{"id":"https://openalex.org/W2188460153","doi":null,"title":"Utility of urinary biomarkers in oral cancer.","display_name":"Utility of urinary biomarkers in oral cancer.","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W2188460153","mag":"2188460153","pmid":"https://pubmed.ncbi.nlm.nih.gov/17696737"},"language":"en","primary_location":{"id":"pmid:17696737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17696737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102326155","display_name":"Jayendra B. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289784979","display_name":"University College Hospital","ror":"https://ror.org/00wrevg56","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289784979","https://openalex.org/I1340918713"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jayendra B Patel","raw_affiliation_strings":["Biochemistry Research Division, University College Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Research Division, University College Hospital, London, UK","institution_ids":["https://openalex.org/I1289784979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112298252","display_name":"Shilin Nandubhai Shukla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shilin N Shukla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074073988","display_name":"Hiten Patel","orcid":"https://orcid.org/0000-0002-0921-1029","observed_orcids":["https://orcid.org/0000-0002-0921-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiten R  H Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049596580","display_name":"Kiran K Kothari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiran K Kothari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112043333","display_name":"Pankaj Manubhai Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pankaj M Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086583330","display_name":"Prabhudas Shankarbhai Patel","orcid":"https://orcid.org/0000-0003-1004-7024","observed_orcids":["https://orcid.org/0000-0003-1004-7024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prabhudas S Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8438,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71473171,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"2","first_page":"229","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.625,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.625,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.19370000064373016,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":1.0},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.890999972820282},{"id":"https://openalex.org/keywords/tobacco-smoke-exposure","display_name":"tobacco smoke exposure","score":0.6470000147819519},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.7200000286102295},{"id":"https://openalex.org/keywords/urinary-cotinine","display_name":"urinary cotinine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oral-precancer","display_name":"oral precancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tobacco-chewing","display_name":"tobacco chewing","score":0.765999972820282},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7699999809265137},{"id":"https://openalex.org/keywords/smoking-abstinence","display_name":"smoking abstinence","score":0.6650000214576721},{"id":"https://openalex.org/keywords/oral-cancer-screening","display_name":"oral cancer screening","score":0.8529999852180481},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8073813319206238},{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.6866748332977295},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6655948162078857},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6514005661010742},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.584559977054596},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5667340755462646},{"id":"https://openalex.org/C142083821","wikidata":"https://www.wikidata.org/wiki/Q1345873","display_name":"Chewing tobacco","level":3,"score":0.5134721398353577},{"id":"https://openalex.org/C2780687700","wikidata":"https://www.wikidata.org/wiki/Q210978","display_name":"Abstinence","level":2,"score":0.48944488167762756},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4772891104221344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4657166004180908},{"id":"https://openalex.org/C2778355491","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Tobacco smoke","level":2,"score":0.43941372632980347},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3570970892906189},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3480783700942993},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.13446933031082153},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003367","descriptor_name":"Cotinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014030","descriptor_name":"Tobacco, Smokeless","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17696737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17696737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:44932","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/44932/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Pac.J.Cancer Prev. , 8 (2) pp. 229-235. (2007)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W179236620","https://openalex.org/W1486490528","https://openalex.org/W1605134927","https://openalex.org/W1900745474","https://openalex.org/W1940590393","https://openalex.org/W1965174529","https://openalex.org/W1981163451","https://openalex.org/W1987753850","https://openalex.org/W1990802251","https://openalex.org/W1999575578","https://openalex.org/W2001356545","https://openalex.org/W2020466267","https://openalex.org/W2021987181","https://openalex.org/W2022611068","https://openalex.org/W2034452624","https://openalex.org/W2052912625","https://openalex.org/W2058342218","https://openalex.org/W2074772928","https://openalex.org/W2084697685","https://openalex.org/W2085114077","https://openalex.org/W2110098780","https://openalex.org/W2115371904","https://openalex.org/W2131749014","https://openalex.org/W2139939499","https://openalex.org/W2141024484","https://openalex.org/W2142259952","https://openalex.org/W2148071155","https://openalex.org/W2148565792","https://openalex.org/W2171924267"],"related_works":["https://openalex.org/W2023242587","https://openalex.org/W4213039771","https://openalex.org/W4399147511","https://openalex.org/W3136757739","https://openalex.org/W4237775620","https://openalex.org/W2987435463","https://openalex.org/W2020909853","https://openalex.org/W2511733242","https://openalex.org/W7217610866","https://openalex.org/W2269998146"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Oral":[1,76],"cancer":[2,50,77,186,237],"is":[3],"the":[4,16,21,96,191,197,213,239],"leading":[5],"malignancy":[6],"in":[7,15,29,41,119,134,179,212,238],"India,":[8],"with":[9,44,70,79,162,182,190,216],"tobacco":[10,30,37,64,73,81,120,138,161,224],"playing":[11],"a":[12,80,113],"major":[13],"role":[14],"etiology.":[17],"The":[18,146,220],"aim":[19],"of":[20,63,72,117,137,154,160,165,167,204,235,242],"present":[22],"study":[23,36,97],"was":[24,195],"to":[25,35,93,143],"quantify":[26],"nitrate+nitrite":[27],"(NO2+NO3)":[28],"products":[31],"as":[32,34,188],"well":[33],"exposure":[38],"related":[39],"biomarkers":[40],"controls,":[42],"patients":[43,78,181,187],"oral":[45,49,168,185,217,236,259],"precancers":[46],"(OPC)":[47],"and":[48,67,88,101,121,123,157,173,184,207,226,249],"patients.":[51],"MATERIALS":[52],"&":[53],"METHODS:":[54],"Healthy":[55],"individuals":[56,69],"(n=90)":[57],"were":[58,83,104,127,176,209],"grouped":[59],"into":[60,85],"without":[61],"habit":[62,71,82],"(NHT,":[65],"n=30)":[66],"healthy":[68],"(WHT,":[74],"n=60).":[75],"classified":[84],"abstinence":[86],"(n=62)":[87],"non-abstinence":[89,214],"(n=64)":[90],"groups":[91],"according":[92],"status":[94],"at":[95],"time.":[98],"Urinary":[99,170,245],"nicotine":[100,206],"cotinine":[102,172,208],"levels":[103,126,133,175,251],"analyzed":[105],"by":[106,129],"modified":[107],"high-pressure":[108],"liquid":[109],"chromatography":[110],"(HPLC)":[111],"using":[112],"UV":[114],"detector.":[115],"Levels":[116,203],"NO2+NO3":[118,132,174,248],"urine,":[122],"urinary":[124,200,205],"thioether":[125,201,250],"estimated":[128],"spectrophotometry.":[130],"RESULTS:":[131],"different":[135],"types":[136],"product":[139],"ranged":[140],"between":[141],"0.13":[142],"3.39":[144],"mg/g.":[145],"Odds":[147],"Ratio":[148],"(OR)":[149],"analysis":[150],"indicated":[151],"positive":[152],"associations":[153],"both":[155],"smoking":[156,227],"chewing":[158,225],"habits":[159,228],"high":[163],"risk":[164,231],"development":[166,234],"cancer.":[169,260],"nicotine,":[171,246],"significantly":[177],"elevated":[178],"WHT,":[180],"OPC":[183],"compared":[189],"NHT":[192],"group.":[193],"This":[194],"also":[196,210],"case":[198],"for":[199,233,255,258],"levels.":[202],"higher":[211],"group":[215],"cancers.":[218],"CONCLUSION:":[219],"results":[221],"confirmed":[222],"that":[223],"are":[229],"prominent":[230],"factors":[232],"western":[240],"part":[241],"India":[243],"(Gujarat).":[244],"cotinine,":[247],"can":[252],"be":[253],"helpful":[254],"screening":[256],"programs":[257]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}