{"id":"https://openalex.org/W2188769240","doi":null,"title":"EFFECTS OF ACUTE AND CHRONIC TREATMENT WITH 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) AND THE CANNABINOID RECEPTOR AGONIST WIN55,212-2 ON BEHAVIOUR AND COGNITION IN RATS","display_name":"EFFECTS OF ACUTE AND CHRONIC TREATMENT WITH 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) AND THE CANNABINOID RECEPTOR AGONIST WIN55,212-2 ON BEHAVIOUR AND COGNITION IN RATS","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2188769240","mag":"2188769240"},"language":"en","primary_location":{"id":"pmh:oai:elib.suub.uni-bremen.de:DISS/00102588","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00102588","pdf_url":null,"source":{"id":"https://openalex.org/S7407064325","display_name":"State and University Library Bremen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nbn-resolving.de/<identifier scheme=\"urn:nbn:de\">urn:nbn:de:gbv:46-00102588-11</identifier>","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058929087","display_name":"Sybille Schulz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Schulz, Sybille","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058929087"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.43630000948905945,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.43630000948905945,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/win-55-212-2","display_name":"WIN 55,212-2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.781000018119812},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.7689999938011169},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9879999756813049},{"id":"https://openalex.org/keywords/body-temperature","display_name":"body temperature","score":0.984000027179718},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pubertal-rats","display_name":"pubertal rats","score":0.6949999928474426},{"id":"https://openalex.org/keywords/brain-myelination","display_name":"brain myelination","score":0.9660000205039978},{"id":"https://openalex.org/keywords/age-related-susceptibility","display_name":"age-related susceptibility","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.9163777828216553},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7334736585617065},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6014602780342102},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.5881329774856567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4916549324989319},{"id":"https://openalex.org/C2910065304","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid Receptor Agonists","level":5,"score":0.4566061496734619},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.45408394932746887},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33410996198654175},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30531835556030273},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21305304765701294}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:elib.suub.uni-bremen.de:DISS/00102588","doi":null,"is_oa":false,"landing_page_url":"http://elib.suub.uni-bremen.de/peid=D00102588","pdf_url":null,"source":{"id":"https://openalex.org/S7407064325","display_name":"State and University Library Bremen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nbn-resolving.de/<identifier scheme=\"urn:nbn:de\">urn:nbn:de:gbv:46-00102588-11</identifier>","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":275,"referenced_works":["https://openalex.org/W2956182","https://openalex.org/W171174060","https://openalex.org/W196124280","https://openalex.org/W1253199717","https://openalex.org/W1529994759","https://openalex.org/W1533710606","https://openalex.org/W1565690012","https://openalex.org/W1588615075","https://openalex.org/W1611256317","https://openalex.org/W1801725150","https://openalex.org/W1832918544","https://openalex.org/W1836729582","https://openalex.org/W1863156541","https://openalex.org/W1886032183","https://openalex.org/W1933765108","https://openalex.org/W1959296941","https://openalex.org/W1960526592","https://openalex.org/W1961696944","https://openalex.org/W1962078571","https://openalex.org/W1964248842","https://openalex.org/W1965833191","https://openalex.org/W1965987414","https://openalex.org/W1967221192","https://openalex.org/W1968436488","https://openalex.org/W1968643679","https://openalex.org/W1968958292","https://openalex.org/W1970073509","https://openalex.org/W1970670051","https://openalex.org/W1971101392","https://openalex.org/W1971746914","https://openalex.org/W1972864533","https://openalex.org/W1972977388","https://openalex.org/W1973183930","https://openalex.org/W1973466311","https://openalex.org/W1973519689","https://openalex.org/W1973743872","https://openalex.org/W1975788629","https://openalex.org/W1977212500","https://openalex.org/W1977654997","https://openalex.org/W1979169556","https://openalex.org/W1979858655","https://openalex.org/W1979911708","https://openalex.org/W1982988839","https://openalex.org/W1984518599","https://openalex.org/W1985645068","https://openalex.org/W1985795350","https://openalex.org/W1985916296","https://openalex.org/W1985970204","https://openalex.org/W1986003147","https://openalex.org/W1986219496","https://openalex.org/W1987613482","https://openalex.org/W1988829061","https://openalex.org/W1989145123","https://openalex.org/W1991220753","https://openalex.org/W1991296923","https://openalex.org/W1991397429","https://openalex.org/W1991718370","https://openalex.org/W1992095498","https://openalex.org/W1992116349","https://openalex.org/W1993455459","https://openalex.org/W1994144122","https://openalex.org/W1996278273","https://openalex.org/W1996548848","https://openalex.org/W1998101912","https://openalex.org/W1998839982","https://openalex.org/W2000101285","https://openalex.org/W2000779397","https://openalex.org/W2001803470","https://openalex.org/W2001810970","https://openalex.org/W2004193318","https://openalex.org/W2005480796","https://openalex.org/W2007485514","https://openalex.org/W2008463180","https://openalex.org/W2009732294","https://openalex.org/W2010260292","https://openalex.org/W2011004475","https://openalex.org/W2011580261","https://openalex.org/W2011659276","https://openalex.org/W2012921837","https://openalex.org/W2012979366","https://openalex.org/W2015441565","https://openalex.org/W2015614945","https://openalex.org/W2015724371","https://openalex.org/W2016310399","https://openalex.org/W2017443598","https://openalex.org/W2019125590","https://openalex.org/W2021015465","https://openalex.org/W2021806579","https://openalex.org/W2022305864","https://openalex.org/W2023941576","https://openalex.org/W2024086265","https://openalex.org/W2025059824","https://openalex.org/W2025075297","https://openalex.org/W2025471327","https://openalex.org/W2025546081","https://openalex.org/W2028998494","https://openalex.org/W2029181309","https://openalex.org/W2030201174","https://openalex.org/W2030238247","https://openalex.org/W2031023109","https://openalex.org/W2031159576","https://openalex.org/W2032005802","https://openalex.org/W2033237025","https://openalex.org/W2035590629","https://openalex.org/W2036019952","https://openalex.org/W2036272035","https://openalex.org/W2036465008","https://openalex.org/W2036570302","https://openalex.org/W2037164190","https://openalex.org/W2037275923","https://openalex.org/W2037305376","https://openalex.org/W2038682321","https://openalex.org/W2039265593","https://openalex.org/W2039613893","https://openalex.org/W2040311761","https://openalex.org/W2041421155","https://openalex.org/W2041973096","https://openalex.org/W2042007776","https://openalex.org/W2043934883","https://openalex.org/W2048118307","https://openalex.org/W2048841731","https://openalex.org/W2050119023","https://openalex.org/W2050392483","https://openalex.org/W2050937255","https://openalex.org/W2050985584","https://openalex.org/W2054130973","https://openalex.org/W2055176982","https://openalex.org/W2055205182","https://openalex.org/W2056188558","https://openalex.org/W2058634132","https://openalex.org/W2058842534","https://openalex.org/W2059419081","https://openalex.org/W2059551625","https://openalex.org/W2059889162","https://openalex.org/W2061489773","https://openalex.org/W2063166975","https://openalex.org/W2063859365","https://openalex.org/W2064128689","https://openalex.org/W2064180977","https://openalex.org/W2064576666","https://openalex.org/W2065494210","https://openalex.org/W2065820941","https://openalex.org/W2065838665","https://openalex.org/W2067885398","https://openalex.org/W2069379969","https://openalex.org/W2069605484","https://openalex.org/W2070953022","https://openalex.org/W2071694134","https://openalex.org/W2072441360","https://openalex.org/W2072624253","https://openalex.org/W2073065955","https://openalex.org/W2073158960","https://openalex.org/W2073494415","https://openalex.org/W2074592758","https://openalex.org/W2075160582","https://openalex.org/W2075619261","https://openalex.org/W2076066147","https://openalex.org/W2076959168","https://openalex.org/W2077030928","https://openalex.org/W2077152295","https://openalex.org/W2077269794","https://openalex.org/W2077420576","https://openalex.org/W2078291595","https://openalex.org/W2080017984","https://openalex.org/W2080649553","https://openalex.org/W2080835184","https://openalex.org/W2082787971","https://openalex.org/W2084127135","https://openalex.org/W2087388617","https://openalex.org/W2089641976","https://openalex.org/W2093419170","https://openalex.org/W2094414770","https://openalex.org/W2095299522","https://openalex.org/W2097021306","https://openalex.org/W2099241624","https://openalex.org/W2099638088","https://openalex.org/W2100352065","https://openalex.org/W2101563375","https://openalex.org/W2102581653","https://openalex.org/W2103255168","https://openalex.org/W2105342126","https://openalex.org/W2106180565","https://openalex.org/W2106607972","https://openalex.org/W2106713530","https://openalex.org/W2108182383","https://openalex.org/W2110096690","https://openalex.org/W2110876011","https://openalex.org/W2111809096","https://openalex.org/W2112422249","https://openalex.org/W2112755850","https://openalex.org/W2112924959","https://openalex.org/W2113271442","https://openalex.org/W2113531708","https://openalex.org/W2114381064","https://openalex.org/W2115241864","https://openalex.org/W2115290225","https://openalex.org/W2116536917","https://openalex.org/W2116562654","https://openalex.org/W2118707538","https://openalex.org/W2119898593","https://openalex.org/W2120309987","https://openalex.org/W2121894737","https://openalex.org/W2122464153","https://openalex.org/W2123907272","https://openalex.org/W2124416404","https://openalex.org/W2125104309","https://openalex.org/W2127372827","https://openalex.org/W2127538073","https://openalex.org/W2129836920","https://openalex.org/W2130327966","https://openalex.org/W2130587723","https://openalex.org/W2130643119","https://openalex.org/W2130687867","https://openalex.org/W2131218306","https://openalex.org/W2131489415","https://openalex.org/W2132011757","https://openalex.org/W2133377406","https://openalex.org/W2134305481","https://openalex.org/W2135015648","https://openalex.org/W2135085529","https://openalex.org/W2135847541","https://openalex.org/W2136415863","https://openalex.org/W2136692532","https://openalex.org/W2136906168","https://openalex.org/W2138853567","https://openalex.org/W2139607193","https://openalex.org/W2139900591","https://openalex.org/W2140142910","https://openalex.org/W2141206715","https://openalex.org/W2141638015","https://openalex.org/W2142786692","https://openalex.org/W2143437320","https://openalex.org/W2143985916","https://openalex.org/W2144109697","https://openalex.org/W2145452630","https://openalex.org/W2145747108","https://openalex.org/W2146561516","https://openalex.org/W2148562084","https://openalex.org/W2149354807","https://openalex.org/W2149601015","https://openalex.org/W2150258126","https://openalex.org/W2155111399","https://openalex.org/W2155890773","https://openalex.org/W2156291077","https://openalex.org/W2157302628","https://openalex.org/W2161510689","https://openalex.org/W2161976633","https://openalex.org/W2162010222","https://openalex.org/W2163893984","https://openalex.org/W2164164342","https://openalex.org/W2165487404","https://openalex.org/W2165518874","https://openalex.org/W2165892706","https://openalex.org/W2166756269","https://openalex.org/W2166799944","https://openalex.org/W2167091782","https://openalex.org/W2167729602","https://openalex.org/W2168545748","https://openalex.org/W2169132085","https://openalex.org/W2169182197","https://openalex.org/W2170016806","https://openalex.org/W2170123679","https://openalex.org/W2170588940","https://openalex.org/W2171120634","https://openalex.org/W2171275714","https://openalex.org/W2256476897","https://openalex.org/W2261451494","https://openalex.org/W2314973408","https://openalex.org/W2316917653","https://openalex.org/W2322781876","https://openalex.org/W2329652225","https://openalex.org/W2333821097","https://openalex.org/W2419612826","https://openalex.org/W2544406567","https://openalex.org/W2598878392"],"related_works":["https://openalex.org/W7009298978","https://openalex.org/W2005480796","https://openalex.org/W2316139973","https://openalex.org/W1991220753","https://openalex.org/W1580800840","https://openalex.org/W2333821097","https://openalex.org/W2178408215","https://openalex.org/W2076066147","https://openalex.org/W2059618143","https://openalex.org/W1996548848"],"abstract_inverted_index":{"MDMA":[0,124],"(3,4-methylenedioxymetamphethamine,":[1],"ecstasy":[2,62],")":[3],"is":[4,59,74,98,174],"one":[5],"of":[6,123,136,165,181,205],"the":[7,17,23,32,68,75,106,121,126],"most":[8,76],"popular":[9],"illicit":[10],"recreational":[11],"drugs":[12,92],"among":[13],"young":[14],"adults.":[15],"However,":[16],"underlying":[18],"neurobiological":[19],"mechanisms":[20],"responsible":[21],"for":[22],"physiological,":[24],"behavioural":[25],"and":[26,40,50,67,93,102,111,125,143,150,193],"psychological":[27],"effects,":[28],"as":[29,31,38,90,147,157,159,169,171,188,190],"well":[30,158,170,189],"influence":[33,122],"on":[34,133],"cognitive":[35,100],"functions":[36],"such":[37,146],"memory":[39,139],"decision":[41,137],"making":[42],"are":[43,64,87,116,199],"still":[44],"not":[45],"fully":[46],"examined.":[47],"Furthermore,":[48],"if":[49],"to":[51,178,201],"what":[52],"extend":[53],"this":[54],"drug":[55,81,206],"has":[56],"neurotoxic":[57],"properties":[58],"debated.":[60],"Most":[61],"users":[63],"polydrug":[65],"users,":[66],"majority":[69],"concomitantly":[70],"consumes":[71],"cannabis.":[72],"Cannabis":[73],"frequently":[77],"consumed":[78],"illegal":[79],"psychoactive":[80],"world":[82],"wide.":[83],"While":[84],"cannabis":[85],"products":[86],"generally":[88],"perceived":[89],"soft":[91],"their":[94,172,194],"potential":[95],"medical":[96],"usefulness":[97],"progressing,":[99],"impairments":[101],"long-term":[103],"alterations":[104],"in":[105,114,176],"brain,":[107],"especially":[108],"following":[109],"prolonged":[110],"heavy":[112],"use":[113],"adolescence,":[115],"observed.":[117],"This":[118],"thesis":[119],"investigates":[120],"synthetic":[127],"cannabinoid":[128],"receptor":[129],"agonist,":[130],"WIN55,212-2":[131],"(WIN),":[132],"different":[134],"forms":[135],"making,":[138],"function,":[140],"locomotor":[141],"activity":[142],"physiological":[144],"parameters":[145],"body":[148],"temperature":[149],"food":[151],"intake.":[152],"Within":[153,184],"both":[154],"an":[155],"acute":[156],"chronic":[160,185],"systemic":[161],"administration":[162],"schedule,":[163],"effects":[164],"each":[166],"substance":[167],"alone":[168],"combination":[173],"tested":[175],"order":[177],"mimic":[179],"co-consumption":[180],"these":[182],"drugs.":[183],"treatment,":[186],"adult":[187],"pubertal":[191],"rats":[192],"respective":[195],"brain":[196],"myelination":[197],"levels":[198],"examined":[200],"determine":[202],"vulnerable":[203],"periods":[204],"consumption":[207],"or":[208],"age-related":[209],"differences.":[210]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
