{"id":"https://openalex.org/W2188474471","doi":null,"title":"Derivation of pluripotent stem cells from cultured human primordial germ cells (alkaline phosphataseyembryoid bodyyembryonic stem cellyembryonic germ cell)","display_name":"Derivation of pluripotent stem cells from cultured human primordial germ cells (alkaline phosphataseyembryoid bodyyembryonic stem cellyembryonic germ cell)","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2188474471","mag":"2188474471"},"language":"en","primary_location":{"id":"mag:2188474471","doi":null,"is_oa":false,"landing_page_url":"http://ntp.neuroscience.wisc.edu/neuro670/reqreading/Derivation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011244104","display_name":"Michael J. Shamblott","orcid":"https://orcid.org/0009-0001-8052-1118","observed_orcids":["https://orcid.org/0009-0001-8052-1118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Shamblott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071145540","display_name":"Joyce Axelman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce Axelman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000339138","display_name":"Shun-Ping Wang","orcid":"https://orcid.org/0000-0002-7688-1671","observed_orcids":["https://orcid.org/0000-0002-7688-1671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shun-Ping Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7688-1671","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073092334","display_name":"Elizabeth M. Bugg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth M. Bugg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036187248","display_name":"John W. Littlefield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W. Littlefield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101645127","display_name":"Peter J. Donovan","orcid":"https://orcid.org/0000-0003-2557-664X","observed_orcids":["https://orcid.org/0000-0003-2557-664X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Donovan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070260372","display_name":"Aul D. Blumenthal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aul D. Blumenthal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045182409","display_name":"R. Huggins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Huggins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111897637","display_name":"John D. Gearhart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Gearhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15470604,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluripotent-stem-cells","display_name":"pluripotent stem cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/embryonic-germ-cells","display_name":"embryonic germ cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.7900000214576721},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.7929999828338623},{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.8690000176429749},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tra-1-60","display_name":"TRA-1-60","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tra-1-81","display_name":"TRA-1-81","score":0.9980000257492065},{"id":"https://openalex.org/keywords/germ-layer-differentiation","display_name":"germ layer differentiation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/karyotype-stability","display_name":"karyotype stability","score":0.7409999966621399},{"id":"https://openalex.org/keywords/human-embryonic-development","display_name":"human embryonic development","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.8849259614944458},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7657497525215149},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7533054351806641},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7389546632766724},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7351996302604675},{"id":"https://openalex.org/C23416140","wikidata":"https://www.wikidata.org/wiki/Q6335239","display_name":"KOSR","level":5,"score":0.7204616069793701},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.56175297498703},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5465914011001587},{"id":"https://openalex.org/C26805974","wikidata":"https://www.wikidata.org/wiki/Q7117837","display_name":"P19 cell","level":5,"score":0.46545130014419556},{"id":"https://openalex.org/C207168726","wikidata":"https://www.wikidata.org/wiki/Q18050439","display_name":"Rex1","level":5,"score":0.4427078068256378},{"id":"https://openalex.org/C27284151","wikidata":"https://www.wikidata.org/wiki/Q6534502","display_name":"Leukemia inhibitory factor","level":4,"score":0.4403672516345978},{"id":"https://openalex.org/C138851942","wikidata":"https://www.wikidata.org/wiki/Q4747406","display_name":"Amniotic epithelial cells","level":5,"score":0.42964625358581543},{"id":"https://openalex.org/C190446060","wikidata":"https://www.wikidata.org/wiki/Q5550959","display_name":"Germ line development","level":4,"score":0.4115036725997925},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4107569754123688},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4083011746406555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10922205448150635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10602506995201111},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188474471","doi":null,"is_oa":false,"landing_page_url":"http://ntp.neuroscience.wisc.edu/neuro670/reqreading/Derivation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1902334072","https://openalex.org/W2103478108","https://openalex.org/W2258332741"],"related_works":["https://openalex.org/W2056489392","https://openalex.org/W2379124063","https://openalex.org/W2053750760","https://openalex.org/W1986502669","https://openalex.org/W1850753989","https://openalex.org/W2387905827","https://openalex.org/W2488995842","https://openalex.org/W2910136331","https://openalex.org/W7096781535","https://openalex.org/W2016937312"],"abstract_inverted_index":{"Human":[0],"pluripotent":[1,23,93,212],"stem":[2,24,94,98,144,213],"cells":[3,34,95,109,150,214],"would":[4],"be":[5,115,158],"in-":[6],"valuable":[7],"for":[8,211],"in":[9,47,67],"vitro":[10],"studies":[11],"of":[12,14,21,50,79,91,125,174,185,191],"aspects":[13],"human":[15,51,56,205],"embryogen-":[16],"esis.":[17],"With":[18],"the":[19,48,105,111,209],"goal":[20],"establishing":[22],"cell":[25,167,187],"lines,":[26],"gonadal":[27],"ridges":[28],"and":[29,62,99,119,134,145,155,161,165,201,215],"mesenteries":[30],"containing":[31],"primordial":[32],"germ":[33,101,195],"(PGCs,":[35],"5-9":[36],"weeks":[37],"postfertilization)":[38],"were":[39,69],"cultured":[40,149],"on":[41,198],"mouse":[42,92],"STO":[43],"fibroblast":[44,59],"feeder":[45],"layers":[46],"presence":[49],"recombinant":[52,57],"leukemia":[53],"inhibitory":[54],"factor,":[55,61],"basic":[58],"growth":[60],"forskolin.":[63],"Initially,":[64],"single":[65],"PGCs":[66,82],"culture":[68,106],"visualized":[70],"by":[71],"alkaline":[72,116],"phosphatase":[73],"activity":[74],"staining.":[75],"Over":[76],"a":[77,123,182],"period":[78,107],"7-21":[80],"days,":[81],"gave":[83],"rise":[84],"to":[85,114,141,157],"large":[86],"multicellular":[87],"colonies":[88,112],"resembling":[89],"those":[90],"termed":[96],"embryonic":[97,100,143,194],"(EG)":[102],"cells.":[103,147,220],"Throughout":[104],"most":[108,216],"within":[110],"continued":[113],"phosphatase-":[117],"positive":[118,121],"tested":[120],"against":[122],"panel":[124],"five":[126],"immuno-":[127],"logical":[128],"markers":[129],"(SSEA-1,":[130],"SSEA-3,":[131],"SSEA-4,":[132],"TRA-1-60,":[133],"TRA-1-81)":[135],"that":[136],"have":[137,151,169],"been":[138,152,170],"used":[139],"routinely":[140],"characterize":[142],"EG":[146,219],"The":[148],"continuously":[153],"passaged":[154],"found":[156],"karyotypically":[159],"normal":[160],"stable.":[162],"Both":[163],"XX":[164],"XY":[166],"cultures":[168,180,207],"obtained.":[171],"Immunohistochemical":[172],"analysis":[173],"embryoid":[175],"bodies":[176],"collected":[177],"from":[178],"these":[179,204],"revealed":[181],"wide":[183],"variety":[184],"differentiated":[186],"types,":[188],"including":[189],"derivatives":[190],"all":[192],"three":[193],"layers.":[196],"Based":[197],"their":[199],"origin":[200],"demonstrated":[202],"properties,":[203],"PGC-derived":[206],"meet":[208],"criteria":[210],"closely":[217],"resemble":[218]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}
