{"id":"https://openalex.org/W2188680094","doi":"https://doi.org/10.38212/2224-6614.2099","title":"Clinical effect and mechanism of alkaline reduced water","display_name":"Clinical effect and mechanism of alkaline reduced water","publication_year":2020,"publication_date":"2020-07-14","ids":{"openalex":"https://openalex.org/W2188680094","doi":"https://doi.org/10.38212/2224-6614.2099","mag":"2188680094"},"language":"en","primary_location":{"id":"doi:10.38212/2224-6614.2099","doi":"https://doi.org/10.38212/2224-6614.2099","is_oa":true,"landing_page_url":"https://doi.org/10.38212/2224-6614.2099","pdf_url":null,"source":{"id":"https://openalex.org/S155791383","display_name":"Journal of Food and Drug Analysis","issn_l":"1021-9498","issn":["1021-9498","2224-6614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Drug Analysis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.38212/2224-6614.2099","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044155210","display_name":"Rosa Mistica C. Ignacio","orcid":"https://orcid.org/0000-0002-5343-4190","observed_orcids":["https://orcid.org/0000-0002-5343-4190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.M.C. Ignacio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052126427","display_name":"Kyung-Bok Joo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.-B. Joo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108285119","display_name":"Kyung Jin Lee","orcid":"https://orcid.org/0000-0002-9448-8291","observed_orcids":["https://orcid.org/0000-0002-9448-8291","https://orcid.org/0009-0003-0043-0633","https://orcid.org/0000-0002-6709-3235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.-J. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1367,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.92082985,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14488","display_name":"Chemical and Physical Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13108","display_name":"Therapeutic Uses of Natural Elements","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alkaline-ionized-water","display_name":"alkaline ionized water","score":0.9599999785423279},{"id":"https://openalex.org/keywords/spring-water","display_name":"spring water","score":0.6639999747276306},{"id":"https://openalex.org/keywords/hydrogen-rich-water","display_name":"hydrogen-rich water","score":0.6660000085830688},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.675000011920929},{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.3630000054836273},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6150000095367432},{"id":"https://openalex.org/keywords/bathing","display_name":"bathing","score":0.9440000057220459},{"id":"https://openalex.org/keywords/health-benefits","display_name":"health benefits","score":0.5120000243186951},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5414891242980957},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.47264403104782104},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.43051978945732117},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.4194391667842865},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4173225164413452},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3764343857765198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28440654277801514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2568419873714447}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.38212/2224-6614.2099","doi":"https://doi.org/10.38212/2224-6614.2099","is_oa":true,"landing_page_url":"https://doi.org/10.38212/2224-6614.2099","pdf_url":null,"source":{"id":"https://openalex.org/S155791383","display_name":"Journal of Food and Drug Analysis","issn_l":"1021-9498","issn":["1021-9498","2224-6614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Drug Analysis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.38212/2224-6614.2099","doi":"https://doi.org/10.38212/2224-6614.2099","is_oa":true,"landing_page_url":"https://doi.org/10.38212/2224-6614.2099","pdf_url":null,"source":{"id":"https://openalex.org/S155791383","display_name":"Journal of Food and Drug Analysis","issn_l":"1021-9498","issn":["1021-9498","2224-6614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food and Drug Analysis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/6","score":0.6618000268936157,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W2572278","https://openalex.org/W1546128850","https://openalex.org/W1979138803","https://openalex.org/W1980495340","https://openalex.org/W2009372748","https://openalex.org/W2031923474","https://openalex.org/W2039843492","https://openalex.org/W2044190772","https://openalex.org/W2066906561","https://openalex.org/W2071167046","https://openalex.org/W2073530866","https://openalex.org/W2083710829","https://openalex.org/W2105645865","https://openalex.org/W2128705098","https://openalex.org/W2143703619","https://openalex.org/W2145921233","https://openalex.org/W2168162793","https://openalex.org/W2254612894","https://openalex.org/W2401244928","https://openalex.org/W2464914749","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4417178272","https://openalex.org/W7220185449","https://openalex.org/W3197759888","https://openalex.org/W4399204881","https://openalex.org/W2905753996","https://openalex.org/W2074972111","https://openalex.org/W1983032762","https://openalex.org/W4310248795","https://openalex.org/W1843593028","https://openalex.org/W7165561651"],"abstract_inverted_index":{"Recently,":[0],"alkaline":[1,151,184],"ionized":[2],"water":[3,7,136,153,157,186],"(AIW)":[4],"generated":[5],"by":[6],"electrolysis":[8],"has":[9,60],"received":[10],"increasing":[11],"attention":[12],"because":[13],"of":[14,22,34,43,58,67,75,80,83,89,97,117,127,183],"its":[15,105,124,190],"shown":[16],"benefits":[17,182],"in":[18],"treatment":[19],"and":[20,26,51,92,110,137,171,189],"prevention":[21],"diseases.":[23,145],"The":[24,95,114],"Korean":[25],"the":[27,32,41,180],"Japanese":[28],"governments":[29],"officially":[30],"acknowledged":[31],"efficacy":[33],"AIW":[35,59,98,118,163],"as":[36,65,119],"a":[37,165],"novel":[38],"material":[39],"for":[40],"improvement":[42],"abnormal":[44],"intestinal":[45],"fermentation,":[46],"chronic":[47],"diarrhea,":[48],"gastric":[49],"hyperacidity":[50],"dyspepsia.":[52],"It":[53],"was":[54],"reported":[55],"that":[56],"intake":[57],"various":[61],"beneficial":[62],"effects":[63],"such":[64],"removal":[66],"reactive":[68],"oxygen":[69],"species,":[70],"improving":[71],"constipation,":[72],"suppressed":[73],"accumulation":[74],"body":[76],"fats,":[77],"early":[78],"expulsion":[79],"melamine,":[81],"reduction":[82,108],"ultraviolet":[84],"radiation-induced":[85],"skin":[86],"damage,":[87],"modulation":[88],"immune":[90],"response":[91],"ameliorating":[93],"diabetes.":[94],"effect":[96,167],"is":[99],"thought":[100],"to":[101,104,123,177],"be":[102],"accounted":[103],"negative":[106],"oxidation":[107],"potential,":[109],"abundant":[111],"dissolved":[112],"hydrogen.":[113],"major":[115],"role":[116],"an":[120],"antioxidant":[121],"due":[122],"high":[125],"content":[126],"hydrogen":[128,135,139],"had":[129],"long":[130],"been":[131],"established.":[132],"Furthermore,":[133],"drinking":[134],"inhaling":[138],"gas":[140],"demonstrated":[141],"protection":[142],"against":[143],"oxidative":[144],"However,":[146],"our":[147],"recent":[148],"study":[149],"on":[150,187],"reduced":[152,185],"(ARW)":[154],"from":[155,162],"spring":[156],"which":[158],"exhibits":[159],"different":[160],"properties":[161],"showed":[164],"salutary":[166],"through":[168],"oral":[169],"administration":[170],"bathing.":[172],"This":[173],"finding":[174],"led":[175],"us":[176],"explore":[178],"further":[179],"potential":[181],"health":[188],"accompanying":[191],"mechanism.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}