W2014120138","https://openalex.org/W2014415555","https://openalex.org/W2015472023","https://openalex.org/W2022801078","https://openalex.org/W2025621891","https://openalex.org/W2028242823","https://openalex.org/W2031637294","https://openalex.org/W2033529039","https://openalex.org/W2034357937","https://openalex.org/W2035217892","https://openalex.org/W2038018821","https://openalex.org/W2040706148","https://openalex.org/W2041521914","https://openalex.org/W2046741925","https://openalex.org/W2048272608","https://openalex.org/W2058138221","https://openalex.org/W2061873998","https://openalex.org/W2064846840","https://openalex.org/W2067678108","https://openalex.org/W2068252839","https://openalex.org/W2069981713","https://openalex.org/W2071889908","https://openalex.org/W2072346277","https://openalex.org/W2073304650","https://openalex.org/W2076361525","https://openalex.org/W2078665434","https://openalex.org/W2078807483","https://openalex.org/W2082387343","https://openalex.org/W2083308747","https://openalex.org/W2088359631","https://openalex.org/W2089938437","https://openalex.org/W2095680175","https://openalex.org/W2097838137","https://openalex.org/W2103289021","https://openalex.org/W2107551117","https://openalex.org/W2108546663","https://openalex.org/W2113184924","https://openalex.org/W2114918609","https://openalex.org/W2123194197","https://openalex.org/W2124432707","https://openalex.org/W2126440278","https://openalex.org/W2127642399","https://openalex.org/W2127985487","https://openalex.org/W2129319296","https://openalex.org/W2130766522","https://openalex.org/W2134847649","https://openalex.org/W2136024338","https://openalex.org/W2137385309","https://openalex.org/W2140664543","https://openalex.org/W2145803213","https://openalex.org/W2152869893","https://openalex.org/W2157620039","https://openalex.org/W2159990074","https://openalex.org/W2171260427","https://openalex.org/W2403807317","https://openalex.org/W2442275722","https://openalex.org/W2912401569","https://openalex.org/W4300853505"],"related_works":["https://openalex.org/W2809014090","https://openalex.org/W2621223949","https://openalex.org/W2112620654","https://openalex.org/W3114473221","https://openalex.org/W7099114213","https://openalex.org/W2895428233","https://openalex.org/W2078665434","https://openalex.org/W2088456450","https://openalex.org/W2016155391","https://openalex.org/W2030618676"],"abstract_inverted_index":{"Obesity-induced":[0],"chronic":[1],"inflammation":[2,55],"plays":[3,50],"a":[4,40],"key":[5],"role":[6,53],"in":[7,23,44,54,96,99,156,178],"the":[8,14,69,105,127,157],"pathogenesis":[9],"of":[10,72,130,159],"insulin":[11,21,32,79],"resistance":[12,22],"and":[13,28,49,56,80,98,113,138,163,168,193,211],"metabolic":[15],"syndrome.":[16],"Proinflammatory":[17],"cytokines":[18],"can":[19,90],"cause":[20],"adipose":[24],"tissue,":[25],"skeletal":[26],"muscle":[27],"liver":[29],"by":[30,78,165],"inhibiting":[31,134],"signaling":[33,47,75,136],"transduction.":[34],"Interleukin-1":[35],"receptor-associated":[36],"kinase-1":[37],"(IRAK-1)":[38],"is":[39,66,124,154],"serine/threonine":[41],"kinase":[42],"functioning":[43],"Toll-like":[45],"Receptor":[46],"pathways,":[48],"an":[51],"important":[52],"immune":[57],"response.":[58],"In":[59],"our":[60,148,200],"studies,":[61],"we":[62],"demonstrated":[63],"that":[64,88,122,152,202],"IRAK-1":[65,89,123,153,203],"involved":[67,125,155,177,207],"with":[68,92,126,208],"negative":[70,128],"regulation":[71,129],"PI3K-Akt":[73,135],"dependent":[74],"pathway":[76,137],"induced":[77],"TLR":[81],"2&4":[82],"agonists.":[83],"Out":[84],"data":[85],"also":[86,120,150,206],"indicate":[87,121],"interact":[91],"IRS-1":[93],"protein":[94],"both":[95],"vivo":[97],"vitro.":[100],"The":[101],"binding":[102],"sites":[103],"for":[104],"IRAK1-IRS1":[106],"biochemical":[107],"interaction":[108],"are":[109],"IRS-1's":[110],"PH":[111],"domain":[112],"IRAK-1's":[114],"proline-rich":[115],"LWPPPP":[116],"motif.":[117],"Our":[118],"studies":[119,149],"glycogen":[131,145],"synthesis":[132],"through":[133],"thus":[139],"releasing":[140],"GSK3\u03b2's":[141],"inhibitory":[142],"effect":[143],"on":[144],"synthase.":[146],"Moreover,":[147],"suggest":[151],"activation":[158],"transcription":[160,172],"factors":[161],"CREB":[162,171],"ATF-1":[164,169],"stimulating":[166],"CREB-Ser133":[167],"phosphorylation.":[170],"factor":[173,192],"family":[174],"induces":[175],"genes":[176],"cellular":[179],"metabolism,":[180],"gene":[181],"transcription,":[182],"cell":[183,186,209],"cycle":[184],"regulation,":[185],"survival,":[187],"as":[188,190],"well":[189],"growth":[191],"cytokine":[194],"genes.":[195],"That":[196],"may":[197,204],"partially":[198],"explain":[199],"finding":[201],"be":[205],"proliferation":[210],"survival":[212],"pathway.":[213]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}