{"id":"https://openalex.org/W2188835441","doi":null,"title":"Lycopene Enhances Docetaxel's Effect in Castration-Resistant","display_name":"Lycopene Enhances Docetaxel's Effect in Castration-Resistant","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2188835441","mag":"2188835441"},"language":"en","primary_location":{"id":"mag:2188835441","doi":null,"is_oa":false,"landing_page_url":"http://www.nutraxin.com.tr/pdf/SolanumLycopersicum/Solanum_02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115601335","display_name":"Yaxiong Tang","orcid":"https://orcid.org/0000-0003-1103-7872","observed_orcids":["https://orcid.org/0000-0003-1103-7872","https://orcid.org/0009-0000-4374-9642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaxiong Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1103-7872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020847537","display_name":"Basmina Parmakhtiar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basmina Parmakhtiar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064775495","display_name":"Anne R. Simoneau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne R. Simoneau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102786181","display_name":"Jun Xie","orcid":"https://orcid.org/0000-0003-4122-5129","observed_orcids":["https://orcid.org/0000-0003-4122-5129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Xie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4122-5129","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061918246","display_name":"John P. Fruehauf","orcid":"https://orcid.org/0000-0002-9447-9440","observed_orcids":["https://orcid.org/0000-0002-9447-9440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Fruehauf","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9447-9440","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517019","display_name":"Michael B. Lilly","orcid":"https://orcid.org/0000-0001-9000-3608","observed_orcids":["https://orcid.org/0000-0001-9000-3608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael B. Lilly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036496290","display_name":"Xiaolin Zi","orcid":"https://orcid.org/0000-0002-5312-7158","observed_orcids":["https://orcid.org/0000-0002-5312-7158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaolin Zi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5312-7158","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2451837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lycopene","display_name":"lycopene","score":0.996999979019165},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.8209999799728394},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/akt-kinase","display_name":"Akt kinase","score":0.7900000214576721},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.859000027179718},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9459570646286011},{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.9053635597229004},{"id":"https://openalex.org/C2780022147","wikidata":"https://www.wikidata.org/wiki/Q208130","display_name":"Lycopene","level":3,"score":0.8247132301330566},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.691726565361023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5970215797424316},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.5468213558197021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46980032324790955},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44647303223609924},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.3970024585723877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3899478018283844},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3337544798851013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3318507671356201},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.21671992540359497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13167256116867065}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188835441","doi":null,"is_oa":false,"landing_page_url":"http://www.nutraxin.com.tr/pdf/SolanumLycopersicum/Solanum_02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1496974689","https://openalex.org/W1558209803","https://openalex.org/W1607134312","https://openalex.org/W1675602016","https://openalex.org/W1967833981","https://openalex.org/W1987412338","https://openalex.org/W1990134102","https://openalex.org/W2005658600","https://openalex.org/W2007681149","https://openalex.org/W2011923225","https://openalex.org/W2018481414","https://openalex.org/W2024790399","https://openalex.org/W2025865695","https://openalex.org/W2030891282","https://openalex.org/W2041620567","https://openalex.org/W2045873744","https://openalex.org/W2050948499","https://openalex.org/W2063547455","https://openalex.org/W2064697364","https://openalex.org/W2079975206","https://openalex.org/W2098544382","https://openalex.org/W2100970263","https://openalex.org/W2104589766","https://openalex.org/W2104762821","https://openalex.org/W2109526314","https://openalex.org/W2112226957","https://openalex.org/W2114883533","https://openalex.org/W2117767912","https://openalex.org/W2118906222","https://openalex.org/W2123493843","https://openalex.org/W2124245112","https://openalex.org/W2126677162","https://openalex.org/W2132299300","https://openalex.org/W2133433434","https://openalex.org/W2133777904","https://openalex.org/W2142054229","https://openalex.org/W2143942942","https://openalex.org/W2145777186","https://openalex.org/W2147909933","https://openalex.org/W2156502916","https://openalex.org/W2156585356","https://openalex.org/W2157210567","https://openalex.org/W2159753688","https://openalex.org/W2163818055","https://openalex.org/W2164660906","https://openalex.org/W2169467636","https://openalex.org/W2170161072","https://openalex.org/W2196576614","https://openalex.org/W4298290178"],"related_works":["https://openalex.org/W1496974689","https://openalex.org/W2502702344","https://openalex.org/W4393097996","https://openalex.org/W3134090473","https://openalex.org/W3089863507","https://openalex.org/W3203203743","https://openalex.org/W1966572978","https://openalex.org/W3043280207","https://openalex.org/W1998231892","https://openalex.org/W1646534842"],"abstract_inverted_index":{"Docetaxel":[0],"is":[1,41],"currently":[2],"the":[3,8,48,82,144,165],"most":[4,193],"effective":[5],"drug":[6],"for":[7,183],"treatment":[9,80],"of":[10,23,60,85,148,154,167,178],"castration-resistant":[11],"prostate":[12,34],"cancer":[13,35],"(CRPC),":[14],"but":[15],"it":[16],"only":[17],"extends":[18],"life":[19],"by":[20,142,162,171],"an":[21,27],"average":[22],"2":[24],"months.":[25],"Lycopene,":[26],"antioxidant":[28],"phytochemical,":[29],"has":[30],"antitumor":[31,123,169],"activity":[32,157],"against":[33],"(PCa)":[36],"in":[37,54,122],"several":[38],"models":[39],"and":[40,52,141,146,158,180],"generally":[42],"safe.":[43],"We":[44],"present":[45],"data":[46],"on":[47,62,89,97],"interaction":[49],"between":[50],"docetaxel":[51,86,112,131,181],"lycopene":[53,61,79,114,172,179],"CRPC":[55,184,186],"models.":[56],"The":[57],"growth-inhibitory":[58,83],"effect":[59,84],"PCa":[63,99],"cell":[64,100],"lines":[65,101],"was":[66],"positively":[67],"associated":[68],"with":[69,92,102,118,130,188],"insulin-like":[70],"growth":[71],"factor":[72],"I":[73],"receptor":[74],"(IGF-IR)":[75],"levels.":[76],"In":[77,106],"addition,":[78],"enhanced":[81],"more":[87],"effectively":[88],"DU145":[90,108],"cells":[91],"IGF-IR":[93,103,135],"high":[94],"expression":[95,145],"than":[96],"those":[98],"low":[104],"expression.":[105],"a":[107,119],"xenograft":[109],"tumor":[110,116],"model,":[111],"plus":[113],"caused":[115],"regression,":[117],"38%":[120],"increase":[121],"efficacy":[124,170],"(P":[125],"=":[126],".047)":[127],"when":[128],"compared":[129],"alone.":[132],"Lycopene":[133],"inhibited":[134],"activation":[136],"through":[137],"inhibiting":[138],"IGF-I":[139],"stimulation":[140],"increasing":[143],"secretion":[147],"IGF-BP3.":[149],"Downstream":[150],"effects":[151],"include":[152],"inhibition":[153],"AKT":[155],"kinase":[156],"survivin":[159],"expression,":[160],"followed":[161],"apoptosis.":[163],"Together,":[164],"enhancement":[166],"docetaxel\u2019s":[168],"supplementation":[173],"justifies":[174],"further":[175],"clinical":[176],"investigation":[177],"combination":[182],"patients.":[185],"patients":[187],"IGF-IR\u2013overexpressing":[189],"tumors":[190],"may":[191],"be":[192],"likely":[194],"to":[195],"benefit":[196],"from":[197],"this":[198],"combination.":[199]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}