{"id":"https://openalex.org/W2188552968","doi":null,"title":"Immunohistochemical TRF1 expression in human primary intracranial tumors.","display_name":"Immunohistochemical TRF1 expression in human primary intracranial tumors.","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2188552968","mag":"2188552968","pmid":"https://pubmed.ncbi.nlm.nih.gov/11501837"},"language":"en","primary_location":{"id":"pmid:11501837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035081463","display_name":"Marcello Aragona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Aragona","raw_affiliation_strings":["Operative Unit of Medical Oncology, University of Messina, School of Medicine, Italy. marcello.aragona@unime.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Operative Unit of Medical Oncology, University of Messina, School of Medicine, Italy. marcello.aragona@unime.it","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066478061","display_name":"Oreste DE DIVITIIS","orcid":"https://orcid.org/0000-0001-7265-5418","observed_orcids":["https://orcid.org/0000-0001-7265-5418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O De Divitiis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001936227","display_name":"Domenico La Torre","orcid":"https://orcid.org/0000-0002-3918-8798","observed_orcids":["https://orcid.org/0000-0002-3918-8798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D La Torre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108949153","display_name":"S Panetta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Panetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065260097","display_name":"Domenico D\u2019Avella","orcid":"https://orcid.org/0000-0001-9077-412X","observed_orcids":["https://orcid.org/0000-0001-9077-412X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D D'Avella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079334543","display_name":"Antonio Pontoriero","orcid":"https://orcid.org/0000-0003-3011-6779","observed_orcids":["https://orcid.org/0000-0003-3011-6779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pontoriero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059011370","display_name":"Moran Morelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Morelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064895172","display_name":"Ignazia La Torre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I La Torre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048428897","display_name":"Francesco F. Tomasello","orcid":"https://orcid.org/0000-0003-1435-3598","observed_orcids":["https://orcid.org/0000-0003-1435-3598"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Tomasello","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1511,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.38738345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"3C","first_page":"2135","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.8744999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.061799999326467514,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trf1","display_name":"TRF1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/intracranial-tumors","display_name":"intracranial tumors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.984000027179718},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.8579999804496765},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.8471514582633972},{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.615321934223175},{"id":"https://openalex.org/C2779160599","wikidata":"https://www.wikidata.org/wiki/Q369157","display_name":"Meningioma","level":2,"score":0.6023368835449219},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5996163487434387},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.5134004354476929},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.47228604555130005},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.39853718876838684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38582563400268555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3542637825012207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.267799973487854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035321","descriptor_name":"Telomeric Repeat Binding Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:11501837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/402069","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11770/402069","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/142469","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/142469","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2188552968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1522255857","https://openalex.org/W1546643851","https://openalex.org/W1621602741","https://openalex.org/W1967135627","https://openalex.org/W1970825472","https://openalex.org/W1972214118","https://openalex.org/W1976273464","https://openalex.org/W1989113088","https://openalex.org/W1990786155","https://openalex.org/W1993647406","https://openalex.org/W2000971601","https://openalex.org/W2013073993","https://openalex.org/W2015752274","https://openalex.org/W2024619097","https://openalex.org/W2027779909","https://openalex.org/W2036870311","https://openalex.org/W2042221269","https://openalex.org/W2050674095","https://openalex.org/W2062706487","https://openalex.org/W2075808770","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2112671059","https://openalex.org/W2123105653","https://openalex.org/W2126224474","https://openalex.org/W2158958280","https://openalex.org/W2399884073"],"related_works":["https://openalex.org/W7217384631","https://openalex.org/W7047279936","https://openalex.org/W2122533204","https://openalex.org/W2162925203","https://openalex.org/W2042221269","https://openalex.org/W2384274813","https://openalex.org/W2390636058","https://openalex.org/W2982460103","https://openalex.org/W2063604366","https://openalex.org/W2080323533"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"telomeric-repeat":[2],"binding":[3],"factor":[4],"(TRF1)":[5],"participates":[6],"in":[7,24,31,45,72,89,137,144,148,162],"a":[8,49],"physiological":[9],"homeostatic":[10],"mechanism":[11],"controlling":[12],"telomere":[13,25],"shortening":[14],"by":[15,42],"inhibiting":[16],"telomerase":[17],"activity:":[18],"down-regulation":[19],"of":[20,51,69,75,87,133,167],"TRF1":[21,40,70,88,100,135,160],"expression":[22,41,71,86,136],"results":[23],"elongation":[26],"and":[27,59,109],"may":[28],"be":[29],"involved":[30],"cell":[32],"immortalization.":[33],"PATIENTS":[34],"AND":[35],"METHODS:":[36],"To":[37],"determine":[38],"the":[39,76,124,159],"immunohistochemistry":[43],"(IHC)":[44],"human":[46],"brain":[47],"tumors,":[48,139],"cohort":[50],"20":[52],"consecutive":[53],"flash-frozen":[54],"surgical":[55],"specimens":[56],"(14":[57],"meningiomas":[58],"6":[60],"anaplastic":[61],"astrocytomas":[62],"(AA))":[63],"were":[64,81,102],"collected.":[65],"RESULTS:":[66],"Variable":[67],"levels":[68],"12":[73],"out":[74],"14":[77],"(87.5%)":[78],"meningioma":[79],"samples":[80,91],"observed.":[82],"By":[83],"contrast,":[84],"no":[85],"tissue":[90],"from":[92,156],"AA":[93],"(p":[94],"=":[95,116],"0.008)":[96],"was":[97],"detected.":[98],"Positive":[99],"cells":[101],"usually":[103],"more":[104],"differentiated":[105],"(less":[106],"atypical":[107],"features)":[108],"Ki67":[110],"negative":[111],"(inverse":[112],"statistical":[113],"association,":[114],"chi2":[115],"p":[117],"<":[118],"0.001).":[119],"CONCLUSION:":[120],"We":[121],"demonstrated,":[122],"for":[123],"first":[125],"time,":[126],"that":[127],"routine":[128],"IHC":[129],"techniques":[130],"are":[131],"capable":[132],"identifying":[134],"intracranial":[138,163],"which":[140],"is":[141],"heterogeneously":[142],"expressed":[143],"meningiomas,":[145],"but":[146],"absent":[147],"AA.":[149],"Although":[150],"these":[151],"preliminary":[152],"observations":[153],"need":[154],"confirmation":[155],"larger":[157],"studies,":[158],"status":[161],"tumors":[164],"might":[165],"become":[166],"prognostic":[168],"value.":[169]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}