{"id":"https://openalex.org/W2188743866","doi":null,"title":"Vitamin C inhibit the proliferation, migration and epithelial-mesenchymal-transition of lens epithelial cells by destabilizing HIF-1\u03b1.","display_name":"Vitamin C inhibit the proliferation, migration and epithelial-mesenchymal-transition of lens epithelial cells by destabilizing HIF-1\u03b1.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2188743866","mag":"2188743866","pmid":"https://pubmed.ncbi.nlm.nih.gov/26628999","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4658888"},"language":"en","primary_location":{"id":"pmid:26628999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26628999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4658888/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079451346","display_name":"Lin Zhao","orcid":"https://orcid.org/0000-0002-2852-8558","observed_orcids":["https://orcid.org/0000-0002-2852-8558"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhao","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076006457","display_name":"Yan-long Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanlong Quan","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035598952","display_name":"Jianming Wang","orcid":"https://orcid.org/0000-0003-4118-6289","observed_orcids":["https://orcid.org/0000-0003-4118-6289"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianming Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828782","display_name":"Feng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113935581","display_name":"Yuping Zheng","orcid":"https://orcid.org/0009-0001-1936-7625","observed_orcids":["https://orcid.org/0009-0001-1936-7625"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuping Zheng","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065797500","display_name":"Aiyi Zhou","orcid":"https://orcid.org/0000-0003-4745-3894","observed_orcids":["https://orcid.org/0000-0003-4745-3894"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aiyi Zhou","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, China","institution_ids":["https://openalex.org/I4210131893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210131893"],"apc_list":null,"apc_paid":null,"fwci":1.4961,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79409462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"9","first_page":"15155","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lens-epithelial-cells","display_name":"lens epithelial cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/posterior-capsule-opacification","display_name":"posterior capsule opacification","score":0.8510000109672546},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.6269999742507935},{"id":"https://openalex.org/keywords/proline-hydroxylation","display_name":"proline hydroxylation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":1.0},{"id":"https://openalex.org/keywords/twist","display_name":"Twist","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cataract-surgery-complications","display_name":"cataract surgery complications","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.6776621341705322},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.5889678597450256},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5115088224411011},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4477602243423462},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.44615769386291504},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4344263970851898},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4286131262779236},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4103662669658661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3836252987384796},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26317310333251953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25086188316345215},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06359884142875671},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.04149386286735535}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:26628999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26628999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4658888","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4658888/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2188743866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26628999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4658888","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4658888/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1532822464","https://openalex.org/W1571263028","https://openalex.org/W1967489328","https://openalex.org/W1972032694","https://openalex.org/W1977519421","https://openalex.org/W1981158116","https://openalex.org/W1988736991","https://openalex.org/W1991346678","https://openalex.org/W2002291369","https://openalex.org/W2004036400","https://openalex.org/W2008139703","https://openalex.org/W2013898919","https://openalex.org/W2016360721","https://openalex.org/W2020330955","https://openalex.org/W2025486904","https://openalex.org/W2031232505","https://openalex.org/W2032808172","https://openalex.org/W2041677910","https://openalex.org/W2047021964","https://openalex.org/W2051056271","https://openalex.org/W2054388347","https://openalex.org/W2061476658","https://openalex.org/W2065779229","https://openalex.org/W2069641472","https://openalex.org/W2069663698","https://openalex.org/W2077426908","https://openalex.org/W2116774399","https://openalex.org/W2119604341","https://openalex.org/W2120742250","https://openalex.org/W2122802536","https://openalex.org/W2123179922","https://openalex.org/W2126747397","https://openalex.org/W2128601907","https://openalex.org/W2134361367","https://openalex.org/W2139923937","https://openalex.org/W2147478932","https://openalex.org/W2152239318","https://openalex.org/W2152985792","https://openalex.org/W2154589460","https://openalex.org/W2158794894","https://openalex.org/W2165063859","https://openalex.org/W2270515169","https://openalex.org/W4389992705","https://openalex.org/W7096465494"],"related_works":["https://openalex.org/W3022861793","https://openalex.org/W7039605733","https://openalex.org/W2800366544","https://openalex.org/W2030948963","https://openalex.org/W3108234092","https://openalex.org/W2739975462","https://openalex.org/W3112742483","https://openalex.org/W2344339476","https://openalex.org/W7213561281","https://openalex.org/W4283313991"],"abstract_inverted_index":{"Posterior":[0],"capsular":[1],"opacification":[2],"(PCO),":[3],"the":[4,14,22,33,46,63,80,87,97,114,128,140,152,167,172,179,193],"main":[5],"complication":[6],"of":[7,21,35,67,83,89,99,104,118,154,174,195,200],"cataract":[8],"surgery,":[9],"is":[10],"mainly":[11],"caused":[12],"by":[13,171,205],"proliferation,":[15,196],"migration,":[16,197],"and":[17,51,65,85,116,130,198],"epithelial-mesenchymal":[18],"transition":[19],"(EMT)":[20],"residual":[23],"lens":[24,69,120,135,202],"epithelial":[25,70,121,136,203],"cells":[26,137,204],"(LECs).Vitamin":[27],"C":[28,50,60,77,93,125,146,164,188],"was":[29,110,147],"reported":[30],"to":[31,112,150],"reduce":[32,86],"risk":[34],"forming":[36],"a":[37,190],"cataract.":[38],"However,":[39],"there":[40],"has":[41],"been":[42],"no":[43],"study":[44],"showing":[45],"association":[47],"between":[48],"vitamin":[49,59,76,92,124,145,163,187],"PCO.":[52],"In":[53],"this":[54],"study,":[55],"we":[56],"found":[57,74,111,149,161],"that":[58,75,162,186],"could":[61,78,94,126,165],"inhibit":[62,96,127,151],"migration":[64,117,131],"proliferation":[66,115,129],"human":[68,119,201],"cells.":[71,122,143],"We":[72,159],"also":[73,148],"increase":[79,113],"proline":[81],"hydroxylation":[82],"HIF-1\u03b1":[84,101,106,109,176],"activity":[88,98],"HIF-1\u03b1.":[90,181,207],"Moreover,":[91],"not":[95,139,178],"proline-mutant":[100,108,141,180],"(402/564).":[102],"Overexpression":[103],"wild-type":[105,133,175],"or":[107],"Differently,":[123],"in":[132,192],"HIF-1\u03b1-overexpressing":[134,142],"but":[138,177],"Additionally,":[144],"expression":[153],"EMT":[155,168,199],"transcription":[156],"factors":[157],"TWIST.":[158],"then":[160],"repress":[166],"phenotypes":[169],"induced":[170],"overexpression":[173],"These":[182],"results":[183],"provide":[184],"evidence":[185],"plays":[189],"role":[191],"repression":[194],"destabilizing":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
