{"id":"https://openalex.org/W2188670720","doi":"https://doi.org/10.1192/bjp.bp.114.154526","title":"Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: Preliminary findings from a 6-year follow-up study","display_name":"Negative symptoms and longitudinal grey matter tissue loss in adolescents at risk of psychosis: Preliminary findings from a 6-year follow-up study","publication_year":2015,"publication_date":"2015-12-03","ids":{"openalex":"https://openalex.org/W2188670720","doi":"https://doi.org/10.1192/bjp.bp.114.154526","mag":"2188670720","pmid":"https://pubmed.ncbi.nlm.nih.gov/26635326"},"language":"en","primary_location":{"id":"doi:10.1192/bjp.bp.114.154526","doi":"https://doi.org/10.1192/bjp.bp.114.154526","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.114.154526","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/96BA60CA6422B78AC7ABAAD43E6A5418/S0007125000244061a.pdf/div-class-title-negative-symptoms-and-longitudinal-grey-matter-tissue-loss-in-adolescents-at-risk-of-psychosis-preliminary-findings-from-a-6-year-follow-up-study-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/96BA60CA6422B78AC7ABAAD43E6A5418/S0007125000244061a.pdf/div-class-title-negative-symptoms-and-longitudinal-grey-matter-tissue-loss-in-adolescents-at-risk-of-psychosis-preliminary-findings-from-a-6-year-follow-up-study-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037514607","display_name":"Andrew G. McKechanie","orcid":"https://orcid.org/0000-0003-4273-9906","observed_orcids":["https://orcid.org/0000-0003-4273-9906"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew G. McKechanie","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK andrew.mckechanie@ed.ac.uk","The Patrick Wild Centre, The University of Edinburgh, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK andrew.mckechanie@ed.ac.uk","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"The Patrick Wild Centre, The University of Edinburgh, Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111611876","display_name":"T. William J. Moorhead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas W. J. Moorhead","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","Division of Psychiatry, The University of Edinburgh, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Psychiatry, The University of Edinburgh, Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059327361","display_name":"Andrew C. Stanfield","orcid":"https://orcid.org/0000-0003-2459-1434","observed_orcids":["https://orcid.org/0000-0003-2459-1434"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew C. Stanfield","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","The Patrick Wild Centre, The University of Edinburgh, Edinburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"The Patrick Wild Centre, The University of Edinburgh, Edinburgh","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089456652","display_name":"Heather Clare Whalley","orcid":"https://orcid.org/0000-0002-4505-8869","observed_orcids":["https://orcid.org/0000-0002-4505-8869","https://orcid.org/0000-0001-8967-683X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather C. Whalley","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","Division of Psychiatry, The University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534412","display_name":"Eve C. Johnstone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eve C. Johnstone","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","Division of Psychiatry, The University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066795737","display_name":"Stephen M. Lawrie","orcid":"https://orcid.org/0000-0002-2444-5675","observed_orcids":["https://orcid.org/0000-0002-2444-5675"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen M. Lawrie","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","Division of Psychiatry, The University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111672786","display_name":"David G. Cunningham Owens","orcid":"https://orcid.org/0000-0003-4340-5094","observed_orcids":["https://orcid.org/0000-0003-4340-5094"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David G. C. Owens","raw_affiliation_strings":["Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","Division of Psychiatry, The University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andrew G. McKechanie, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Thomas W. J. Moorhead, PhD, Division of Psychiatry, The University of Edinburgh, Edinburgh; Andrew C. Stanfield, PhD, MRCPsych, The Patrick Wild Centre, The University of Edinburgh, Edinburgh; Heather C. Whalley, PhD, Eve C. Johnstone, MD, FRCP, FRCPsych, Stephen M. Lawrie, MD, FRCPE, FRCPsych, David G. C. Owens, MD, FRCP, FRCPsych, Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Division of Psychiatry, The University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037514607"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":4920,"currency":"USD","value_usd":4920},"apc_paid":null,"fwci":1.6923,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.80965625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"208","issue":"6","first_page":"565","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10565","display_name":"Psychopathy, Forensic Psychiatry, Sexual Offending","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.699999988079071},{"id":"https://openalex.org/keywords/longitudinal-brain-changes","display_name":"longitudinal brain changes","score":0.6359999775886536},{"id":"https://openalex.org/keywords/tensor-based-morphometry","display_name":"tensor-based morphometry","score":0.8830000162124634},{"id":"https://openalex.org/keywords/temporal-lobe","display_name":"temporal lobe","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9940000176429749},{"id":"https://openalex.org/keywords/posterior-cingulate-cortex","display_name":"posterior cingulate cortex","score":0.9539999961853027},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.8797224760055542},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7094515562057495},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6364182233810425},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5199159979820251},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.5001876354217529},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4945072829723358},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4665396511554718},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.4558507204055786},{"id":"https://openalex.org/C2778180168","wikidata":"https://www.wikidata.org/wiki/Q815334","display_name":"Parietal lobe","level":2,"score":0.4271267056465149},{"id":"https://openalex.org/C2777132076","wikidata":"https://www.wikidata.org/wiki/Q2560248","display_name":"Sulcus","level":2,"score":0.412354975938797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3996855616569519},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3149595260620117},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2751099467277527},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.25134193897247314},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18974167108535767},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D013702","descriptor_name":"Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1192/bjp.bp.114.154526","doi":"https://doi.org/10.1192/bjp.bp.114.154526","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.114.154526","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/96BA60CA6422B78AC7ABAAD43E6A5418/S0007125000244061a.pdf/div-class-title-negative-symptoms-and-longitudinal-grey-matter-tissue-loss-in-adolescents-at-risk-of-psychosis-preliminary-findings-from-a-6-year-follow-up-study-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:26635326","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26635326","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of psychiatry : the journal of mental science","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/b9cb287f-115b-4444-a43b-8455a349843d","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11820/b9cb287f-115b-4444-a43b-8455a349843d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McKechanie, A, Moorhead, T W J, Stanfield, A C, Whalley, H C, Johnstone, E, Lawrie, S M & Owens, D G C 2016, 'Negative symptoms and longitudinal gray matter tissue loss in adolescents at risk of psychosis : Preliminary findings from a 6-year follow-up study.', British Journal of Psychiatry, vol. 208, no. 6, pp. 565-570. https://doi.org/10.1192/bjp.bp.114.154526","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1192/bjp.bp.114.154526","doi":"https://doi.org/10.1192/bjp.bp.114.154526","is_oa":true,"landing_page_url":"https://doi.org/10.1192/bjp.bp.114.154526","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/96BA60CA6422B78AC7ABAAD43E6A5418/S0007125000244061a.pdf/div-class-title-negative-symptoms-and-longitudinal-grey-matter-tissue-loss-in-adolescents-at-risk-of-psychosis-preliminary-findings-from-a-6-year-follow-up-study-div.pdf","source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8974837567","display_name":null,"funder_award_id":"G0100102","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322134","display_name":"Dr Mortimer and Theresa Sackler Foundation","ror":"https://ror.org/04wpy7706"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2188670720.pdf","grobid_xml":"https://content.openalex.org/works/W2188670720.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W378781361","https://openalex.org/W574023122","https://openalex.org/W610560258","https://openalex.org/W1968190574","https://openalex.org/W1968899037","https://openalex.org/W1981786093","https://openalex.org/W1987282610","https://openalex.org/W1994585255","https://openalex.org/W2003366144","https://openalex.org/W2007298134","https://openalex.org/W2009867055","https://openalex.org/W2014247656","https://openalex.org/W2016335674","https://openalex.org/W2025642716","https://openalex.org/W2037761280","https://openalex.org/W2039396081","https://openalex.org/W2040891448","https://openalex.org/W2041950004","https://openalex.org/W2048517502","https://openalex.org/W2055314969","https://openalex.org/W2059302917","https://openalex.org/W2070877634","https://openalex.org/W2077290709","https://openalex.org/W2081722307","https://openalex.org/W2085157288","https://openalex.org/W2089868642","https://openalex.org/W2095637239","https://openalex.org/W2096486434","https://openalex.org/W2097374894","https://openalex.org/W2105750011","https://openalex.org/W2106040150","https://openalex.org/W2115062882","https://openalex.org/W2123722617","https://openalex.org/W2124405492","https://openalex.org/W2126314048","https://openalex.org/W2127679160","https://openalex.org/W2130928508","https://openalex.org/W2132526271","https://openalex.org/W2133505795","https://openalex.org/W2139977289","https://openalex.org/W2140606211","https://openalex.org/W2141766296","https://openalex.org/W2153572991","https://openalex.org/W2154857655","https://openalex.org/W2159011576","https://openalex.org/W2163097291","https://openalex.org/W2165793012","https://openalex.org/W2171607960","https://openalex.org/W2284323937","https://openalex.org/W2318964658","https://openalex.org/W2470633830","https://openalex.org/W3127623214","https://openalex.org/W6720247385"],"related_works":["https://openalex.org/W2126314048","https://openalex.org/W2091373482","https://openalex.org/W2070877634","https://openalex.org/W2014247656","https://openalex.org/W2044980193","https://openalex.org/W1984173612","https://openalex.org/W3047607638","https://openalex.org/W2077732236","https://openalex.org/W2023274187","https://openalex.org/W2946226628"],"abstract_inverted_index":{"BACKGROUND:":[0],"Negative":[1,131],"symptoms":[2,91,132,149],"are":[3,40,133],"perhaps":[4],"the":[5,50,86,93,107,113,117,120,125],"most":[6],"disabling":[7],"feature":[8],"of":[9,42,52,58,63,100],"schizophrenia.":[10],"Their":[11],"pathogenesis":[12],"remains":[13],"poorly":[14],"understood":[15],"and":[16,71,124],"it":[17],"has":[18],"been":[19],"difficult":[20],"to":[21],"assess":[22],"their":[23],"development":[24,51],"over":[25,106],"time":[26,78],"with":[27,49,88,92,135,147,158],"imaging":[28,36,70],"techniques.":[29],"AIMS:":[30],"To":[31],"examine,":[32],"using":[33,67],"tensor-based":[34,74],"structural":[35],"techniques,":[37],"whether":[38],"there":[39],"regions":[41,99,111,142,155],"progressive":[43],"grey":[44,102,137],"matter":[45,103,138],"volume":[46],"change":[47],"associated":[48,134,146,157],"negative":[53,90,159],"symptoms.":[54,160],"METHOD:":[55],"A":[56],"total":[57],"43":[59],"adolescents":[60],"at":[61,76],"risk":[62],"psychosis":[64],"were":[65],"examined":[66],"magnetic":[68],"resonance":[69],"whole":[72],"brain":[73],"morphometry":[75],"two":[77],"points,":[79],"6":[80],"years":[81],"apart.":[82],"RESULTS:":[83],"When":[84],"comparing":[85],"individuals":[87],"significant":[89,101],"remaining":[94],"participants,":[95],"we":[96],"identified":[97,143],"five":[98],"tissue":[104,139],"loss":[105],"6-year":[108],"period.":[109],"These":[110],"included":[112],"left":[114,118,121,126],"temporal":[115],"lobe,":[116],"cerebellum,":[119],"posterior":[122],"cingulate":[123],"inferior":[127],"parietal":[128],"sulcus.":[129],"CONCLUSIONS:":[130],"longitudinal":[136],"loss.":[140],"The":[141],"include":[144,154],"areas":[145],"psychotic":[148],"more":[150],"generally":[151],"but":[152],"also":[153],"uniquely":[156]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}