{"id":"https://openalex.org/W2188691956","doi":null,"title":"NEW 6H- INDOLO(2,3-B)QUINOLINE O-AMINOGLYCOSIDES OVERCOMING ANTICANCER MULTIDRUG RESISTANCE","display_name":"NEW 6H- INDOLO(2,3-B)QUINOLINE O-AMINOGLYCOSIDES OVERCOMING ANTICANCER MULTIDRUG RESISTANCE","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2188691956","mag":"2188691956"},"language":"en","primary_location":{"id":"mag:2188691956","doi":null,"is_oa":false,"landing_page_url":"https://www.arpapress.com/Volumes/JPCS/Vol7/JPCS_7_02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056354071","display_name":"Katarzyna Badowska-Ros\u0142onek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Badowska-Ros\u0142onek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024409118","display_name":"Joanna Godlewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Godlewska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054211044","display_name":"Marta \u015awitalska","orcid":"https://orcid.org/0000-0001-7920-2251","observed_orcids":["https://orcid.org/0000-0001-7920-2251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta \u015awitalska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7920-2251","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057754198","display_name":"Ma\u0142gorzata Piskozub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma\u0142gorzata Piskozub","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056533214","display_name":"Wanda Peczynska-Czoch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Peczy\u0144ska-Czoch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022446752","display_name":"Joanna Wietrzyk","orcid":"https://orcid.org/0000-0003-4980-6606","observed_orcids":["https://orcid.org/0000-0003-4980-6606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Wietrzyk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4980-6606","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056658473","display_name":"\u0141ukasz Kaczmarek","orcid":"https://orcid.org/0000-0001-8222-8380","observed_orcids":["https://orcid.org/0000-0001-8222-8380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0141ukasz Kaczmarek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8222-8380","affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"L Hirszfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Hirszfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1389,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42762641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.4611999988555908,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.21070000529289246,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daunorubicin","display_name":"daunorubicin","score":0.6809999942779541},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6520000100135803},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.843999981880188},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9769999980926514},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8500000238418579},{"id":"https://openalex.org/keywords/g0-g1-arrest","display_name":"G0/G1 arrest","score":0.8970000147819519},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.800000011920929},{"id":"https://openalex.org/keywords/uterine-sarcoma","display_name":"uterine sarcoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/promyelocytic-leukemia","display_name":"promyelocytic leukemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7281032800674438},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.6262632608413696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.571380078792572},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.5607683062553406},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.5480515956878662},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5115042924880981},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4650617241859436},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45897167921066284},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.44707056879997253},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.41192498803138733},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3772428631782532},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34786349534988403},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3218751549720764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30476701259613037},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.28726089000701904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17632311582565308},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.13602274656295776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10206988453865051},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0669015645980835},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188691956","doi":null,"is_oa":false,"landing_page_url":"https://www.arpapress.com/Volumes/JPCS/Vol7/JPCS_7_02.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W286624360","https://openalex.org/W1960652777","https://openalex.org/W2008750515","https://openalex.org/W2024741431","https://openalex.org/W2036571689","https://openalex.org/W2044137790","https://openalex.org/W2044565224","https://openalex.org/W2058653197","https://openalex.org/W2070038334","https://openalex.org/W2077301074","https://openalex.org/W2102071915","https://openalex.org/W2109689528","https://openalex.org/W2114918609","https://openalex.org/W2186387366","https://openalex.org/W2851118861","https://openalex.org/W2882806284"],"related_works":["https://openalex.org/W2480254396","https://openalex.org/W2024741431","https://openalex.org/W2027371251","https://openalex.org/W2050558159","https://openalex.org/W2082980420","https://openalex.org/W2109634653","https://openalex.org/W1968225251","https://openalex.org/W1960652777","https://openalex.org/W2949397773","https://openalex.org/W4239418540"],"abstract_inverted_index":{"Novel":[0],"derivatives":[1],"of":[2,44],"6H-":[3],"indolo(2,3-b)quinoline":[4],"substituted":[5],"at":[6],"C-2,":[7],"C-9":[8],"or":[9,15,24,98],"N-6":[10],"positions":[11],"with":[12,18],"O-":[13],"L-daunosamine":[14],"L-acosamine":[16],"connected":[17],"the":[19,54,58,63,96,105],"chromophore":[20],"via":[21],"an":[22],"alkoxy":[23],"alkyl":[25],"linker":[26],"were":[27,32],"synthesized.":[28],"The":[29,92],"obtained":[30],"compounds":[31,64,93],"evaluated":[33],"in":[34,79,104],"vitro":[35],"for":[36,49],"their":[37,50],"cytotoxic":[38,67],"activity":[39,68],"against":[40,69],"several":[41],"cell":[42,55,101],"lines":[43],"different":[45],"origin":[46],"and":[47,72,75],"tested":[48,65],"ability":[51],"to":[52],"influence":[53],"cycle":[56,102],"using":[57],"flow":[59],"cytometric":[60],"analysis.":[61],"All":[62],"show":[66],"A549,":[70],"MCF-7":[71],"Hs294T":[73],"cells":[74],"overcome":[76],"multidrug":[77],"resistance":[78],"colorectal":[80],"adenocarcinoma":[81],"LoVo/DX,":[82],"uterine":[83],"sarcoma":[84],"MES-SA/DX5":[85],"as":[86,88],"well":[87],"promyelocytic":[89],"leukemia":[90,108],"HL-60/MX2.":[91],"also":[94],"induce":[95],"G2M":[97],"G0/G1":[99],"phase":[100],"arrest":[103],"Jurkat":[106],"T-cell":[107],"cells.":[109]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}