{"id":"https://openalex.org/W2188970639","doi":null,"title":"Infusion pharmacokinetics of Lipocurc\u2122 (liposomal curcumin) and its metabolite tetrahydrocurcumin in Beagle dogs.","display_name":"Infusion pharmacokinetics of Lipocurc\u2122 (liposomal curcumin) and its metabolite tetrahydrocurcumin in Beagle dogs.","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2188970639","mag":"2188970639","pmid":"https://pubmed.ncbi.nlm.nih.gov/23060560"},"language":"en","primary_location":{"id":"pmid:23060560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110196536","display_name":"Lawrence Helson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097497","display_name":"SignPath Pharma (United States)","ror":"https://ror.org/00qdzme95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097497"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Helson","raw_affiliation_strings":["SignPath Pharma, Inc 1375 California Road, Quakertown, PA 18951, USA. lhelson@comcast.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SignPath Pharma, Inc 1375 California Road, Quakertown, PA 18951, USA. lhelson@comcast.net","institution_ids":["https://openalex.org/I4210097497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030002656","display_name":"Gordon T. Bolger","orcid":"https://orcid.org/0000-0003-0971-5064","observed_orcids":["https://orcid.org/0000-0003-0971-5064"]},"institutions":[{"id":"https://openalex.org/I4210135382","display_name":"Nucro Technics","ror":"https://ror.org/03yxrd274","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210135382"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gordon Bolger","raw_affiliation_strings":["2Nucro-Technics, Scarborough, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Nucro-Technics, Scarborough, ON, Canada","institution_ids":["https://openalex.org/I4210135382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032412684","display_name":"Muhammed A. Majeed","orcid":"https://orcid.org/0000-0002-1690-7470","observed_orcids":["https://orcid.org/0000-0002-1690-7470"]},"institutions":[{"id":"https://openalex.org/I2800373032","display_name":"Owensboro Health","ror":"https://ror.org/03re8tv59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800373032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muhammed Majeed","raw_affiliation_strings":["3Sabinsa Corporation, East Winsdor, NJ, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Sabinsa Corporation, East Winsdor, NJ, U.S.A","institution_ids":["https://openalex.org/I2800373032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003279971","display_name":"Brigitta A. Vcelar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104119","display_name":"Polymun (Austria)","ror":"https://ror.org/016rjax45","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210104119"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Brigitta Vcelar","raw_affiliation_strings":["4Polymun Scientific, Klosterneuburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Polymun Scientific, Klosterneuburg, Austria","institution_ids":["https://openalex.org/I4210104119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069401437","display_name":"Kresimir Pucaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135382","display_name":"Nucro Technics","ror":"https://ror.org/03yxrd274","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210135382"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kresimir Pucaj","raw_affiliation_strings":["2Nucro-Technics, Scarborough, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Nucro-Technics, Scarborough, ON, Canada","institution_ids":["https://openalex.org/I4210135382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030568052","display_name":"Dharmendr Matabudul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135382","display_name":"Nucro Technics","ror":"https://ror.org/03yxrd274","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4210135382"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dharmendr Matabudul","raw_affiliation_strings":["2Nucro-Technics, Scarborough, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Nucro-Technics, Scarborough, ON, Canada","institution_ids":["https://openalex.org/I4210135382"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8732,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.65548387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"10","first_page":"4365","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomal-curcumin","display_name":"liposomal curcumin","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tetrahydrocurcumin","display_name":"tetrahydrocurcumin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/infusion-rate","display_name":"infusion rate","score":0.753000020980835},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7950000166893005},{"id":"https://openalex.org/keywords/curcumin-degradation","display_name":"curcumin degradation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hepatic-clearance","display_name":"hepatic clearance","score":0.6679999828338623},{"id":"https://openalex.org/keywords/renal-excretion","display_name":"renal excretion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/plasma-half-life","display_name":"plasma half-life","score":0.9610000252723694},{"id":"https://openalex.org/keywords/biliary-excretion","display_name":"biliary excretion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5789999961853027},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8375202417373657},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.804434597492218},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7814704179763794},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6144346594810486},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5707900524139404},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.5696972012519836},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.4552153944969177},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4302116334438324},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.42782387137413025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30338865518569946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28412190079689026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2827948331832886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09846705198287964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23060560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2188970639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23060560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1965050389","https://openalex.org/W1977777929","https://openalex.org/W2013585426","https://openalex.org/W2068821865","https://openalex.org/W2074087451","https://openalex.org/W2079178816","https://openalex.org/W2083120074"],"related_works":["https://openalex.org/W2109338577","https://openalex.org/W2901454723","https://openalex.org/W2752499116","https://openalex.org/W1999529779","https://openalex.org/W2314114582","https://openalex.org/W2800482807","https://openalex.org/W2038200478","https://openalex.org/W4408571307","https://openalex.org/W2885544802","https://openalex.org/W3151914209"],"abstract_inverted_index":{"Curcumin's":[0],"instability":[1],"and":[2,17,47,58,71,77,93,100,124,137,169,176,210,223,237],"its":[3],"metabolite,":[4],"tetrahydrocurcumin":[5],"(THC)":[6],"pose":[7],"a":[8,115,118,125,171,201],"major":[9],"issue":[10],"for":[11,208],"the":[12,45,53,98,144,152,162,212],"establishment":[13],"of":[14,27,42,91,117,120,129,135,158,173],"dependable":[15],"pharmacokinetics":[16],"excretion":[18,185],"profiles.":[19],"Additional":[20],"pharmacokinetic":[21],"variances":[22],"are":[23,240],"associated":[24],"with":[25,35,64,82,188],"durations":[26],"intravenous":[28],"infusions.":[29],"We":[30],"found":[31],"that":[32,207],"stabilizing":[33],"curcumin":[34,92,109,122,136,230],"phosphoric":[36],"acid":[37],"allows":[38],"accurate":[39],"quantitative":[40],"determinations":[41],"curcuminoids":[43],"in":[44,242],"plasma":[46,156,182],"bile,":[48],"by":[49],"preventing":[50],"degradation":[51],"during":[52,97,110,141,195],"analytical":[54],"processes.":[55],"Two":[56],"male":[57],"two":[59,69,78],"females":[60],"dogs":[61,74],"were":[62,80,95,105,139,148,193],"infused":[63,81],"Lipocurc\u2122":[65,83],"10":[66,84],"mg/kg":[67,85],"over":[68,86],"hours,":[70,168],"another":[72],"four":[73],"(two":[75],"males":[76],"females)":[79],"eight":[87],"hours.":[88],"Plasma":[89],"levels":[90,104,134,147],"THC":[94,103,131,138],"determined":[96],"infusions":[99],"at":[101,180],"necropsy.":[102],"6.3-9.6-fold":[106],"higher":[107,150,181,220],"than":[108,151],"both":[111,159,174],"infusion":[112,142,146,164,214],"rates,":[113,226],"suggesting":[114],"combination":[116],"high-rate":[119],"enzymatic":[121],"metabolism":[123],"comparatively":[126],"slower":[127],"rate":[128],"blood":[130],"clearance.":[132],"When":[133],"compared":[140],"durations,":[143],"two-hour":[145,163,213],"significantly":[149],"eight-hour":[153,196],"infusion.":[154],"The":[155],"half-lives":[157],"compounds":[160],"following":[161],"ranged":[165],"from":[166],"0.4-0.7":[167],"was":[170],"consequence":[172],"hepatic":[175],"renal":[177,184],"clearance":[178,191,225],"However,":[179],"concentrations":[183],"predominated,":[186],"particularly":[187],"THC.":[189],"Enhanced":[190],"rates":[192],"noted":[194],"infusions,":[197],"which":[198],"prevented":[199],"achieving":[200],"steady":[202],"state.":[203],"These":[204],"observations":[205],"suggest":[206],"leukemias":[209],"lymphomas,":[211],"may":[215],"be":[216],"advantageous":[217],"based":[218],"upon":[219],"concentration":[221],"profiles,":[222],"unstimulated":[224],"however":[227],"data":[228,239],"on":[229],"penetration":[231],"into":[232],"circulating":[233],"hematopoietic":[234],"cancer":[235],"cells":[236],"efficacy":[238],"required":[241],"order":[243],"to":[244],"confirm":[245],"these":[246],"suggestions.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
