{"id":"https://openalex.org/W2188698686","doi":null,"title":"Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.","display_name":"Evidence for a tumour suppressor function of SETD2 in human breast cancer: a new hypothesis.","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2188698686","mag":"2188698686","pmid":"https://pubmed.ncbi.nlm.nih.gov/20944102"},"language":"en","primary_location":{"id":"pmid:20944102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111790837","display_name":"Robert F. Newbold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59433898","display_name":"Brunel University of London","ror":"https://ror.org/00dn4t376","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I59433898"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R F Newbold","raw_affiliation_strings":["The Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex UB8 3PH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brunel Institute of Cancer Genetics and Pharmacogenomics, Brunel University, Uxbridge, Middlesex UB8 3PH, UK","institution_ids":["https://openalex.org/I59433898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006935581","display_name":"Kefah Mokbel","orcid":"https://orcid.org/0000-0001-7255-7850","observed_orcids":["https://orcid.org/0000-0001-7255-7850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Mokbel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4306,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.57860655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"9","first_page":"3309","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.365200012922287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.30320000648498535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setd2","display_name":"SETD2","score":1.0},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.925000011920929},{"id":"https://openalex.org/keywords/telomerase-regulation","display_name":"telomerase regulation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/htert-promoter","display_name":"hTERT promoter","score":0.8169999718666077},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.6881999969482422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5956533551216125},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.5654325485229492},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.541504979133606},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.504402756690979},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.494704931974411},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.48628103733062744},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4667750895023346},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45299482345581055},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.42251020669937134},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36617419123649597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27859973907470703},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.23415857553482056},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14509832859039307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1273709237575531}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20944102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20944102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2188698686","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/20944102","pdf_url":null,"source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Anticancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2019434001","https://openalex.org/W2038883903","https://openalex.org/W2045692943","https://openalex.org/W2072257321","https://openalex.org/W2075956161","https://openalex.org/W2085017439","https://openalex.org/W2092712702","https://openalex.org/W2102141072","https://openalex.org/W2102936230","https://openalex.org/W2127573529","https://openalex.org/W2130109827","https://openalex.org/W2144522793"],"related_works":["https://openalex.org/W2072257321","https://openalex.org/W3012742951","https://openalex.org/W2324122340","https://openalex.org/W2729809472","https://openalex.org/W2004204007","https://openalex.org/W1863047586","https://openalex.org/W2986259168","https://openalex.org/W4292466761","https://openalex.org/W4380086498","https://openalex.org/W2584595943"],"abstract_inverted_index":{"BACKGROUND:":[0],"SET":[1],"domain":[2],"containing":[3],"protein":[4,114,144],"2":[5],"(SETD2)":[6],"is":[7,12,57],"a":[8,23,68,142,158],"histone":[9,185,196],"methyltransferase":[10],"that":[11,45,59,154],"involved":[13],"in":[14,28,41,46,52,118,129,135,146,190,203],"transcriptional":[15],"elongation.":[16],"We":[17],"previously":[18],"demonstrated":[19,141],"SETD2":[20,39,66,94,113,124,155,165,193],"to":[21,37,133],"be":[22,199],"potential":[24,210],"tumour":[25,69,78,136,159,211],"suppressor":[26,70,160,212],"gene":[27],"breast":[29,42,49],"cancer.":[30],"The":[31,89],"aim":[32],"of":[33,63,65,77,91,93,123,167,184,187,195,214],"this":[34,204],"study":[35,150],"was":[36,115],"compare":[38],"expression":[40,145],"cancer":[43],"with":[44,109,169],"adjacent":[47,80],"non-cancerous":[48,81],"tissue":[50,82],"(ANCT)":[51,83],"paired":[53],"samples.":[54,120],"A":[55],"hypothesis":[56,163],"proposed":[58],"explains":[60],"the":[61,182,200,209],"mode":[62,166],"action":[64,168],"as":[67],"gene.":[71,161],"MATERIALS":[72],"AND":[73],"METHODS:":[74],"Paired":[75],"samples":[76,137],"and":[79,102],"from":[84],"25":[85],"patients":[86],"were":[87,95,126],"analysed.":[88],"levels":[90],"transcription":[92],"determined":[96],"using":[97],"quantitative":[98],"polymerase":[99],"chain":[100,205],"reaction":[101],"normalized":[103],"against":[104,112],"cytokeratin":[105],"19.":[106],"Immunohistochemical":[107],"staining":[108],"appropriate":[110],"antibodies":[111],"also":[116,140],"performed":[117],"selected":[119],"RESULTS:":[121],"Levels":[122],"mRNA":[125],"significantly":[127],"higher":[128,143],"ANCT":[130],"when":[131],"compared":[132],"those":[134],"(p=0.01).":[138],"Immunohistochemistry":[139],"ANCT.":[147],"CONCLUSION:":[148],"This":[149],"offers":[151],"further":[152],"evidence":[153],"behaves":[156],"like":[157],"Our":[162],"links":[164],"telomerase":[170,174,191],"regulation":[171],"through":[172],"human":[173],"reverse":[175],"transcriptase":[176],"(hTERT).":[177],"Several":[178],"studies":[179],"have":[180],"emphasised":[181],"importance":[183],"methylation":[186,197],"hTERT":[188],"promotor":[189],"regulation.":[192],"function":[194,213],"could":[198,207],"missing":[201],"link":[202],"which":[206],"explain":[208],"SETD2.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}