{"id":"https://openalex.org/W2188989289","doi":null,"title":"Molecular Mechanisms Underlying the Oncogenic Function of SS18 and SSX","display_name":"Molecular Mechanisms Underlying the Oncogenic Function of SS18 and SSX","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2188989289","mag":"2188989289"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26910112","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Molecular_mechanisms_underlying_the_oncogenic_function_of_SS18_and_SSX/26910112","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39336","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030286006","display_name":"P\u00e1draig D\u2019Arcy","orcid":"https://orcid.org/0000-0001-6671-7600","observed_orcids":["https://orcid.org/0000-0001-6671-7600"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P\u00e1draig D\u2019Arcy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6671-7600","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5030286006"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.25929999351501465,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ssx","display_name":"SSX","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/p53-ubiquitination","display_name":"p53 ubiquitination","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.7630000114440918},{"id":"https://openalex.org/keywords/nutlin-3a","display_name":"Nutlin-3a","score":0.9639999866485596},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4390000104904175},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6010763645172119},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5966957211494446},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5186818838119507},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.45603713393211365},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4431523084640503},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4030500054359436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3919883370399475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39026930928230286},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3263649344444275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25176894664764404}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26910112","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Molecular_mechanisms_underlying_the_oncogenic_function_of_SS18_and_SSX/26910112","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39336","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2188989289","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/39336/thesis.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39336","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W88342265","https://openalex.org/W1208928033","https://openalex.org/W1493694909","https://openalex.org/W1500729563","https://openalex.org/W1517116833","https://openalex.org/W1616121322","https://openalex.org/W1640635403","https://openalex.org/W1650797637","https://openalex.org/W1784857457","https://openalex.org/W1856360008","https://openalex.org/W1859765343","https://openalex.org/W1884928119","https://openalex.org/W1894683288","https://openalex.org/W1937607074","https://openalex.org/W1954532037","https://openalex.org/W1965173366","https://openalex.org/W1966790089","https://openalex.org/W1969044026","https://openalex.org/W1969559358","https://openalex.org/W1970207103","https://openalex.org/W1970395545","https://openalex.org/W1970796703","https://openalex.org/W1972805469","https://openalex.org/W1977813278","https://openalex.org/W1979714885","https://openalex.org/W1979849852","https://openalex.org/W1981584846","https://openalex.org/W1982478470","https://openalex.org/W1984466392","https://openalex.org/W1984740535","https://openalex.org/W1984838097","https://openalex.org/W1984959915","https://openalex.org/W1985063313","https://openalex.org/W1986250681","https://openalex.org/W1986850084","https://openalex.org/W1988013021","https://openalex.org/W1993864973","https://openalex.org/W1996121905","https://openalex.org/W1996792476","https://openalex.org/W1998807019","https://openalex.org/W1999310200","https://openalex.org/W2000130466","https://openalex.org/W2002705413","https://openalex.org/W2003653107","https://openalex.org/W2004125341","https://openalex.org/W2004257228","https://openalex.org/W2005575996","https://openalex.org/W2006982588","https://openalex.org/W2007249806","https://openalex.org/W2009266803","https://openalex.org/W2010547510","https://openalex.org/W2012053348","https://openalex.org/W2016656445","https://openalex.org/W2017325023","https://openalex.org/W2018270751","https://openalex.org/W2025035564","https://openalex.org/W2025157990","https://openalex.org/W2025389375","https://openalex.org/W2025855494","https://openalex.org/W2026366604","https://openalex.org/W2027217537","https://openalex.org/W2032460439","https://openalex.org/W2034177818","https://openalex.org/W2035188342","https://openalex.org/W2040056274","https://openalex.org/W2048410022","https://openalex.org/W2048628659","https://openalex.org/W2049202455","https://openalex.org/W2049263560","https://openalex.org/W2049328286","https://openalex.org/W2050179520","https://openalex.org/W2052282189","https://openalex.org/W2055169942","https://openalex.org/W2056793372","https://openalex.org/W2059280732","https://openalex.org/W2063877452","https://openalex.org/W2064726837","https://openalex.org/W2065148309","https://openalex.org/W2067368732","https://openalex.org/W2067801675","https://openalex.org/W2068577315","https://openalex.org/W2068912983","https://openalex.org/W2070916915","https://openalex.org/W2072237399","https://openalex.org/W2072712582","https://openalex.org/W2073671046","https://openalex.org/W2073936529","https://openalex.org/W2075255224","https://openalex.org/W2076147908","https://openalex.org/W2078760369","https://openalex.org/W2079544986","https://openalex.org/W2080243787","https://openalex.org/W2081586744","https://openalex.org/W2081628846","https://openalex.org/W2084069837","https://openalex.org/W2085029239","https://openalex.org/W2085138816","https://openalex.org/W2085195718","https://openalex.org/W2086941386","https://openalex.org/W2088306576","https://openalex.org/W2090319373","https://openalex.org/W2090786982","https://openalex.org/W2091151265","https://openalex.org/W2091818021","https://openalex.org/W2092173590","https://openalex.org/W2094494461","https://openalex.org/W2094838095","https://openalex.org/W2097529756","https://openalex.org/W2097933346","https://openalex.org/W2098935972","https://openalex.org/W2099907467","https://openalex.org/W2102067723","https://openalex.org/W2102140136","https://openalex.org/W2102595806","https://openalex.org/W2104842253","https://openalex.org/W2104968595","https://openalex.org/W2105155498","https://openalex.org/W2108740070","https://openalex.org/W2110942624","https://openalex.org/W2114373487","https://openalex.org/W2115977907","https://openalex.org/W2116914257","https://openalex.org/W2117104103","https://openalex.org/W2118475754","https://openalex.org/W2120132028","https://openalex.org/W2121394959","https://openalex.org/W2126855360","https://openalex.org/W2127423053","https://openalex.org/W2127668594","https://openalex.org/W2132195353","https://openalex.org/W2132628938","https://openalex.org/W2134483979","https://openalex.org/W2135034679","https://openalex.org/W2135300227","https://openalex.org/W2137088550","https://openalex.org/W2138593362","https://openalex.org/W2139973326","https://openalex.org/W2141762576","https://openalex.org/W2143243534","https://openalex.org/W2148297520","https://openalex.org/W2149285292","https://openalex.org/W2151605250","https://openalex.org/W2155978618","https://openalex.org/W2157952439","https://openalex.org/W2160345685","https://openalex.org/W2164263233","https://openalex.org/W2164489545","https://openalex.org/W2165932947","https://openalex.org/W2166213130","https://openalex.org/W2170778160","https://openalex.org/W2172177942","https://openalex.org/W2207680991","https://openalex.org/W2244930776","https://openalex.org/W2314012478","https://openalex.org/W2314361118","https://openalex.org/W2320727010","https://openalex.org/W2329132383","https://openalex.org/W2399883301","https://openalex.org/W2410555345","https://openalex.org/W2414552364","https://openalex.org/W2500363613","https://openalex.org/W2794670533"],"related_works":["https://openalex.org/W2115771116","https://openalex.org/W2311577210","https://openalex.org/W2025847887","https://openalex.org/W2437779439","https://openalex.org/W2134590280","https://openalex.org/W2906024189","https://openalex.org/W2529732872","https://openalex.org/W7095415213","https://openalex.org/W2126855360","https://openalex.org/W2512225853"],"abstract_inverted_index":{"The":[0,57,246],"SS18":[1,28,58],"and":[2,81,98,133,166,185,195,216,231,311,363,386,393,414],"SSX":[3,39,68,143,163,178,190,211,359],"genes":[4,238],"were":[5,285],"initially":[6],"identified":[7],"based":[8],"on":[9,42,249],"their":[10,134],"reoccurrence":[11],"as":[12],"fusion":[13,54,88],"partners":[14],"in":[15,47,129,164,183,186,191,220,271,292,352,391,394,442],"synovial":[16,110,272,328,443],"sarcoma.":[17,111,329],"As":[18],"a":[19,51,61,71,91,149,159,243],"result":[20],"of":[21,37,50,103,109,123,142,155,177,189,208,219,235,242,257,324,331,358,436,447],"the":[22,27,38,43,48,67,85,101,106,114,124,173,182,233,240,255,268,300,316],"specific":[23],"chromosomal":[24],"translocation":[25],"t(X:18),":[26],"gene":[29,40,55,59,69,89],"from":[30],"chromosome":[31,45],"18":[32],"becomes":[33],"fused":[34],"with":[35,94,119,152,299],"members":[36,122],"family":[41,126],"X":[44],"resulting":[46],"generation":[49],"novel":[52],"chimeric":[53],"SS18-SSX.":[56],"encodes":[60,70,90],"ubiquitously":[62],"expressed":[63,128,210],"transcriptional":[64,72,384],"activator,":[65],"whereas":[66],"repressor":[73],"whose":[74],"expression":[75,102,135,157,179,351],"is":[76,105,127,136],"restricted":[77],"to":[78,254,259,294],"germ":[79],"cells":[80,132,284],"numerous":[82],"cancers.":[83],"Thus,":[84],"resultant":[86],"SS18-SSX":[87,226,258],"transcription":[92],"factor":[93],"dual":[95],"trans":[96,290,309],"activation":[97,291,310],"repression":[99],"properties;":[100],"which":[104],"initiating":[107],"event":[108],"We":[112,170,223,262,280],"present":[113],"findings":[115],"that":[116,206,225,282,314],"SSX,":[117],"along":[118],"several":[120],"other":[121],"CT-antigen":[125],"mesenchymal":[130,354],"stem":[131,165,355],"down":[137,153],"regulated":[138],"following":[139,239],"differentiation.":[140],"Knockdown":[141],"could":[144,305],"effectively":[145,306],"impair":[146],"cell":[147,168,193,196,214,274,361,389],"migration,":[148],"phenotype":[150],"associated":[151],"regulation":[154],"MMP2":[156],"adding":[158],"functional":[160],"role":[161,188],"for":[162,287,327],"tumor":[167,217,388,440],"migration.":[169],"further":[171],"explored":[172],"potential":[174],"oncogenic":[175],"mechanism":[176],"by":[180,266,416,445],"investigating":[181],"vitro":[184,392],"vivo":[187,221],"altering":[192],"growth":[194,218],"cycle":[197],"progression.":[198],"Using":[199],"an":[200],"inducible":[201],"siRNA":[202],"system":[203],"we":[204],"show":[205,281],"knockdown":[207],"endogenously":[209],"can":[212,304],"inhibit":[213],"proliferation":[215,390],"xenographs.":[222],"demonstrate":[224],"induces":[227],"p53":[228,236,250,269,289,308,412,439],"ubiquitination,":[229],"degradation":[230,415],"prevents":[232],"transactivation":[234],"target":[237],"induction":[241],"stress":[244],"response.":[245],"negative":[247],"effect":[248],"function":[251,385,441],"was":[252],"attributed":[253],"ability":[256],"stabilize":[260],"HDM2.":[261],"developed":[263],"this":[264],"notion":[265],"studying":[267],"pathway":[270],"sarcoma":[273],"lines":[275],"expressing":[276],"wild":[277,437],"type":[278,438],"p53.":[279],"these":[283],"defective":[286],"inducing":[288],"response":[293],"genotoxic":[295],"stress;":[296],"however":[297],"treatment":[298],"HDM2":[301,318,418],"antagonist":[302],"nutlin-3A":[303],"restore":[307],"apoptosis,":[312],"suggesting":[313],"targeting":[315],"p53-":[317],"auto":[319],"regulatory":[320],"loop":[321],"may":[322],"be":[323],"therapeutic":[325],"benefit":[326],"List":[330],"scientific":[332],"papers":[333],"I.":[334],"Cronwright":[335],"G,":[336],"Le":[337],"Blanc":[338],"K,":[339],"G\u00f6therstr\u00f6m":[340],"C,":[341],"Darcy":[342,376,398,427],"P,":[343,377,399,428],"Ehnman":[344],"M,":[345],"Brodin":[346,378,405,432],"B":[347,403,406,430,433],"(2005).":[348],"\"Cancer/testis":[349],"antigen":[350],"human":[353],"cells:":[356],"down-regulation":[357],"impairs":[360],"migration":[362],"matrix":[364],"metalloproteinase":[365],"2":[366],"expression.\"":[367],"Cancer":[368,421],"Res":[369,422],"65(6):":[370],"2207-15.":[371],"https://pubmed.ncbi.nlm.nih.gov/15781633":[372],"II.":[373],"Maruwge":[374,400],"W,":[375,401],"B.":[379],"(2008).":[380,407,434],"\"SSX":[381],"activates":[382],"beta-catenin":[383],"sustains":[387],"vivo.\"":[395],"[Submitted]":[396,450],"III.":[397],"Ryan":[402,429],"A,":[404,431],"\"The":[408],"oncoprotein":[409],"SS18-SSX1":[410],"promotes":[411],"ubiquitination":[413],"enhancing":[417],"stability.\"":[419],"Mol":[420],"6(1).":[423],"[Accepted]":[424],"https://pubmed.ncbi.nlm.nih.gov/18234968":[425],"IV.":[426],"\"Reactivation":[435],"sarcomas":[444],"inhibition":[446],"p53-HDM2":[448],"interaction.\"":[449]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}