{"id":"https://openalex.org/W2188461807","doi":null,"title":"Possible role of secreted proteinases in Candida albicans infections.","display_name":"Possible role of secreted proteinases in Candida albicans infections.","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2188461807","mag":"2188461807","pmid":"https://pubmed.ncbi.nlm.nih.gov/17655411"},"language":"en","primary_location":{"id":"pmid:17655411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17655411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista iberoamericana de micologia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011368040","display_name":"Bernhard Hube","orcid":"https://orcid.org/0000-0002-6028-0425","observed_orcids":["https://orcid.org/0000-0002-6028-0425"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"B Hube","raw_affiliation_strings":["Institute for General Botany, Applied Molecular Biology III, University of Hamburg, Germany. Bernhard.Hube@hki-jena.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for General Botany, Applied Molecular Biology III, University of Hamburg, Germany. Bernhard.Hube@hki-jena.de","institution_ids":["https://openalex.org/I159176309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011368040"],"corresponding_institution_ids":["https://openalex.org/I159176309"],"apc_list":null,"apc_paid":null,"fwci":2.2072,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.88765068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"15","issue":"2","first_page":"65","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.23999999463558197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":1.0},{"id":"https://openalex.org/keywords/secreted-aspartyl-proteinases","display_name":"secreted aspartyl proteinases","score":0.9819999933242798},{"id":"https://openalex.org/keywords/extracellular-proteolytic-activity","display_name":"extracellular proteolytic activity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/signal-peptidase","display_name":"signal peptidase","score":0.8980000019073486},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6290000081062317},{"id":"https://openalex.org/keywords/oral-candidiasis","display_name":"oral candidiasis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/systemic-candidiasis","display_name":"systemic candidiasis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vaginal-candidiasis","display_name":"vaginal candidiasis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/fungal-pathogenesis","display_name":"fungal pathogenesis","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.843094527721405},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7275041341781616},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6544104814529419},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6387998461723328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.635860800743103},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6062400937080383},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.544096052646637},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.49032357335090637},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4844948947429657},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4612504541873932},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4562252163887024},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.44491803646087646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35242050886154175},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10893326997756958}],"mesh":[],"locations_count":2,"locations":[{"id":"pmid:17655411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17655411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista iberoamericana de micologia","raw_type":"Journal Article"},{"id":"mag:2188461807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17655411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W2092774","https://openalex.org/W160669962","https://openalex.org/W243109808","https://openalex.org/W1778564703","https://openalex.org/W1838815905","https://openalex.org/W1844745146","https://openalex.org/W1886048289","https://openalex.org/W1917147450","https://openalex.org/W1919706581","https://openalex.org/W1923066968","https://openalex.org/W1929325285","https://openalex.org/W1932377378","https://openalex.org/W1940172671","https://openalex.org/W1954009522","https://openalex.org/W1967859113","https://openalex.org/W1970405892","https://openalex.org/W2002390657","https://openalex.org/W2004842899","https://openalex.org/W2012411554","https://openalex.org/W2013120955","https://openalex.org/W2051853225","https://openalex.org/W2071503137","https://openalex.org/W2076738378","https://openalex.org/W2078784636","https://openalex.org/W2082527821","https://openalex.org/W2084021973","https://openalex.org/W2089819283","https://openalex.org/W2095384792","https://openalex.org/W2099618317","https://openalex.org/W2104191600","https://openalex.org/W2106551743","https://openalex.org/W2109722681","https://openalex.org/W2114471665","https://openalex.org/W2115355392","https://openalex.org/W2119993819","https://openalex.org/W2121580730","https://openalex.org/W2122642926","https://openalex.org/W2125605543","https://openalex.org/W2129707391","https://openalex.org/W2130497216","https://openalex.org/W2142727628","https://openalex.org/W2149300340","https://openalex.org/W2149633006","https://openalex.org/W2154492185","https://openalex.org/W2163234775","https://openalex.org/W2164828944","https://openalex.org/W2165330893","https://openalex.org/W2169734590","https://openalex.org/W2171577438","https://openalex.org/W2402718454","https://openalex.org/W4303109149"],"related_works":["https://openalex.org/W2137959581","https://openalex.org/W2241499157","https://openalex.org/W2402718454","https://openalex.org/W2094405531","https://openalex.org/W2106551743","https://openalex.org/W852554302","https://openalex.org/W1992693662","https://openalex.org/W7100192092","https://openalex.org/W2225850017","https://openalex.org/W1921022470"],"abstract_inverted_index":{"Extracellular":[0],"proteolytic":[1],"activity":[2,13],"of":[3,14,74,83,123],"the":[4,12,35,120,127],"human":[5],"pathogen":[6],"Candida":[7],"albicans":[8,131],"is":[9],"due":[10],"to":[11],"at":[15,34],"least":[16],"nine":[17],"secreted":[18],"aspartyl":[19],"proteinase":[20],"(Sap)":[21],"isoenzymes.":[22],"SAP1-9":[23],"genes":[24,40],"are":[25,41,46],"differentially":[26],"regulated":[27],"both":[28],"in":[29,32,70,129],"vitro":[30,57],"and":[31,52,77,107],"vivo":[33,81],"transcriptional":[36],"level.":[37],"All":[38],"SAP":[39],"translated":[42],"into":[43],"preproenzymes,":[44],"which":[45],"processed":[47],"by":[48,94],"a":[49,53,68,98],"signal":[50],"peptidase":[51],"Kex2-like":[54],"proteinase.":[55],"In":[56,80],"experiments":[58],"using":[59],"purified":[60],"Saps":[61,65],"suggested":[62],"that":[63],"active":[64],"may":[66],"play":[67],"role":[69,100],"attachment,":[71],"colonization,":[72],"penetration":[73],"host":[75],"tissues":[76],"immune":[78],"evasion.":[79],"expression":[82],"SAP1-6":[84,102],"during":[85,103,110],"oral":[86],"candidosis":[87],"was":[88],"established.":[89],"Using":[90],"sap":[91],"mutants,":[92],"produced":[93],"targeted":[95],"gene":[96],"disruption,":[97],"prominent":[99],"for":[101,108,126],"murine":[104],"disseminated":[105],"infections":[106,113],"SAP1-3":[109],"rat":[111],"vaginal":[112],"could":[114],"be":[115],"demonstrated.":[116],"These":[117],"data":[118],"underline":[119],"general":[121],"importance":[122],"extracellular":[124],"proteinases":[125],"pathogenesis":[128],"C.":[130],"infections.":[132]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}