{"id":"https://openalex.org/W2188775291","doi":null,"title":"MOLECULAR DOCKING ANALYSIS OF HUMAN TRANSFERRIN AND LACTOFERRIN BINDING PROTEINS OF NEISSERIA MENINGITIDIS WITH 5 HYDROXY 1-4 NAPHTHOQINONE.","display_name":"MOLECULAR DOCKING ANALYSIS OF HUMAN TRANSFERRIN AND LACTOFERRIN BINDING PROTEINS OF NEISSERIA MENINGITIDIS WITH 5 HYDROXY 1-4 NAPHTHOQINONE.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2188775291","mag":"2188775291"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.405.7030","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.405.7030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"http://www.ijpbs.net/cms/php/upload/2827_pdf.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057100840","display_name":"Tripti Sharma","orcid":"https://orcid.org/0000-0003-1799-1157","observed_orcids":["https://orcid.org/0000-0003-1799-1157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tripti Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1799-1157","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Piyush Joshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piyush Joshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.07800000160932541,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neisseria-meningitidis","display_name":"Neisseria meningitidis","score":1.0},{"id":"https://openalex.org/keywords/bacterial-meningitis","display_name":"bacterial meningitis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/transferrin-binding-protein-b","display_name":"TbpB","score":0.9940000176429749},{"id":"https://openalex.org/keywords/juglone","display_name":"juglone","score":0.9950000047683716},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.9290552139282227},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.879997968673706},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.7910098433494568},{"id":"https://openalex.org/C2777954195","wikidata":"https://www.wikidata.org/wiki/Q132209","display_name":"Neisseria","level":3,"score":0.6357592344284058},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5603830218315125},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5433564186096191},{"id":"https://openalex.org/C2779369046","wikidata":"https://www.wikidata.org/wiki/Q6072234","display_name":"Iron-binding proteins","level":3,"score":0.5345247387886047},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.505535364151001},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4396193027496338},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.4262126684188843},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4132983684539795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3875368535518646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3506929874420166},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2456619143486023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1550513505935669},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09598410129547119},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08333820104598999},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.405.7030","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.405.7030","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"http://www.ijpbs.net/cms/php/upload/2827_pdf.pdf","raw_type":"text"},{"id":"mag:2188775291","doi":null,"is_oa":false,"landing_page_url":"http://www.ijpbs.net/cms/php/upload/2827_pdf.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764788474","display_name":"International Journal of Pharma and Bio Sciences","issn_l":"0975-6299","issn":["0975-6299"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697007","host_organization_name":"Ubitech Solutions","host_organization_lineage":["https://openalex.org/P4322697007"],"host_organization_lineage_names":["Ubitech Solutions"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharma and Bio Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1611987859","https://openalex.org/W1835026157","https://openalex.org/W1845448145","https://openalex.org/W1895178838","https://openalex.org/W1968743761","https://openalex.org/W1993865754","https://openalex.org/W1999550122","https://openalex.org/W2002207439","https://openalex.org/W2010825129","https://openalex.org/W2024331611","https://openalex.org/W2027408247","https://openalex.org/W2032993680","https://openalex.org/W2035814555","https://openalex.org/W2040662204","https://openalex.org/W2050066770","https://openalex.org/W2079707671","https://openalex.org/W2081802177","https://openalex.org/W2094621349","https://openalex.org/W2105898520","https://openalex.org/W2120054497","https://openalex.org/W2128131593","https://openalex.org/W2138927473","https://openalex.org/W2139739499","https://openalex.org/W2144214053","https://openalex.org/W2162481058","https://openalex.org/W2166188930","https://openalex.org/W2169264606","https://openalex.org/W2401061375"],"related_works":["https://openalex.org/W2252766295","https://openalex.org/W7096166256","https://openalex.org/W2106360237","https://openalex.org/W3198765882","https://openalex.org/W2129681064","https://openalex.org/W2139532260","https://openalex.org/W2138586809","https://openalex.org/W2054112570","https://openalex.org/W2111873899","https://openalex.org/W2094228301"],"abstract_inverted_index":{"Neisseria":[0,53,102],"meningitidis":[1,54],"is":[2,32,45,56,70],"the":[3,16,37,46,50,109,187],"principal":[4],"cause":[5],"of":[6,18,29,39,43,52,111,116,128,189],"bacterial":[7,30],"meningitis..":[8],"Bacteria":[9],"can":[10,22,180],"be":[11,181],"transmitted":[12],"by":[13,58,138,146],"carriers":[14],"through":[15],"droplets":[17],"respiratory":[19],"secretions":[20],"and":[21,66,85,97,118,130,136,161],"only":[23],"infect":[24],"humans.":[25],"The":[26],"mortality":[27],"rate":[28],"meningitis":[31],"very":[33],"high":[34],"even":[35],"after":[36],"discovery":[38],"many":[40],"antibiotics.":[41],"Acquisition":[42],"iron":[44,99],"major":[47],"determinant":[48],"in":[49,101],"pathogenesis":[51],"which":[55,90,104],"fulfilled":[57],"human":[59,95],"host":[60],"proteins":[61,174],"like":[62],"transferrin,":[63,96],"lactoferrin,":[64],"hemoglobin,":[65],"haptoglobin-hemoglobin.":[67],"Present":[68],"study":[69],"performed":[71,145],"on":[72],"transferrin":[73,77],"binding":[74,78,82,87,171,178],"protein":[75,79,83,88],"A,":[76],"B,":[80],"lactoferrin":[81,86,98],"A":[84],"B":[89],"together":[91],"constitutes":[92],"receptors":[93],"for":[94,108,183,186],"complex":[100],"menningitidis":[103],"further":[105],"are":[106,120,132,144,159,163],"responsible":[107],"transport":[110],"essential":[112],"iron.":[113],"Crystal":[114],"structures":[115],"TbpA":[117],"TbpB":[119],"taken":[121],"from":[122,134],"Protein":[123],"data":[124],"bank":[125],"while":[126],"sequences":[127],"LbpA":[129],"LbpB":[131],"retrieved":[133],"NCBI":[135],"modeled":[137],"using":[139],"Geno3D.":[140],"Molecular":[141],"docking":[142],"studies":[143],"taking":[147],"Juglone":[148,168],"or":[149],"5":[150],"hydroxy":[151],"1-4":[152],"naphthoqinone":[153],"as":[154],"a":[155],"ligand.":[156],"Binding":[157],"energies":[158,179],"calculated":[160],"interactions":[162],"studied.":[164],"Our":[165],"findings":[166],"suggest":[167],"shows":[169],"effective":[170],"with":[172,175],"these":[173],"much":[176],"lesser":[177],"used":[182],"clinical":[184],"trials":[185],"treatment":[188],"meningitis.":[190]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
