{"id":"https://openalex.org/W2188573532","doi":null,"title":"Effects of Omega-3 Fatty Acids on Pentylenetetrazole-induced Kindling, Cognitive Impairment and Oxidative Stress","display_name":"Effects of Omega-3 Fatty Acids on Pentylenetetrazole-induced Kindling, Cognitive Impairment and Oxidative Stress","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2188573532","mag":"2188573532"},"language":"en","primary_location":{"id":"mag:2188573532","doi":null,"is_oa":false,"landing_page_url":"http://www.lifesciencesite.com/lsj/life1107/023_20812life110714_186_196.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029640435","display_name":"Basel A. Abdel\u2010Wahab","orcid":"https://orcid.org/0000-0002-5545-6422","observed_orcids":["https://orcid.org/0000-0002-5545-6422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Basel A. Abdel\u2010Wahab","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5545-6422","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011857692","display_name":"Samy M. Abd El-Aziz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samy M. Abd El-Aziz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067759743","display_name":"Jobran Miree Alqahtani","orcid":"https://orcid.org/0000-0003-3198-7576","observed_orcids":["https://orcid.org/0000-0003-3198-7576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jobran Miree Alqahtani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3198-7576","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":1.0},{"id":"https://openalex.org/keywords/pentylenetetrazole-kindling","display_name":"pentylenetetrazole kindling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9610000252723694},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.5799999833106995},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.8076049089431763},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7950267791748047},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7745822668075562},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6554473638534546},{"id":"https://openalex.org/C2778302826","wikidata":"https://www.wikidata.org/wiki/Q1741970","display_name":"Kindling model","level":4,"score":0.5485754609107971},{"id":"https://openalex.org/C2910982124","wikidata":"https://www.wikidata.org/wiki/Q116275","display_name":"Myoclonic Jerk","level":3,"score":0.5412532687187195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5020911693572998},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.4970591366291046},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4545130729675293},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.4399895966053009},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4270942807197571},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4225365221500397},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37289655208587646},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33466291427612305},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3217132091522217},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3156887888908386},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.22882375121116638},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0645151138305664}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188573532","doi":null,"is_oa":false,"landing_page_url":"http://www.lifesciencesite.com/lsj/life1107/023_20812life110714_186_196.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W131227425","https://openalex.org/W1588850953","https://openalex.org/W1775749144","https://openalex.org/W1963651433","https://openalex.org/W1971048984","https://openalex.org/W1972506687","https://openalex.org/W1974240184","https://openalex.org/W1983310681","https://openalex.org/W1985298279","https://openalex.org/W1986787732","https://openalex.org/W1988424596","https://openalex.org/W2000090237","https://openalex.org/W2000450514","https://openalex.org/W2002265349","https://openalex.org/W2003682910","https://openalex.org/W2015959472","https://openalex.org/W2016852080","https://openalex.org/W2025583462","https://openalex.org/W2026884092","https://openalex.org/W2034303125","https://openalex.org/W2037094028","https://openalex.org/W2038445303","https://openalex.org/W2043742955","https://openalex.org/W2046605966","https://openalex.org/W2048661776","https://openalex.org/W2049617752","https://openalex.org/W2051633111","https://openalex.org/W2056980068","https://openalex.org/W2064002289","https://openalex.org/W2068888734","https://openalex.org/W2069124726","https://openalex.org/W2077823488","https://openalex.org/W2082573840","https://openalex.org/W2085373530","https://openalex.org/W2089216473","https://openalex.org/W2091079457","https://openalex.org/W2093440221","https://openalex.org/W2100774655","https://openalex.org/W2101518804","https://openalex.org/W2105023289","https://openalex.org/W2118519973","https://openalex.org/W2121787306","https://openalex.org/W2130081367","https://openalex.org/W2135782620","https://openalex.org/W2138676964","https://openalex.org/W2142988812","https://openalex.org/W2157340973","https://openalex.org/W2168480206"],"related_works":["https://openalex.org/W1973180642","https://openalex.org/W2027044540","https://openalex.org/W2060956504","https://openalex.org/W2127709419","https://openalex.org/W2071965500","https://openalex.org/W3008859527","https://openalex.org/W7135427488","https://openalex.org/W4408381467","https://openalex.org/W7124957102","https://openalex.org/W2580152434"],"abstract_inverted_index":{"Epilepsy":[0],"as":[1,3,157,159,229,238,240],"well":[2,158,239],"chronic":[4],"use":[5],"of":[6,58,68,75,93,167,227,260],"most":[7],"antiepileptic":[8],"drugs,":[9],"particularly":[10],"in":[11,44,85,120,137,187,201,217,232],"children,":[12],"predisposes":[13],"to":[14,23,63,152,235,241],"cognitive":[15,48,71,107,178,209],"impairment.":[16,247],"The":[17,56,91],"brain":[18],"is":[19],"considered":[20],"abnormally":[21],"sensitive":[22],"oxidative":[24,79,114,175,211],"stress":[25,80,176,212],"and":[26,52,77,81,99,163,177,213,255,269],"damage":[27,84,216],"which":[28,180],"observed":[29],"during":[30],"seizure":[31,244],"activity.":[32],"Omega-3":[33,261],"(OM3)":[34],"fatty":[35],"acids":[36],"are":[37],"known":[38],"antioxidants":[39],"that":[40],"play":[41],"a":[42,173,188],"role":[43],"nervous":[45],"system":[46],"activity,":[47],"development,":[49],"memory-related":[50],"learning,":[51],"synaptic":[53],"transmission.":[54],"Aim:":[55],"aim":[57],"the":[59,65,117,150,165,225],"present":[60],"study":[61],"was":[62,181],"investigate":[64],"protective":[66],"effects":[67],"OM3":[69,96,142,147,186,200,206,228],"on":[70,103,264],"impairment":[72,179],"after":[73,139],"development":[74],"seizures":[76,156,237],"corresponding":[78,106,118],"neuronal":[82],"DNA":[83,215],"young":[86],"pentylenetetrazole":[87],"(PTZ)-kindled":[88],"rats.":[89,204,220],"Methods:":[90],"effect":[92],"pretreatment":[94,184],"with":[95,185],"(200,":[97],"300":[98],"500":[100],"mg/kg,":[101,129],"orally)":[102],"PTZ-induced":[104],"kindling,":[105],"impairment,":[108,210],"using":[109],"passive":[110],"avoidance":[111],"test,":[112],"hippocampal":[113,121,193,214],"stress.":[115],"Furthermore,":[116],"changes":[119],"8-hydroxy-2'-deoxyguanosine":[122],"(8-OHdG)":[123],"were":[124,196],"measured.":[125],"Results:":[126],"PTZ,":[127],"(30":[128],"i.p.)":[130],"once":[131],"every":[132],"alternate":[133],"day":[134],"induced":[135,172,245],"kindling":[136,171],"rats":[138],"31.0\u00b11.4":[140],"days.":[141],"showed":[143],"dose-dependent":[144,189],"anti-seizure":[145],"effect.":[146],"significantly":[148,197],"increased":[149],"latency":[151],"myoclonic":[153,168],"jerks,":[154],"clonic":[155],"generalized":[160],"tonic-clonic":[161],"seizures,":[162,208],"decreased":[164],"number":[166],"jerks.":[169],"PTZ":[170,202,218],"significant":[174],"reversed":[182],"by":[183,199],"manner.":[190],"In":[191],"addition,":[192],"8-OHdG":[194],"levels":[195],"reduced":[198],"kindled":[203,219],"Conclusions:":[205],"ameliorates":[207],"These":[221],"results":[222],"thus":[223],"suggest":[224],"potential":[226],"an":[230],"adjuvant":[231],"epilepsy":[233],"both":[234],"prevent":[236],"protect":[242],"against":[243],"memory":[246],"(Basel":[248],"A.":[249],"Abdel-Wahab,":[250],"Samy":[251],"M.":[252,257],"Abd":[253],"El-Aziz,":[254],"Jobran":[256],"Al-Qahtani.":[258],"Effects":[259],"Fatty":[262],"Acids":[263],"Pentylenetetrazole-induced":[265],"Kindling,":[266],"Cognitive":[267],"Impairment":[268],"Oxidative":[270],"Stress.":[271],"Life":[272],"Sci":[273],"J":[274],"2014;11(7):186-":[275],"196).":[276],"(ISSN:1097-8135).":[277],"http://www.lifesciencesite.com":[278],".":[279],"23":[280]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}