{"id":"https://openalex.org/W2188796122","doi":null,"title":"The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.","display_name":"The retinal phenotype of Grk1-/- is compromised by a Crb1 rd8 mutation.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2188796122","mag":"2188796122","pmid":"https://pubmed.ncbi.nlm.nih.gov/26664249","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663191"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4663191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076719557","display_name":"Joseph S. Pak","orcid":"https://orcid.org/0000-0003-2004-9015","observed_orcids":["https://orcid.org/0000-0003-2004-9015"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph S Pak","raw_affiliation_strings":["Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100630683","display_name":"Eun-Jin Lee","orcid":"https://orcid.org/0000-0001-7010-6132","observed_orcids":["https://orcid.org/0000-0001-7010-6132"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun-Jin Lee","raw_affiliation_strings":["Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA ; Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering, CA","University of Southern California, Los Angeles, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA ; Department of Biomedical Engineering, University of Southern California Viterbi School of Engineering, CA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"University of Southern California, Los Angeles, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085425400","display_name":"Cheryl Mae Craft","orcid":"https://orcid.org/0000-0002-5219-3444","observed_orcids":["https://orcid.org/0000-0002-5219-3444"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Mae Craft","raw_affiliation_strings":["Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary D. Allen Laboratory for Vision Research, USC Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, CA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.5984,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.67157216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"21","issue":null,"first_page":"1281","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.8450000286102295},{"id":"https://openalex.org/keywords/external-limiting-membrane","display_name":"external limiting membrane","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8859999775886536},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/photoreceptor-apoptosis","display_name":"photoreceptor apoptosis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/knockout-mouse-models","display_name":"knockout mouse models","score":0.5989999771118164},{"id":"https://openalex.org/keywords/light-exposure","display_name":"light exposure","score":0.46799999475479126},{"id":"https://openalex.org/keywords/retinal-morphology","display_name":"retinal morphology","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7468031644821167},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.6961727738380432},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.5980114340782166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5332308411598206},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5037855505943298},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4437934458255768},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4274539053440094},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.38603854179382324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17689061164855957},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1640366017818451},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051606","descriptor_name":"G-Protein-Coupled Receptor Kinase 1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051606","descriptor_name":"G-Protein-Coupled Receptor Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062826","descriptor_name":"Zonula Occludens-1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4663191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:3650820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663191","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26664249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26664249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"mag:2188796122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26664249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4663191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4663191/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1396024002","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY003040","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6881143080","display_name":"Mechanisms of Cone Pigment Deactivation","funder_award_id":"R01EY015851","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2188796122.pdf","grobid_xml":"https://content.openalex.org/works/W2188796122.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W38390325","https://openalex.org/W76145344","https://openalex.org/W1481967758","https://openalex.org/W1533788848","https://openalex.org/W1574956333","https://openalex.org/W1601380713","https://openalex.org/W1973834502","https://openalex.org/W1977972547","https://openalex.org/W1980882009","https://openalex.org/W1984543781","https://openalex.org/W1988916936","https://openalex.org/W1989040340","https://openalex.org/W1994626566","https://openalex.org/W1997660876","https://openalex.org/W1999179844","https://openalex.org/W2000718430","https://openalex.org/W2001644882","https://openalex.org/W2005501593","https://openalex.org/W2005834906","https://openalex.org/W2013596647","https://openalex.org/W2016537683","https://openalex.org/W2023630351","https://openalex.org/W2025692747","https://openalex.org/W2027966442","https://openalex.org/W2029336069","https://openalex.org/W2029505206","https://openalex.org/W2030350058","https://openalex.org/W2038890593","https://openalex.org/W2041281312","https://openalex.org/W2045805322","https://openalex.org/W2065030928","https://openalex.org/W2067863814","https://openalex.org/W2069903330","https://openalex.org/W2076644311","https://openalex.org/W2076813807","https://openalex.org/W2083462984","https://openalex.org/W2092674368","https://openalex.org/W2100612658","https://openalex.org/W2101192001","https://openalex.org/W2102165670","https://openalex.org/W2102267006","https://openalex.org/W2104088479","https://openalex.org/W2104301336","https://openalex.org/W2108188137","https://openalex.org/W2109276098","https://openalex.org/W2110864371","https://openalex.org/W2114765964","https://openalex.org/W2115402550","https://openalex.org/W2121269254","https://openalex.org/W2122062715","https://openalex.org/W2123145135","https://openalex.org/W2123436746","https://openalex.org/W2126259711","https://openalex.org/W2128248687","https://openalex.org/W2132701025","https://openalex.org/W2133300924","https://openalex.org/W2138387337","https://openalex.org/W2139850065","https://openalex.org/W2150132566","https://openalex.org/W2154985199","https://openalex.org/W2155349225","https://openalex.org/W2159582742","https://openalex.org/W2163210334","https://openalex.org/W2167058119"],"related_works":["https://openalex.org/W7098207355","https://openalex.org/W2150132566","https://openalex.org/W2041628488","https://openalex.org/W38390325","https://openalex.org/W2286056041","https://openalex.org/W4282939440","https://openalex.org/W2070255436","https://openalex.org/W2102267006","https://openalex.org/W2109802152","https://openalex.org/W2108701018"],"abstract_inverted_index":{"PURPOSE:":[0],"Well-established":[1],"laboratory":[2],"mouse":[3,12,437],"lines":[4],"are":[5,20],"important":[6],"in":[7,43,58,102,166,233,244,250,269,314,318,366,388,400,418],"creating":[8],"genetically":[9],"engineered":[10],"knockout":[11,438],"models;":[13],"however,":[14],"these":[15,29],"routinely":[16],"used":[17,33],"inbred":[18],"strains":[19,128],"prone":[21],"to":[22,38,75,107,179,197,214,306],"spontaneous":[23],"and":[24,73,134,147,156,164,176,236,240,272,276,284,290,322,335,340,349,370,376,391,439],"deleterious":[25],"mutations.":[26],"One":[27],"of":[28,174,202,221,227,247,338,382,434,445],"strains,":[30],"the":[31,44,63,82,94,122,194,199,222,228,234,245,248,251,267,270,282,296,302,319,328,346,367,389,401,419,427,432,446],"commonly":[32],"C57BL/6N":[34],"(B6N),":[35],"was":[36,79,114,212,364,397],"discovered":[37],"carry":[39],"a":[40,54,138,241,263,311,341,435],"point":[41],"mutation":[42,69],"Crumbs":[45],"homolog":[46],"1":[47,86,170,334,354,375],"(Crb1(rd8)":[48],")":[49],"gene,":[50],"which":[51,90],"codes":[52],"for":[53,154,183,189,293],"developmental":[55],"protein":[56,361],"involved":[57],"tight":[59],"junction":[60],"formation":[61],"at":[62,266,295,298,333,353,374,407],"outer":[64,229],"limiting":[65],"membrane":[66],"(OLM).":[67],"This":[68,423],"disrupts":[70],"photoreceptor":[71,216,315],"polarity":[72],"leads":[74],"retinal":[76,195,223],"degeneration.":[77],"It":[78],"hypothesized":[80],"that":[81,426],"G-protein":[83],"receptor":[84],"kinase":[85],"knockouts":[87],"(Grk1(-/-)":[88,140,145],"),":[89],"were":[91,130,148,162,304,386],"based":[92],"on":[93,136,193],"B6N":[95,143,235,283,331,390,412,428],"strain,":[96],"would":[97],"exhibit":[98],"abnormal":[99,416],"morphological":[100,200],"phenotypes":[101,417],"their":[103],"offspring":[104],"not":[105,398],"related":[106],"GRK1's":[108],"major":[109],"phosphorylation":[110],"function.":[111],"The":[112,126,160,219,256,411],"hypothesis":[113],"tested":[115,129],"by":[116,187],"examining":[117],"Grk1(-/-)":[118,135,155,237,253,277,285,320,323,347,350,368,371,392,404,420],"with":[119,150],"or":[120,142,171,330,403],"without":[121],"Crb1(rd8)":[123],"mutation.":[124,448],"METHODS:":[125],"mice":[127,161,239,303],"C57BL/6J":[131],"(B6J),":[132],"B6N,":[133],"either":[137,327,408],"B6J":[139,275,329,402],"(;B6J))":[141],"background":[144,414,429],"(;B6N))":[146],"verified":[149],"PCR":[151],"genotype":[152],"analysis":[153,192,309],"Crb":[157],"(rd8)":[158],".":[159],"bred":[163],"raised":[165],"complete":[167],"darkness":[168],"until":[169],"3":[172,336,377],"months":[173,337],"age":[175,339],"then":[177],"exposed":[178,305],"1,000":[180],"lux":[181],"light":[182,203],"24":[184],"h,":[185],"followed":[186],"processing":[188],"immunohistochemistry":[190],"(IHC)":[191],"structure":[196],"investigate":[198],"effects":[201],"exposure.":[204],"Terminal":[205],"deoxynucleotidyl":[206],"transferase-mediated":[207],"dUTP":[208],"nick-end":[209],"labeling":[210],"(TUNEL)":[211],"performed":[213],"detect":[215],"apoptosis.":[217],"RESULTS:":[218],"microanatomy":[220],"sections":[224],"revealed":[225],"disorganization":[226],"nuclear":[230],"layer":[231],"(ONL)":[232],"(;B6N)":[238,254,286,324,351,372,393,421],"significant":[242,312,343],"decrease":[243],"thickness":[246],"ONL":[249],"3-month-old":[252,273],"mice.":[255,279],"adherens-junction-associated":[257],"protein,":[258],"Zona":[259],"occludens-1":[260],"(ZO-1),":[261],"formed":[262],"continuous":[264],"line":[265],"OLM":[268,297],"1-":[271],"control":[274],"(;B6J)":[278,321,348,369,405],"In":[280,356],"contrast,":[281],"retinas":[287,325,332,352,373,406],"showed":[288,310],"discontinuous":[289],"fragmented":[291],"staining":[292],"ZO-1":[294],"both":[299],"ages.":[300],"After":[301],"light,":[307],"TUNEL":[308],"increase":[313],"cell":[316],"death":[317],"versus":[326],"small":[342],"difference":[344],"between":[345],"month.":[355],"addition,":[357],"glial":[358],"fibrillary":[359],"acidic":[360],"(GFAP)":[362],"expression":[363],"enhanced":[365],"months.":[378],"Occasional":[379],"sprouting":[380,396],"processes":[381],"rod":[383],"bipolar":[384],"cells":[385],"detected":[387,399],"retinas,":[394],"but":[395],"age.":[409],"CONCLUSIONS:":[410],"strain":[413],"exhibited":[415],"retina.":[422],"study":[424],"demonstrates":[425],"can":[430],"influence":[431],"phenotype":[433],"genetic":[436],"introduces":[440],"potential":[441],"visual":[442],"functional":[443],"consequences":[444],"Crb1":[447]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}