{"id":"https://openalex.org/W2188642500","doi":null,"title":"Clinical applications of urinary organic acids. Part I: Detoxification markers.","display_name":"Clinical applications of urinary organic acids. Part I: Detoxification markers.","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2188642500","mag":"2188642500","pmid":"https://pubmed.ncbi.nlm.nih.gov/18950247"},"language":"en","primary_location":{"id":"pmid:18950247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18950247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111866648","display_name":"Richard S. Lord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard S Lord","raw_affiliation_strings":["Metametrix Institute, 3425 Corporate Way, Duluth, Georgia 30096, USA. rslord@metametrix.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metametrix Institute, 3425 Corporate Way, Duluth, Georgia 30096, USA. rslord@metametrix.com","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073221957","display_name":"J. Alexander Bralley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Alexander Bralley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.68,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.62217659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"3","first_page":"205","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.18490000069141388,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.18490000069141388,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.15000000596046448,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-organic-acids","display_name":"urinary organic acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/xylene-exposure","display_name":"xylene exposure","score":0.8040000200271606},{"id":"https://openalex.org/keywords/orotic-acid","display_name":"orotic acid","score":0.9610000252723694},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glucaric-acid","display_name":"glucaric acid","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatic-detoxification","display_name":"hepatic detoxification","score":0.9020000100135803},{"id":"https://openalex.org/keywords/alpha-hydroxybutyrate","display_name":"alpha-hydroxybutyrate","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pyroglutamic-acid","display_name":"pyroglutamic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/sulfate","display_name":"sulfate","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gamma-glutamyl-cycle","display_name":"gamma-glutamyl cycle","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.9224405884742737},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.7838553190231323},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7497240900993347},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.6165803074836731},{"id":"https://openalex.org/C2780473477","wikidata":"https://www.wikidata.org/wiki/Q3072135","display_name":"Toxicant","level":3,"score":0.6088825464248657},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5775109529495239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.572478175163269},{"id":"https://openalex.org/C2775851010","wikidata":"https://www.wikidata.org/wiki/Q425536","display_name":"Orotic acid","level":2,"score":0.5144548416137695},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5127257108688354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4211151599884033},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35952621698379517},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.25870969891548157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2573944926261902},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.18224096298217773},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15405932068824768},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.109459787607193},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07576453685760498},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004785","descriptor_name":"Environmental Pollutants","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005937","descriptor_name":"Glucaric Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006626","descriptor_name":"Hippurates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006885","descriptor_name":"Hydroxybutyrates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009963","descriptor_name":"Orotic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D011761","descriptor_name":"Pyrrolidonecarboxylic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18950247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18950247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.473.2047","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.473.2047","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.altmedrev.com/publications/13/3/205.pdf","raw_type":"text"},{"id":"mag:2188642500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18950247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W79419804","https://openalex.org/W87023947","https://openalex.org/W654444542","https://openalex.org/W1488461445","https://openalex.org/W1565588626","https://openalex.org/W1763772253","https://openalex.org/W1801909240","https://openalex.org/W1972747170","https://openalex.org/W1974103715","https://openalex.org/W1977797146","https://openalex.org/W1980202708","https://openalex.org/W1985478892","https://openalex.org/W1986587950","https://openalex.org/W1996202117","https://openalex.org/W1996379164","https://openalex.org/W1998062378","https://openalex.org/W1999617268","https://openalex.org/W2004151416","https://openalex.org/W2008827161","https://openalex.org/W2011811822","https://openalex.org/W2012976763","https://openalex.org/W2014796076","https://openalex.org/W2016922083","https://openalex.org/W2020470814","https://openalex.org/W2027385354","https://openalex.org/W2027774159","https://openalex.org/W2028000670","https://openalex.org/W2029705686","https://openalex.org/W2031022452","https://openalex.org/W2031379269","https://openalex.org/W2034248880","https://openalex.org/W2038375672","https://openalex.org/W2039180998","https://openalex.org/W2042029123","https://openalex.org/W2046686458","https://openalex.org/W2049525123","https://openalex.org/W2054942847","https://openalex.org/W2067931752","https://openalex.org/W2068894782","https://openalex.org/W2071108051","https://openalex.org/W2071187389","https://openalex.org/W2073655030","https://openalex.org/W2078974726","https://openalex.org/W2079978577","https://openalex.org/W2089716907","https://openalex.org/W2092199071","https://openalex.org/W2095096262","https://openalex.org/W2100500590","https://openalex.org/W2104500690","https://openalex.org/W2111669601","https://openalex.org/W2117936834","https://openalex.org/W2118251588","https://openalex.org/W2135377416","https://openalex.org/W2136892040","https://openalex.org/W2137256259","https://openalex.org/W2138418266","https://openalex.org/W2146190089","https://openalex.org/W2151573711","https://openalex.org/W2153805879","https://openalex.org/W2158275993","https://openalex.org/W2161030602","https://openalex.org/W2162520824","https://openalex.org/W2168174688","https://openalex.org/W2168245898","https://openalex.org/W2256408596","https://openalex.org/W2315491285","https://openalex.org/W2404890488","https://openalex.org/W2412440622","https://openalex.org/W2911288441","https://openalex.org/W3000813216","https://openalex.org/W3171415851"],"related_works":["https://openalex.org/W7098361808","https://openalex.org/W2412365362","https://openalex.org/W3032140916","https://openalex.org/W2156760335","https://openalex.org/W3208866023","https://openalex.org/W2125152315","https://openalex.org/W2123389471","https://openalex.org/W2006665630","https://openalex.org/W2117141998","https://openalex.org/W2022286695"],"abstract_inverted_index":{"Modern":[0],"instrumentation":[1],"allows":[2],"the":[3,17,48,51,87],"measurement":[4],"of":[5,16,37,50,68,72,84,98,113],"organic":[6],"acids":[7],"in":[8,10,86,102],"urine":[9,106],"their":[11],"physiological":[12],"concentration":[13],"ranges.":[14],"Eight":[15],"compounds":[18,64,100],"that":[19,46],"are":[20],"reported":[21],"can":[22,77],"serve":[23],"as":[24],"markers":[25],"for":[26],"specific":[27],"toxicant":[28],"exposure":[29,34],"or":[30,62],"detoxification":[31,56,121],"challenges.":[32],"Xylene":[33],"causes":[35,65],"elevation":[36,42],"2-methylhippurate,":[38],"and":[39,75,90,116],"orotic":[40],"acid":[41],"reveals":[43],"ammonia":[44],"challenge":[45],"exceeds":[47],"capacity":[49],"urea":[52],"cycle.":[53],"General":[54],"hepatic":[55],"stimulation":[57],"by":[58],"natural":[59],"compounds,":[60],"drugs,":[61],"xenobiotic":[63],"elevated":[66],"levels":[67],"glucaric":[69],"acid.":[70],"Abnormalities":[71],"alpha-hydroxybutyrate,":[73],"pyroglutamate,":[74],"sulfate":[76],"indicate":[78],"up-regulated":[79],"glutathione":[80,85,94],"biosynthesis,":[81],"impaired":[82],"reformation":[83],"gamma-glutamyl":[88],"cycle,":[89],"depleted":[91],"total":[92],"body":[93],"status,":[95],"respectively.":[96],"Patterns":[97],"these":[99],"measured":[101],"a":[103],"simple":[104],"overnight":[105],"specimen":[107],"help":[108],"to":[109,120],"identify":[110],"focal":[111],"areas":[112],"clinical":[114],"concern":[115],"monitor":[117],"patient":[118],"responses":[119],"interventions.":[122]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}