{"id":"https://openalex.org/W2188807336","doi":null,"title":"Persisting anti-phage CRISPR immunity in multiple human gut microbiomes","display_name":"Persisting anti-phage CRISPR immunity in multiple human gut microbiomes","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2188807336","mag":"2188807336"},"language":"en","primary_location":{"id":"mag:2188807336","doi":null,"is_oa":false,"landing_page_url":"https://www.weizmann.ac.il/molgen/Sorek/files/publications/Mick_RNA_Biology_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017147813","display_name":"Eran Mick","orcid":"https://orcid.org/0000-0002-7299-808X","observed_orcids":["https://orcid.org/0000-0002-7299-808X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eran Mick","raw_affiliation_strings":["Weizmann institute of science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weizmann institute of science;","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067804324","display_name":"Adi Stern","orcid":"https://orcid.org/0000-0002-2919-3542","observed_orcids":["https://orcid.org/0000-0002-2919-3542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adi Stern","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2919-3542","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024718393","display_name":"Rotem Sorek","orcid":"https://orcid.org/0000-0002-3872-4982","observed_orcids":["https://orcid.org/0000-0002-3872-4982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rotem Sorek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3872-4982","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13040541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas-systems","display_name":"CRISPR-Cas","score":0.8560000061988831},{"id":"https://openalex.org/keywords/phage-bacteria-interactions","display_name":"phage-bacteria interactions","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8370000123977661},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.6129999756813049},{"id":"https://openalex.org/keywords/temperate-phages","display_name":"temperate phages","score":0.902999997138977},{"id":"https://openalex.org/keywords/phage-resistance","display_name":"phage resistance","score":0.5590000152587891},{"id":"https://openalex.org/keywords/metagenomics","display_name":"metagenomics","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.9556612968444824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7706893682479858},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6806657314300537},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5675471425056458},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5047682523727417},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.46855077147483826},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4632253646850586},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4606386125087738},{"id":"https://openalex.org/C48292096","wikidata":"https://www.wikidata.org/wiki/Q6710264","display_name":"Lysogen","level":5,"score":0.4538094997406006},{"id":"https://openalex.org/C136199206","wikidata":"https://www.wikidata.org/wiki/Q1148110","display_name":"Lysogenic cycle","level":5,"score":0.44683343172073364},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.446024090051651},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.43922722339630127},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4365094304084778},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.34733128547668457},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26470011472702026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2627422511577606},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.06107404828071594}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188807336","doi":null,"is_oa":false,"landing_page_url":"https://www.weizmann.ac.il/molgen/Sorek/files/publications/Mick_RNA_Biology_2013.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1514768507","https://openalex.org/W1563631267","https://openalex.org/W1577973179","https://openalex.org/W1588428936","https://openalex.org/W1597185777","https://openalex.org/W1965404910","https://openalex.org/W1969479889","https://openalex.org/W1970515032","https://openalex.org/W1971115321","https://openalex.org/W1972708645","https://openalex.org/W1986171241","https://openalex.org/W1988244832","https://openalex.org/W1988885405","https://openalex.org/W1991604124","https://openalex.org/W1998661584","https://openalex.org/W2000545911","https://openalex.org/W2007153971","https://openalex.org/W2008790072","https://openalex.org/W2013018092","https://openalex.org/W2017721099","https://openalex.org/W2022480099","https://openalex.org/W2025828332","https://openalex.org/W2027591298","https://openalex.org/W2034048377","https://openalex.org/W2040263545","https://openalex.org/W2043083543","https://openalex.org/W2047032063","https://openalex.org/W2057092463","https://openalex.org/W2059901968","https://openalex.org/W2062280978","https://openalex.org/W2071841602","https://openalex.org/W2076184415","https://openalex.org/W2077190448","https://openalex.org/W2078115022","https://openalex.org/W2085436536","https://openalex.org/W2085992785","https://openalex.org/W2087712940","https://openalex.org/W2088209062","https://openalex.org/W2088817509","https://openalex.org/W2097146199","https://openalex.org/W2101727152","https://openalex.org/W2104910883","https://openalex.org/W2112261922","https://openalex.org/W2112295554","https://openalex.org/W2112671289","https://openalex.org/W2113601822","https://openalex.org/W2119585200","https://openalex.org/W2124937554","https://openalex.org/W2131186249","https://openalex.org/W2135598273","https://openalex.org/W2136345927","https://openalex.org/W2139884694","https://openalex.org/W2144241990","https://openalex.org/W2145537580","https://openalex.org/W2148630429","https://openalex.org/W2149751339","https://openalex.org/W2151259830","https://openalex.org/W2151372451","https://openalex.org/W2154186763","https://openalex.org/W2154918118","https://openalex.org/W2159808296","https://openalex.org/W2161251845","https://openalex.org/W2162088497","https://openalex.org/W2165011752","https://openalex.org/W2166192874","https://openalex.org/W2168933209","https://openalex.org/W2169244146","https://openalex.org/W2169330513","https://openalex.org/W2169999664","https://openalex.org/W2170255645","https://openalex.org/W2171152411"],"related_works":["https://openalex.org/W1973248758","https://openalex.org/W4400800816","https://openalex.org/W4405763963","https://openalex.org/W3034504152","https://openalex.org/W2972142394","https://openalex.org/W2148630429","https://openalex.org/W2073751868","https://openalex.org/W7213972577","https://openalex.org/W2802066476","https://openalex.org/W7095507590"],"abstract_inverted_index":{"The":[0],"CRISPR":[1,92],"(clustered":[2],"regularly":[3],"interspaced":[4],"short":[5],"palindromic":[6],"repeats)/Cas":[7],"(CRISPR-associated)":[8],"system":[9,45],"of":[10,17,29,38,58,111,116,135,149,151],"bacteria":[11,72,123],"and":[12,94,124,138,146],"archaea":[13],"constitutes":[14],"a":[15,36,98],"mechanism":[16],"acquired":[18],"adaptive":[19],"immunity":[20],"against":[21],"phages,":[22,126],"which":[23,127],"is":[24],"based":[25],"on":[26,101,142],"genome-encoded":[27],"markers":[28],"previously":[30],"infecting":[31],"phage":[32,39],"sequences":[33],"(\u201cspacers\u201d).":[34],"As":[35],"repository":[37],"sequences,":[40],"these":[41],"spacers":[42,137],"make":[43],"the":[44,62,102,108,114,120,133,143],"particularly":[46],"suitable":[47],"for":[48,84,113],"elucidating":[49],"phage-bacteria":[50,95],"interactions":[51],"in":[52,73,118],"metagenomic":[53,56],"studies.":[54],"Recent":[55],"analyses":[57],"CRISPRs":[59],"associated":[60],"with":[61,97],"human":[63,103],"microbiome":[64],"intriguingly":[65],"revealed":[66],"conserved":[67],"\u201cmemory":[68],"spacers\u201d":[69],"shared":[70],"by":[71,88],"multiple":[74],"unrelated,":[75],"geographically":[76],"separated":[77],"individuals.":[78],"Here,":[79],"we":[80],"discuss":[81],"possible":[82],"avenues":[83],"explaining":[85],"this":[86],"phenomenon":[87],"integrating":[89],"insights":[90],"from":[91],"biology":[93],"ecology,":[96],"special":[99],"focus":[100],"gut.":[104],"We":[105],"further":[106],"explore":[107],"growing":[109],"body":[110],"evidence":[112],"role":[115],"CRISPR/Cas":[117],"regulating":[119],"interplay":[121],"between":[122],"lysogenic":[125],"may":[128],"be":[129],"intimately":[130],"related":[131],"to":[132],"presence":[134],"memory":[136],"sheds":[139],"new":[140],"light":[141],"multifaceted":[144],"biological":[145],"ecological":[147],"modes":[148],"action":[150],"CRISPR/Cas.":[152]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}