{"id":"https://openalex.org/W2188944400","doi":null,"title":"Reagents and methods for PET using bispecific antibody pretargeting and 68Ga-radiolabeled bivalent hapten-peptide-chelate conjugates.","display_name":"Reagents and methods for PET using bispecific antibody pretargeting and 68Ga-radiolabeled bivalent hapten-peptide-chelate conjugates.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2188944400","mag":"2188944400","pmid":"https://pubmed.ncbi.nlm.nih.gov/14734668"},"language":"en","primary_location":{"id":"pmid:14734668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14734668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Evaluation Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072370404","display_name":"Gary L. Griffiths","orcid":"https://orcid.org/0000-0002-6252-1309","observed_orcids":["https://orcid.org/0000-0002-6252-1309"]},"institutions":[{"id":"https://openalex.org/I4210126919","display_name":"Immunomedics (United States)","ror":"https://ror.org/02pf50490","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary L Griffiths","raw_affiliation_strings":["Immunomedics, Inc., Morris Plains, New Jersey. Garden State Cancer Center, Belleville, New Jersey 07950, USA. ggriffiths@immunomedics.com","Immunomedics, Inc., Morris Plains, New Jersey. Garden State Cancer Center, Belleville, New Jersey 07950, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunomedics, Inc., Morris Plains, New Jersey. Garden State Cancer Center, Belleville, New Jersey 07950, USA. ggriffiths@immunomedics.com","institution_ids":["https://openalex.org/I4210126919"]},{"raw_affiliation_string":"Immunomedics, Inc., Morris Plains, New Jersey. Garden State Cancer Center, Belleville, New Jersey 07950, USA","institution_ids":["https://openalex.org/I4210126919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109346302","display_name":"Chien\u2010Hsing Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chien-Hsing Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"William J McBride","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J McBride","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966471","display_name":"Edmund A. Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmund A Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060382419","display_name":"Agatha Sheerin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agatha Sheerin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064920620","display_name":"German R. Tejada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"German R Tejada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045775470","display_name":"Habibe Karacay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Habibe Karacay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043569662","display_name":"Robert M. Sharkey","orcid":"https://orcid.org/0000-0003-1408-0905","observed_orcids":["https://orcid.org/0000-0003-1408-0905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M Sharkey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062966348","display_name":"Ivan David Horak","orcid":"https://orcid.org/0009-0003-8726-4016","observed_orcids":["https://orcid.org/0009-0003-8726-4016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan D Horak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111565592","display_name":"Hans J. Hansen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans J Hansen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003890903","display_name":"David M. Goldenberg","orcid":"https://orcid.org/0000-0001-5539-421X","observed_orcids":["https://orcid.org/0000-0001-5539-421X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M Goldenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4476,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.94211271,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"1","first_page":"30","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gallium-68","display_name":"gallium-68","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.6639999747276306},{"id":"https://openalex.org/keywords/dota-chelator","display_name":"DOTA chelator","score":0.6940000057220459},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.8960000276565552},{"id":"https://openalex.org/keywords/68ge-68ga-generator","display_name":"68Ge/68Ga generator","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.37400001287460327},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.45399999618530273},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.34200000762939453},{"id":"https://openalex.org/keywords/gallium-67","display_name":"gallium-67","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2777836882","wikidata":"https://www.wikidata.org/wiki/Q22907915","display_name":"Pretargeting","level":5,"score":0.9847112894058228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7351769804954529},{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.702362060546875},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6692934632301331},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.6114868521690369},{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.5868454575538635},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5682782530784607},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.5604774951934814},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5405250191688538},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.5303213000297546},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.46141135692596436},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4353216886520386},{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.37693530321121216},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.375510573387146},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3552098870277405},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3301982283592224},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3072015047073364},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2725757956504822},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0907052755355835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08308574557304382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08272877335548401},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0798148512840271},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006241","descriptor_name":"Haptens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14734668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14734668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Evaluation Study"},{"id":"mag:2188944400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14734668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1490098252","https://openalex.org/W1497075656","https://openalex.org/W1559715985","https://openalex.org/W1573430780","https://openalex.org/W1573871285","https://openalex.org/W1822661802","https://openalex.org/W1833143896","https://openalex.org/W1848594274","https://openalex.org/W1856650436","https://openalex.org/W1885445898","https://openalex.org/W1952970584","https://openalex.org/W1973796908","https://openalex.org/W1978689317","https://openalex.org/W1985061998","https://openalex.org/W1996820981","https://openalex.org/W2002934363","https://openalex.org/W2005659004","https://openalex.org/W2015401584","https://openalex.org/W2019496098","https://openalex.org/W2025071011","https://openalex.org/W2026305248","https://openalex.org/W2026760562","https://openalex.org/W2035619243","https://openalex.org/W2042557161","https://openalex.org/W2045378189","https://openalex.org/W2046748401","https://openalex.org/W2048748786","https://openalex.org/W2057891684","https://openalex.org/W2058970445","https://openalex.org/W2064082799","https://openalex.org/W2072731349","https://openalex.org/W2074729561","https://openalex.org/W2089740871","https://openalex.org/W2123192469","https://openalex.org/W2148239074","https://openalex.org/W2184839900","https://openalex.org/W2185003188","https://openalex.org/W2268314510","https://openalex.org/W2287865666"],"related_works":["https://openalex.org/W7095524959","https://openalex.org/W2115287378","https://openalex.org/W2293039128","https://openalex.org/W1573871285","https://openalex.org/W2058970445","https://openalex.org/W7161627263","https://openalex.org/W2287865666","https://openalex.org/W2052933378","https://openalex.org/W2064082799","https://openalex.org/W2189193521"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,43,55,275,355],"aim":[2],"of":[3,32,38,120,176,229,266,271,317,332,376],"this":[4,146],"work":[5],"was":[6,89,278],"to":[7,91,170,179,281,312],"develop":[8],"reagents":[9],"and":[10,36,68,131,157,162,211,293,329,337,344,347,349,351,364],"methods":[11,67,367],"potentially":[12],"useful":[13,191],"in":[14,18,107,115,140,251,264,286,381],"PET,":[15],"using":[16,64,72,321],"(68)Ga":[17,96,161,194,214,231,273],"a":[19,50,100,116,132,190,259,382],"2-step":[20],"pretargeting":[21],"protocol.":[22],"METHODS:":[23],"We":[24,148],"prepared":[25,58,144],"bispecific":[26,70,135,296],"antibodies":[27],"(bsAbs)":[28],"for":[29,111,145,193,261,302,307,325,374],"disease-specific":[30],"targeting":[31,113,379],"carcinoembryonic":[33],"antigen-positive":[34],"cells":[35],"recognition":[37],"later-administered":[39],"bivalent":[40,151,202],"hapten-peptide":[41,203],"conjugates.":[42],"secondary":[44],"antibody":[45],"arm":[46],"(antibody":[47],"679)":[48],"recognizes":[49],"histaminyl-succinyl-glycine":[51],"(HSG)":[52],"structural":[53],"subunit.":[54],"bsAbs":[56],"were":[57,105,143,305,342],"as":[59,69,189,235,258],"Fab'":[60,62],"x":[61,128],"conjugates":[63],"chemical":[65,292],"cross-linking":[66],"diabodies":[71],"recombinant":[73],"DNA":[74],"technologies.":[75],"A":[76,124],"HSG-bivalent":[77],"hapten":[78],"conjugate":[79],"bearing":[80],"the":[81,150,199,213,216,220,230,244,247,267,272,291,294,322,361,365],"macrocyclic":[82],"ring":[83],"chelating":[84],"agent":[85],"1,4,7,10-tetraazacyclododecane-N,N',N\",N\"'-tetraacetic":[86],"acid":[87],"(DOTA)":[88],"designed":[90],"be":[92],"readily":[93],"radiolabeled":[94],"with":[95,160,204,246,289,360],"taken":[97],"directly":[98,218],"from":[99,166,215],"(68)Ge/(68)Ga":[101],"generator":[102,217],"system.":[103],"Reagents":[104],"tested":[106],"vitro":[108],"and,":[109],"then,":[110],"their":[112],"properties":[114],"preclinical":[117],"animal":[118],"model":[119],"human":[121,282],"cancer.":[122],"RESULTS:":[123],"chemically":[125],"cross-linked":[126],"hMN-14":[127],"679":[129,248],"F(ab')(2)":[130],"fully":[133],"humanized":[134],"diabody":[136,295,324],"construct":[137],"(BS1.5H),":[138],"expressed":[139],"Escherichia":[141],"coli,":[142],"work.":[147],"synthesized":[149],"peptide":[152,221],"termed":[153],"IMP":[154,200,233],"241":[155,201,257,277,334],"[DOTA-Phe-Lys(HSG)-D-Tyr-Lys(HSG)-NH(2)]":[156],"labeled":[158],"it":[159],"(67)Ga":[163,303],"at":[164,185,208,310,335],"temperatures":[165],"45":[167],"degrees":[168,172,187],"C":[169,188],"100":[171],"C,":[173],"over":[174],"times":[175],"15":[177,183],"min":[178,184],"1":[180,311,336],"h,":[181],"establishing":[182],"95":[186],"condition":[192],"labeling.":[195],"When":[196,320],"we":[197,223,254,368],"formulated":[198],"ammonium":[205],"acetate":[206],"buffer":[207],"pH":[209],"4-5":[210],"eluted":[212],"into":[219,232],"solution,":[222],"achieved":[224],"an":[225],"almost":[226],"quantitative":[227],"incorporation":[228],"241,":[234,263],"analyzed":[236],"by":[237],"size-exclusion":[238],"high-performance":[239],"liquid":[240],"chromatography,":[241],"after":[242,315,340],"mixing":[243],"complex":[245],"antibody.":[249],"For":[250],"vivo":[252],"studies":[253],"used":[255],"(67)Ga-IMP":[256,276,318,333],"surrogate":[260],"(68)Ga-IMP":[262],"view":[265],"short,":[268],"68-min":[269],"half-life":[270],"nuclide.":[274],"successfully":[279],"pretargeted":[280],"colon":[283],"tumor":[284],"xenografts":[285],"athymic":[287],"mice":[288],"both":[290],"proteins.":[297],"High":[298],"tumor-to-normal":[299],"tissue":[300],"ratios":[301,331],"uptake":[304],"found":[306],"all":[308],"tissues":[309],"6":[313],"h":[314,339],"injection":[316,341],"241.":[319],"BS1.5H":[323],"pretargeting,":[326],"tumor-to-blood,":[327],"tumor-to-liver,":[328],"tumor-to-lung":[330],"3":[338],"41:1":[343],"137:1,":[345],"51:1":[346],"106:1,":[348],"16:1":[350],"46:1,":[352],"respectively.":[353],"CONCLUSION:":[354],"general":[356],"approach":[357],"described,":[358],"along":[359],"new":[362],"compositions":[363],"labeling":[366],"have":[369],"developed,":[370],"may":[371],"eventually":[372],"allow":[373],"use":[375],"(68)Ga-labeled":[377],"specific":[378],"agents":[380],"routine":[383],"clinical":[384],"PET":[385],"application.":[386]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}