{"id":"https://openalex.org/W2188527201","doi":"https://doi.org/10.1158/1078-0432.ccr-15-0143","title":"A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome","display_name":"A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome","publication_year":2015,"publication_date":"2015-10-07","ids":{"openalex":"https://openalex.org/W2188527201","doi":"https://doi.org/10.1158/1078-0432.ccr-15-0143","mag":"2188527201","pmid":"https://pubmed.ncbi.nlm.nih.gov/26446941","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4802496"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-15-0143","doi":"https://doi.org/10.1158/1078-0432.ccr-15-0143","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-15-0143","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4802496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055925608","display_name":"Michael J. Schell","orcid":"https://orcid.org/0000-0003-4594-6601","observed_orcids":["https://orcid.org/0000-0003-4594-6601"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael J. Schell","raw_affiliation_strings":["1Moffitt Cancer Center & Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center & Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002006406","display_name":"Mingli Yang","orcid":"https://orcid.org/0000-0002-4781-690X","observed_orcids":["https://orcid.org/0000-0002-4781-690X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingli Yang","raw_affiliation_strings":["2Gibbs Cancer Center & Research Institute, Spartanburg, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Gibbs Cancer Center & Research Institute, Spartanburg, South Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051590155","display_name":"Edoardo Missiaglia","orcid":"https://orcid.org/0000-0001-9221-0117","observed_orcids":["https://orcid.org/0000-0001-9221-0117"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Edoardo Missiaglia","raw_affiliation_strings":["3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078722669","display_name":"Mauro Delorenzi","orcid":"https://orcid.org/0000-0001-7631-3263","observed_orcids":["https://orcid.org/0000-0001-7631-3263"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mauro Delorenzi","raw_affiliation_strings":["3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland","4Ludwig Center for Cancer Research, University of Lausanne (CH), Lausanne, Switzerland","5Department of Oncology, University of Lausanne (CH), Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"4Ludwig Center for Cancer Research, University of Lausanne (CH), Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"5Department of Oncology, University of Lausanne (CH), Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008885844","display_name":"Charlotte Soneson","orcid":"https://orcid.org/0000-0003-3833-2169","observed_orcids":["https://orcid.org/0000-0003-3833-2169"]},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Charlotte Soneson","raw_affiliation_strings":["3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014436324","display_name":"Binglin Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binglin Yue","raw_affiliation_strings":["1Moffitt Cancer Center & Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center & Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054654521","display_name":"Michael Nebozhyn","orcid":"https://orcid.org/0000-0001-8835-7714","observed_orcids":["https://orcid.org/0000-0001-8835-7714"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael V. Nebozhyn","raw_affiliation_strings":["6Merck, Sharp and Dohme, West Point, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Merck, Sharp and Dohme, West Point, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060841115","display_name":"Andrey P. Loboda","orcid":"https://orcid.org/0000-0003-4239-184X","observed_orcids":["https://orcid.org/0000-0003-4239-184X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey Loboda","raw_affiliation_strings":["6Merck, Sharp and Dohme, West Point, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Merck, Sharp and Dohme, West Point, Pennsylvania","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026325794","display_name":"Gregory C. Bloom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Bloom","raw_affiliation_strings":["1Moffitt Cancer Center & Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Moffitt Cancer Center & Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113849367","display_name":"Timothy Joseph Yeatman","orcid":"https://orcid.org/0000-0002-7487-0784","observed_orcids":["https://orcid.org/0000-0002-7487-0784"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Timothy J. Yeatman","raw_affiliation_strings":["2Gibbs Cancer Center & Research Institute, Spartanburg, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Gibbs Cancer Center & Research Institute, Spartanburg, South Carolina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055925608","https://openalex.org/A5113849367"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":1.7982,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86202384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"3","first_page":"734","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.23579999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metastasis-prediction","display_name":"metastasis prediction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.890999972820282},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9750000238418579},{"id":"https://openalex.org/keywords/stage-iii-colorectal-cancer","display_name":"stage III colorectal cancer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7309340238571167},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.6825054883956909},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6548250913619995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.617630660533905},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6172921061515808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6106030941009521},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.555482804775238},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.5160731673240662},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5159919261932373},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4462507963180542},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3245721459388733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22443506121635437},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22379472851753235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.179146409034729},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.07148131728172302},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058750","descriptor_name":"Epithelial-Mesenchymal Transition","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063868","descriptor_name":"Patient Outcome Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1158/1078-0432.ccr-15-0143","doi":"https://doi.org/10.1158/1078-0432.ccr-15-0143","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-15-0143","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:26446941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26446941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4145628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4802496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4802496","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4802496/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:iris.unil.ch:iris/254544","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/254544","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_EA19DDA38B3B","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_EA19DDA38B3B","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research : An Official Journal of the American Association For Cancer Research, vol. 22, no. 3, pp. 734-745","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4145628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4802496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5507088327","display_name":"INDIVIDUALIZING COLON CANCER THERAPY USING HYBRID RNA AND DNA MOLECULAR SIGNATURE","funder_award_id":"U01CA157960","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1546952499","https://openalex.org/W1971226311","https://openalex.org/W1975760666","https://openalex.org/W1976559597","https://openalex.org/W1980768574","https://openalex.org/W1983107759","https://openalex.org/W1998558839","https://openalex.org/W2002697796","https://openalex.org/W2015707566","https://openalex.org/W2021910662","https://openalex.org/W2022577155","https://openalex.org/W2023560061","https://openalex.org/W2023906705","https://openalex.org/W2033533336","https://openalex.org/W2033751993","https://openalex.org/W2035422738","https://openalex.org/W2038143310","https://openalex.org/W2042883111","https://openalex.org/W2056766497","https://openalex.org/W2071732560","https://openalex.org/W2080232352","https://openalex.org/W2085963386","https://openalex.org/W2088035579","https://openalex.org/W2093036951","https://openalex.org/W2095144222","https://openalex.org/W2097642044","https://openalex.org/W2105829583","https://openalex.org/W2108516575","https://openalex.org/W2113088269","https://openalex.org/W2116200229","https://openalex.org/W2118017554","https://openalex.org/W2124402963","https://openalex.org/W2128445526","https://openalex.org/W2128502368","https://openalex.org/W2144026118","https://openalex.org/W2154941270","https://openalex.org/W2155348198","https://openalex.org/W2155756738","https://openalex.org/W2162035544","https://openalex.org/W2164358503","https://openalex.org/W2165286055","https://openalex.org/W2166842799","https://openalex.org/W2168887286","https://openalex.org/W2170468505","https://openalex.org/W2262414037"],"related_works":["https://openalex.org/W3133596332","https://openalex.org/W3136311981","https://openalex.org/W3107755801","https://openalex.org/W2867257617","https://openalex.org/W3028106501","https://openalex.org/W4210492167","https://openalex.org/W3169665724","https://openalex.org/W4288010145","https://openalex.org/W3199925922","https://openalex.org/W2591217152"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1],"previously":[2],"found":[3,99],"that":[4],"an":[5,160],"epithelial-to-mesenchymal":[6],"transition":[7],"(EMT)-based":[8],"gene":[9],"expression":[10],"signature":[11,73,79,207,241],"was":[12,27,31,83,98,191,208,220],"highly":[13],"correlated":[14,77,209],"with":[15,90,142,211,216,229,243],"the":[16,71,149,206],"first":[17],"principal":[18],"component":[19],"(PC1)":[20],"of":[21,40,48,93,105,189,223],"326":[22],"colorectal":[23,50],"cancer":[24,51,252],"tumors":[25,52,141],"and":[26,42,57,107,125,263],"prognostic.":[28],"This":[29],"study":[30,237],"designed":[32],"to":[33,62,100,119,134,193,196,246,260],"improve":[34],"these":[35],"signatures":[36],"for":[37,164],"better":[38],"prediction":[39],"metastasis":[41,106,262],"outcome.":[43],"EXPERIMENTAL":[44],"DESIGN:":[45],"A":[46],"total":[47,92],"468":[49],"including":[53,250],"all":[54],"stages":[55,117],"(I-IV)":[56],"metastatic":[58,137],"lesions":[59],"were":[60],"used":[61],"develop":[63],"a":[64,91,131,143,221,239,244],"new":[65],"prognostic":[66,225,233,240],"score":[67,74,82,226,242],"(\u0394PC1.EMT)":[68],"by":[69,170],"subtracting":[70],"EMT":[72],"from":[75],"its":[76,110,194,258],"PC1":[78],"score.":[80],"The":[81,186,236],"validated":[84],"on":[85],"six":[86],"other":[87,231],"independent":[88],"datasets":[89],"3,697":[94],"tumors.":[95],"RESULTS:":[96],"\u0394PC1.EMT":[97,190,219],"be":[101],"far":[102],"more":[103],"predictive":[104],"outcome":[108,265],"than":[109],"parent":[111],"scores.":[112],"It":[113],"performed":[114],"well":[115,201],"in":[116,140,148,159,266],"I":[118],"III,":[120],"among":[121],"microsatellite":[122],"instability":[123],"subtypes,":[124],"across":[126],"multiple":[127],"mutation-based":[128],"subclasses,":[129],"demonstrating":[130],"refined":[132],"capacity":[133],"predict":[135,261],"distant":[136],"potential":[138,259],"even":[139],"\"good\"":[144],"prognosis.":[145],"For":[146],"example,":[147],"PETACC-3":[150],"clinical":[151],"trial":[152],"dataset,":[153],"it":[154],"predicted":[155],"worse":[156],"overall":[157],"survival":[158],"adjusted":[161],"multivariable":[162],"model":[163],"stage":[165,267],"III":[166],"patients":[167],"(HR":[168],"standardized":[169],"interquartile":[171],"range":[172],"[IQR]":[173],"=":[174,181,184],"1.50;":[175],"95%":[176],"confidence":[177],"interval,":[178],"1.25-1.81;":[179],"P":[180],"0.000016,":[182],"N":[183],"644).":[185],"improved":[187],"performance":[188],"related":[192],"propensity":[195,245],"identify":[197],"epithelial-like":[198],"subpopulations":[199],"as":[200,202],"mesenchymal-like":[203],"subpopulations.":[204],"Biologically,":[205],"positively":[210],"RAS":[212],"signaling":[213],"but":[214],"negatively":[215],"mitochondrial":[217],"metabolism.":[218],"\"best":[222],"assessed\"":[224],"when":[227],"compared":[228],"10":[230],"known":[232],"signatures.":[234],"CONCLUSIONS:":[235],"developed":[238],"detect":[247],"non-EMT":[248],"features,":[249],"epithelial":[251],"stem":[253],"cell-related":[254],"properties,":[255],"thereby":[256],"improving":[257],"poorer":[264],"I-III":[268],"patients.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}