{"id":"https://openalex.org/W2188534493","doi":null,"title":"CD4+CD25+ T regulatory cells and MMP-9 as diagnostic salivary biomarkers in oral lichen planus.","display_name":"CD4+CD25+ T regulatory cells and MMP-9 as diagnostic salivary biomarkers in oral lichen planus.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2188534493","mag":"2188534493","pmid":"https://pubmed.ncbi.nlm.nih.gov/24617046"},"language":"en","primary_location":{"id":"pmid:24617046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24617046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian journal of immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037815140","display_name":"Marwa Fathi","orcid":"https://orcid.org/0000-0003-2182-8045","observed_orcids":["https://orcid.org/0000-0003-2182-8045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marwa S Fathi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043177545","display_name":"Hadir F. El-Dessouky","orcid":"https://orcid.org/0009-0005-0240-3430","observed_orcids":["https://orcid.org/0009-0005-0240-3430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hadir F El Dessouky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009601354","display_name":"Hind A Breni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hind A Breni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2281,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76151471,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"2","first_page":"39","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13761","display_name":"HIV/AIDS oral health manifestations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-lichen-planus","display_name":"oral lichen planus","score":1.0},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9779999852180481},{"id":"https://openalex.org/keywords/salivary-biomarkers","display_name":"salivary biomarkers","score":0.9980000257492065},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.4830000102519989},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/keratinocyte-apoptosis","display_name":"keratinocyte apoptosis","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2776201145","wikidata":"https://www.wikidata.org/wiki/Q848371","display_name":"Oral lichen planus","level":2,"score":0.8017938137054443},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.6510017514228821},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4681952893733978},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.4528130888938904},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4516696631908417},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43345680832862854},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.43203532695770264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41373759508132935},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.41139256954193115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34719789028167725},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2957385778427124},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2307223379611969},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16288071870803833},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10167241096496582}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017676","descriptor_name":"Lichen Planus, Oral","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017676","descriptor_name":"Lichen Planus, Oral","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017676","descriptor_name":"Lichen Planus, Oral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24617046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24617046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Egyptian journal of immunology","raw_type":"Journal Article"},{"id":"mag:2188534493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24617046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W116164095","https://openalex.org/W155671306","https://openalex.org/W1570550421","https://openalex.org/W1573184070","https://openalex.org/W1602567052","https://openalex.org/W1965022159","https://openalex.org/W1965493434","https://openalex.org/W1970856757","https://openalex.org/W1972932426","https://openalex.org/W1980453617","https://openalex.org/W1982566467","https://openalex.org/W1985556897","https://openalex.org/W1990662369","https://openalex.org/W2002382793","https://openalex.org/W2005686804","https://openalex.org/W2016307162","https://openalex.org/W2024140061","https://openalex.org/W2036919458","https://openalex.org/W2043769665","https://openalex.org/W2073476479","https://openalex.org/W2079051457","https://openalex.org/W2084107384","https://openalex.org/W2085536688","https://openalex.org/W2086812919","https://openalex.org/W2095197048","https://openalex.org/W2104426891","https://openalex.org/W2112373844","https://openalex.org/W2121724904","https://openalex.org/W2129292816","https://openalex.org/W2141005037","https://openalex.org/W2151144438","https://openalex.org/W2163879051","https://openalex.org/W2171682492","https://openalex.org/W2678416410","https://openalex.org/W2792745638"],"related_works":["https://openalex.org/W2102788829","https://openalex.org/W2054181973","https://openalex.org/W2953424846","https://openalex.org/W2159090765","https://openalex.org/W4414924635","https://openalex.org/W4293124486","https://openalex.org/W2341871081","https://openalex.org/W2991435913","https://openalex.org/W3182358599","https://openalex.org/W4413758951"],"abstract_inverted_index":{"Oral":[0],"lichen":[1],"planus":[2],"(OLP)":[3],"is":[4],"a":[5,11,176],"chronic":[6],"inflammatory":[7],"disease":[8],"characterized":[9],"by":[10,133,138,152],"dense":[12],"subepithelial":[13],"lymphocytic":[14],"infiltrate,":[15],"degeneration":[16],"of":[17,64,79,101,128,143,166,206],"basal":[18],"keratinocytes":[19],"and":[20,30,57,113,124,135,160,190,197],"basement":[21,51],"membrane":[22,52],"disruption.":[23],"Non-specific":[24],"mechanisms":[25,39],"include":[26],"mast":[27],"cell":[28],"degranulation":[29],"matrix":[31],"metalloproteinase":[32],"(MMP)":[33],"activation":[34],"in":[35,46,60,92,150,170,179,203],"OLP":[36,102],"lesions.":[37],"These":[38],"may":[40,67],"combine":[41],"to":[42,69],"cause":[43],"T-cell":[44,55],"accumulation":[45],"the":[47,77,144,204],"superficial":[48],"lamina":[49],"propria,":[50],"disruption,":[53],"intra-epithelial":[54],"migration,":[56],"keratinocyte":[58],"apoptosis":[59],"OLP.":[61,95,207],"Obviously,":[62],"abnormality":[63],"immunological":[65],"regulation":[66],"contribute":[68],"its":[70],"pathogenesis.":[71],"This":[72],"study":[73],"aimed":[74],"at":[75],"evaluating":[76],"role":[78],"salivary":[80,90,129,167,186],"CD4+CD25+":[81,148,171,180,187],"T":[82,130,188],"regulatory":[83,131],"cells":[84,132],"&":[85,200],"Matrix":[86],"Metalloproteinase-9":[87],"(MMP.9)":[88],"as":[89,195],"biomarkers":[91,202],"patients":[93,97,146],"with":[94,98,106,111,115,155],"Twenty":[96],"various":[99],"forms":[100],"were":[103],"investigated:":[104],"8":[105],"bullous":[107],"erosive":[108],"form,":[109],"7":[110],"atrophic":[112],"5":[114],"reticular":[116],"forms.":[117],"From":[118],"each":[119],"patient":[120],"saliva":[121,151],"was":[122],"collected,":[123],"used":[125],"for":[126],"assessment":[127],"immunoflourescent":[134,153],"MMP9":[136],"expression":[137],"quantitative":[139],"RT-PCR.":[140],"Nine":[141],"out":[142],"twenty":[145],"showed":[147,175],"Tregs":[149,172,181],"staining":[154],"sensitivity":[156],"(90%),":[157],"specificity":[158],"(83.3%)":[159],"diagnostic":[161,199],"accuracy":[162],"(87.5%).":[163],"molecular":[164],"detection":[165,205],"MMP-9":[168,191],"levels":[169],"+ve":[173,182],"cases":[174],"significant":[177],"increase":[178],"cases.":[183],"In":[184],"conclusion,":[185],"regs":[189],"could":[192],"be":[193],"considered":[194],"sensitive":[196],"specific":[198],"prognostic":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}