{"id":"https://openalex.org/W2188607245","doi":null,"title":"Cajal bodies: where form meets","display_name":"Cajal bodies: where form meets","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2188607245","mag":"2188607245"},"language":"en","primary_location":{"id":"mag:2188607245","doi":null,"is_oa":false,"landing_page_url":"https://publications.mpi-cbg.de/Machyna_2013_5196.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004381413","display_name":"Karla M. Neugebauer","orcid":"https://orcid.org/0000-0002-3835-6761","observed_orcids":["https://orcid.org/0000-0002-3835-6761"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karla M. Neugebauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3835-6761","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004381413"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.17829999327659607,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cajal-bodies","display_name":"Cajal bodies","score":1.0},{"id":"https://openalex.org/keywords/histone-locus-body","display_name":"histone locus bodies","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nuclear-subcompartments","display_name":"nuclear subcompartments","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ribonucleoprotein-assembly","display_name":"ribonucleoprotein assembly","score":0.8799999952316284},{"id":"https://openalex.org/keywords/splicing","display_name":"splicing","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/histone-gene-clusters","display_name":"histone gene clusters","score":0.9160000085830688},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.6055940389633179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5524885654449463},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5503699779510498},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.5295820236206055},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.520438015460968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5152285695075989},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44396787881851196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36160337924957275},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3600509762763977},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.14652344584465027}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188607245","doi":null,"is_oa":false,"landing_page_url":"https://publications.mpi-cbg.de/Machyna_2013_5196.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":147,"referenced_works":["https://openalex.org/W98890672","https://openalex.org/W1561739940","https://openalex.org/W1775357008","https://openalex.org/W1785041454","https://openalex.org/W1965612858","https://openalex.org/W1969521521","https://openalex.org/W1970397315","https://openalex.org/W1973716190","https://openalex.org/W1975756431","https://openalex.org/W1976124466","https://openalex.org/W1976144441","https://openalex.org/W1977757957","https://openalex.org/W1978252332","https://openalex.org/W1979544334","https://openalex.org/W1980071750","https://openalex.org/W1983811755","https://openalex.org/W1985074490","https://openalex.org/W1985717866","https://openalex.org/W1986849895","https://openalex.org/W1991772727","https://openalex.org/W1991934695","https://openalex.org/W1992115941","https://openalex.org/W1993084790","https://openalex.org/W1993717431","https://openalex.org/W1998314264","https://openalex.org/W1999284679","https://openalex.org/W2008430410","https://openalex.org/W2009491803","https://openalex.org/W2010116656","https://openalex.org/W2012674840","https://openalex.org/W2012918968","https://openalex.org/W2014414194","https://openalex.org/W2016410352","https://openalex.org/W2016412991","https://openalex.org/W2019405449","https://openalex.org/W2022687073","https://openalex.org/W2024388361","https://openalex.org/W2025730023","https://openalex.org/W2026226960","https://openalex.org/W2028724790","https://openalex.org/W2033704741","https://openalex.org/W2033925837","https://openalex.org/W2035229948","https://openalex.org/W2039165252","https://openalex.org/W2041912154","https://openalex.org/W2043348864","https://openalex.org/W2043485218","https://openalex.org/W2044774520","https://openalex.org/W2046158811","https://openalex.org/W2047001514","https://openalex.org/W2054352933","https://openalex.org/W2054544162","https://openalex.org/W2054950387","https://openalex.org/W2057400223","https://openalex.org/W2063084749","https://openalex.org/W2063501009","https://openalex.org/W2064808229","https://openalex.org/W2064904514","https://openalex.org/W2066438071","https://openalex.org/W2067382966","https://openalex.org/W2067574987","https://openalex.org/W2069332834","https://openalex.org/W2073324018","https://openalex.org/W2073383145","https://openalex.org/W2079933835","https://openalex.org/W2083260329","https://openalex.org/W2085946431","https://openalex.org/W2089340273","https://openalex.org/W2093230613","https://openalex.org/W2095891777","https://openalex.org/W2096677145","https://openalex.org/W2098735573","https://openalex.org/W2100021370","https://openalex.org/W2100287099","https://openalex.org/W2103504827","https://openalex.org/W2104618420","https://openalex.org/W2104798106","https://openalex.org/W2106830069","https://openalex.org/W2107244138","https://openalex.org/W2107252117","https://openalex.org/W2107318882","https://openalex.org/W2110241873","https://openalex.org/W2111751246","https://openalex.org/W2113768195","https://openalex.org/W2115214832","https://openalex.org/W2116932998","https://openalex.org/W2116949627","https://openalex.org/W2118541199","https://openalex.org/W2119086628","https://openalex.org/W2119799603","https://openalex.org/W2120156669","https://openalex.org/W2123659736","https://openalex.org/W2124469032","https://openalex.org/W2126149754","https://openalex.org/W2126282428","https://openalex.org/W2126294946","https://openalex.org/W2126848848","https://openalex.org/W2126924668","https://openalex.org/W2129992844","https://openalex.org/W2130657959","https://openalex.org/W2130705619","https://openalex.org/W2132239559","https://openalex.org/W2134219069","https://openalex.org/W2134597758","https://openalex.org/W2135212191","https://openalex.org/W2136206093","https://openalex.org/W2136739479","https://openalex.org/W2137681938","https://openalex.org/W2138165292","https://openalex.org/W2139631855","https://openalex.org/W2139979209","https://openalex.org/W2140468006","https://openalex.org/W2142519388","https://openalex.org/W2143079500","https://openalex.org/W2146609854","https://openalex.org/W2146662166","https://openalex.org/W2147106865","https://openalex.org/W2147613443","https://openalex.org/W2147667109","https://openalex.org/W2147973149","https://openalex.org/W2148718900","https://openalex.org/W2148954829","https://openalex.org/W2151535788","https://openalex.org/W2151564350","https://openalex.org/W2152807182","https://openalex.org/W2153465394","https://openalex.org/W2154658130","https://openalex.org/W2154675388","https://openalex.org/W2155080244","https://openalex.org/W2156857490","https://openalex.org/W2158651132","https://openalex.org/W2160130765","https://openalex.org/W2160376475","https://openalex.org/W2161748099","https://openalex.org/W2162949504","https://openalex.org/W2163527903","https://openalex.org/W2163719299","https://openalex.org/W2164975614","https://openalex.org/W2165314700","https://openalex.org/W2166176887","https://openalex.org/W2166885155","https://openalex.org/W2167356244","https://openalex.org/W2167939720","https://openalex.org/W2170886452","https://openalex.org/W2171338385","https://openalex.org/W2334290187","https://openalex.org/W4299090206"],"related_works":["https://openalex.org/W2038272359","https://openalex.org/W1572855035","https://openalex.org/W2104746705","https://openalex.org/W2522621368","https://openalex.org/W2529038719","https://openalex.org/W2016412991","https://openalex.org/W4230931131","https://openalex.org/W2107252117","https://openalex.org/W2161902637","https://openalex.org/W2613412925"],"abstract_inverted_index":{"The":[0],"cell":[1],"nucleus":[2],"contains":[3],"dozens":[4],"of":[5,36,98,105,112,116,163,168,184],"subcompartments":[6],"that":[7],"separate":[8],"biochemical":[9],"processes":[10],"into":[11,174],"confined":[12],"spaces.":[13],"Cajal":[14],"bodies":[15],"(CBs)":[16],"were":[17],"discovered":[18],"more":[19],"than":[20],"100":[21],"years":[22],"ago,":[23],"but":[24],"only":[25],"extensive":[26],"research":[27],"in":[28,43,60,81,128,135,144],"the":[29,33,96],"past":[30],"decades":[31],"revealed":[32],"surprising":[34],"complexity":[35],"molecular":[37],"and":[38,53,64],"cellular":[39],"functions":[40],"taking":[41],"place":[42,52],"these":[44,109],"structures.ManyproteinandRNAspeciesaremodifiedandassembledwithinCBs,":[45],"which":[46,129],"have":[47],"emerged":[48],"as":[49,180],"a":[50,68,103,132,151,166,181],"meeting":[51],"factory":[54],"for":[55,154],"ribonucleoprotein":[56],"(RNP)":[57],"particles":[58],"involved":[59],"splicing,":[61],"ribosome":[62],"biogenesis":[63],"telomere":[65],"maintenance.":[66],"Recently,":[67],"distinct":[69,99],"structure":[70],"near":[71],"histone":[72,82],"gene":[73],"clusters\u2014the":[74],"Histone":[75],"locus":[76],"body":[77,155],"(HLB)\u2014was":[78],"discovered.":[79],"Involved":[80],"mRNA":[83],"3":[84],"\ufffd":[85],"-end":[86],"formation,":[87],"HLBs":[88,100],"can":[89,171],"share":[90,124],"several":[91],"components":[92,142],"with":[93],"CBs.":[94,176],"Whether":[95],"appearance":[97],"is":[101,119],"simply":[102],"matter":[104],"altered":[106],"affinity":[107],"between":[108],"structures":[110,123],"or":[111],"an":[113,160],"alternate":[114],"mode":[115],"CB":[117,157,185],"assembly":[118,126,158],"unknown.":[120],"However,":[121],"both":[122],"basic":[125],"properties,":[127],"transcription":[130],"plays":[131],"decisive":[133],"role":[134],"initiation.":[136],"After":[137],"this":[138,179],"seeding":[139],"event,":[140],"additional":[141,161],"associate":[143],"random":[145],"order.":[146],"This":[147],"appears":[148],"to":[149],"be":[150,172],"widespread":[152],"mechanism":[153],"assembly.":[156,186],"encompasses":[159],"layer":[162],"complexity,":[164],"whereby":[165],"set":[167],"pre-existing":[169],"substructures":[170],"integrated":[173],"mature":[175],"We":[177],"propose":[178],"multi-seeding":[182],"model":[183],"\u00a9":[187],"2012":[188],"John":[189],"Wiley":[190],"&":[191],"Sons,":[192],"Ltd.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}