{"id":"https://openalex.org/W2188950002","doi":null,"title":"MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type","display_name":"MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2188950002","mag":"2188950002"},"language":"en","primary_location":{"id":"mag:2188950002","doi":null,"is_oa":false,"landing_page_url":"https://omicsonline.com/open-access/micrornas-and-endothelial-dysfunction-in-relation-to-obesity-and-type-diabetes-1747-0862-S1.011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073544291","display_name":"Silambarasan Maskomani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silambarasan Maskomani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016443153","display_name":"Arunmozhiarasi Armugam","orcid":"https://orcid.org/0000-0002-6064-1980","observed_orcids":["https://orcid.org/0000-0002-6064-1980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arunmozhiarasi Armugam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6064-1980","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076885130","display_name":"Kandiah Jeyaseelan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kandiah Jeyaseelan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15339273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":1.0},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":1.0},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/vascular-complications","display_name":"vascular complications","score":0.8840000033378601},{"id":"https://openalex.org/keywords/vascular-homeostasis","display_name":"vascular homeostasis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.7070000171661377},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mirna-dysregulation","display_name":"microRNA dysregulation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/vascular-disease-treatment","display_name":"vascular disease treatment","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.7932783365249634},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6608827710151672},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6400232315063477},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.586554765701294},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5819032192230225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44089192152023315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43935054540634155},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4337748885154724},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4226984977722168},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38475456833839417},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37332969903945923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35966479778289795},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35690951347351074},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.337216317653656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09671291708946228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08736619353294373},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188950002","doi":null,"is_oa":false,"landing_page_url":"https://omicsonline.com/open-access/micrornas-and-endothelial-dysfunction-in-relation-to-obesity-and-type-diabetes-1747-0862-S1.011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":134,"referenced_works":["https://openalex.org/W12690937","https://openalex.org/W111976367","https://openalex.org/W144423133","https://openalex.org/W1514693175","https://openalex.org/W1529592271","https://openalex.org/W1535099129","https://openalex.org/W1545606694","https://openalex.org/W1666806163","https://openalex.org/W1675830194","https://openalex.org/W1968102833","https://openalex.org/W1969294374","https://openalex.org/W1972989638","https://openalex.org/W1975258993","https://openalex.org/W1975998449","https://openalex.org/W1976555160","https://openalex.org/W1977258345","https://openalex.org/W1978337436","https://openalex.org/W1978684704","https://openalex.org/W1982811953","https://openalex.org/W1984633752","https://openalex.org/W1984731724","https://openalex.org/W1986673875","https://openalex.org/W1988376520","https://openalex.org/W1989067276","https://openalex.org/W1989433466","https://openalex.org/W1989910375","https://openalex.org/W1993966022","https://openalex.org/W1995765328","https://openalex.org/W1995902696","https://openalex.org/W1998696106","https://openalex.org/W2000509898","https://openalex.org/W2001295759","https://openalex.org/W2011992805","https://openalex.org/W2015224754","https://openalex.org/W2022575040","https://openalex.org/W2025959822","https://openalex.org/W2026570544","https://openalex.org/W2026581189","https://openalex.org/W2033124959","https://openalex.org/W2033595939","https://openalex.org/W2034413738","https://openalex.org/W2039420330","https://openalex.org/W2040191060","https://openalex.org/W2042150160","https://openalex.org/W2042742088","https://openalex.org/W2044437167","https://openalex.org/W2044586762","https://openalex.org/W2046044787","https://openalex.org/W2047254315","https://openalex.org/W2048433654","https://openalex.org/W2049113370","https://openalex.org/W2051269098","https://openalex.org/W2051430335","https://openalex.org/W2052055930","https://openalex.org/W2054233490","https://openalex.org/W2055627344","https://openalex.org/W2055844905","https://openalex.org/W2065525860","https://openalex.org/W2066670499","https://openalex.org/W2067096633","https://openalex.org/W2067514854","https://openalex.org/W2069009920","https://openalex.org/W2070207988","https://openalex.org/W2072669769","https://openalex.org/W2079245209","https://openalex.org/W2080137338","https://openalex.org/W2088329271","https://openalex.org/W2088543680","https://openalex.org/W2088648948","https://openalex.org/W2090017296","https://openalex.org/W2091108337","https://openalex.org/W2091880327","https://openalex.org/W2092535353","https://openalex.org/W2094530722","https://openalex.org/W2095580512","https://openalex.org/W2098550211","https://openalex.org/W2101835986","https://openalex.org/W2102683312","https://openalex.org/W2102939844","https://openalex.org/W2103086537","https://openalex.org/W2106776242","https://openalex.org/W2107274536","https://openalex.org/W2107631531","https://openalex.org/W2109481604","https://openalex.org/W2111867309","https://openalex.org/W2111947855","https://openalex.org/W2112849743","https://openalex.org/W2114289687","https://openalex.org/W2115206563","https://openalex.org/W2117781794","https://openalex.org/W2119786102","https://openalex.org/W2121271900","https://openalex.org/W2121796458","https://openalex.org/W2122661176","https://openalex.org/W2123137429","https://openalex.org/W2124312719","https://openalex.org/W2125290657","https://openalex.org/W2126877661","https://openalex.org/W2127131367","https://openalex.org/W2128147036","https://openalex.org/W2128674168","https://openalex.org/W2129994868","https://openalex.org/W2130330362","https://openalex.org/W2132681327","https://openalex.org/W2136209475","https://openalex.org/W2137976281","https://openalex.org/W2139128338","https://openalex.org/W2139342290","https://openalex.org/W2139728435","https://openalex.org/W2139801418","https://openalex.org/W2143787351","https://openalex.org/W2147071298","https://openalex.org/W2149098481","https://openalex.org/W2149372820","https://openalex.org/W2149413458","https://openalex.org/W2153401001","https://openalex.org/W2155912199","https://openalex.org/W2156992393","https://openalex.org/W2159807040","https://openalex.org/W2160447597","https://openalex.org/W2161068194","https://openalex.org/W2161693225","https://openalex.org/W2163199119","https://openalex.org/W2163294226","https://openalex.org/W2163376944","https://openalex.org/W2164597948","https://openalex.org/W2168670059","https://openalex.org/W2168774749","https://openalex.org/W2169328918","https://openalex.org/W2170234814","https://openalex.org/W2170952313","https://openalex.org/W2322796158","https://openalex.org/W7098392294","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W2322796158","https://openalex.org/W3084687932","https://openalex.org/W264687045","https://openalex.org/W2561450689","https://openalex.org/W7133299922","https://openalex.org/W4381248497","https://openalex.org/W3180820775","https://openalex.org/W2978451331","https://openalex.org/W2897379264","https://openalex.org/W2790949929"],"abstract_inverted_index":{"The":[0,118],"vascular":[1,46,56,116,175,226],"endothelium":[2,31],"constitutes":[3],"an":[4],"important":[5],"barrier":[6],"for":[7,54,222],"the":[8,18,21,30,34,74,82,97,104,113,127,133,146,150,180,192,198,204,208,213,223],"selective":[9],"passage":[10],"of":[11,36,99,106,115,129,140,152,163,185,194,210,215,225],"plasma":[12],"proteins,":[13],"solutes":[14],"and":[15,24,39,62,68,78,101,123,182,187,218],"fluid":[16],"from":[17,73],"blood":[19,59],"to":[20,28,44,84,148,191],"underlying":[22],"interstitium":[23],"cells.":[25],"In":[26,160],"addition":[27],"that,":[29],"also":[32,202],"regulates":[33],"production":[35],"various":[37,170],"autocrine":[38],"paracrine":[40],"factors":[41],"in":[42,103,110,169,189,212],"order":[43],"maintain":[45],"homeostasis.":[47],"Hence,":[48],"normal":[49],"endothelial":[50,87,107,124,195,216],"function":[51],"is":[52,165],"critical":[53],"proper":[55],"activity":[57],"including":[58,173],"vessel":[60],"development":[61,214],"growth":[63],"(angiogenesis),":[64],"leukocyte":[65,85],"trafficking,":[66],"coagulation":[67],"fibrinolysis.":[69],"Endothelial":[70],"dysfunction":[71,108,125,217],"results":[72],"imbalance":[75],"between":[76,120,132],"vasoconstriction":[77],"vasodilation":[79],"that":[80,155],"predispose":[81],"vasculature":[83],"adherence,":[86],"proliferation":[88],"as":[89,91],"well":[90],"thrombosis.":[92],"Several":[93],"studies":[94],"have":[95,145],"demonstrated":[96],"implication":[98],"obesity":[100,186],"diabetes":[102,122,188],"progression":[105],"which":[109],"turn":[111],"accelerates":[112],"manifestation":[114,193],"complications.":[117,176],"coexistence":[119],"obesity,":[121],"suggests":[126],"involvement":[128],"common":[130,167],"regulators":[131,142],"three":[134],"entities.":[135],"MicroRNAs":[136],"are":[137],"promising":[138],"candidates":[139],"these":[141],"since":[143],"they":[144],"ability":[147],"control":[149],"expression":[151],"multiple":[153],"genes":[154],"regulate":[156],"our":[157],"cellular":[158],"processes.":[159],"fact,":[161],"dysregulation":[162],"microRNAs":[164,211],"a":[166],"feature":[168],"human":[171],"diseases":[172],"obese/diabetes-associated":[174],"This":[177],"review":[178],"describes":[179],"direct":[181],"indirect":[183],"mechanisms":[184],"relation":[190],"dysfunction.":[196],"At":[197],"same":[199],"time,":[200],"it":[201],"summarizes":[203],"latest":[205],"insights":[206],"into":[207],"implications":[209],"discusses":[219],"their":[220],"potential":[221],"treatment":[224],"pathophysiological":[227],"conditions.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}