{"id":"https://openalex.org/W2188451410","doi":null,"title":"Chemopreventive effect of 4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid (TAC-101) on MNU-induced colon carcinogenesis in a rat model.","display_name":"Chemopreventive effect of 4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid (TAC-101) on MNU-induced colon carcinogenesis in a rat model.","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2188451410","mag":"2188451410","pmid":"https://pubmed.ncbi.nlm.nih.gov/19528465"},"language":"en","primary_location":{"id":"pmid:19528465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19528465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054857947","display_name":"Yoshifumi Nakayama","orcid":"https://orcid.org/0000-0001-6010-5398","observed_orcids":["https://orcid.org/0000-0001-6010-5398"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi Nakayama","raw_affiliation_strings":["Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, Yahata-nishi-ku, Kita-kyushu 807, Japan. nakayama@med.uoeh-u.ac.jp","Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, Yahata-nishi-ku, Kita-kyushu 807, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, Yahata-nishi-ku, Kita-kyushu 807, Japan. nakayama@med.uoeh-u.ac.jp","institution_ids":["https://openalex.org/I188700360"]},{"raw_affiliation_string":"Department of Surgery 1, School of Medicine, University of Occupational Environmental Health, Yahata-nishi-ku, Kita-kyushu 807, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102377118","display_name":"Yuzuru Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuzuru Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110114896","display_name":"Noritaka Minagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noritaka Minagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030368452","display_name":"Koji Onitsuka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Onitsuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041968257","display_name":"Jun Nagata","orcid":"https://orcid.org/0000-0003-4592-8497","observed_orcids":["https://orcid.org/0000-0003-4592-8497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Nagata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050653476","display_name":"Kazunori Shibao","orcid":"https://orcid.org/0000-0001-7603-5996","observed_orcids":["https://orcid.org/0000-0001-7603-5996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazunori Shibao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071060001","display_name":"Keiji Hirata","orcid":"https://orcid.org/0000-0001-6461-5109","observed_orcids":["https://orcid.org/0000-0001-6461-5109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiji Hirata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008026652","display_name":"\u9054\u5f66 \u4f50\u53e4","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatsuhiko Sako","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112850506","display_name":"Naoki Nagata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Nagata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100606846","display_name":"Koji Yamaguchi","orcid":"https://orcid.org/0000-0002-8758-6598","observed_orcids":["https://orcid.org/0000-0002-8758-6598"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Yamaguchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2161,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55892411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"29","issue":"6","first_page":"2059","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.14920000731945038,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.14149999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8730000257492065},{"id":"https://openalex.org/keywords/colon-carcinogenesis","display_name":"colon carcinogenesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/n-methyl-n-nitrosourea","display_name":"N-methyl-N-nitrosourea","score":0.9909999966621399},{"id":"https://openalex.org/keywords/aberrant-crypt-foci","display_name":"aberrant crypt foci","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.781000018119812},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9089999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fas-expression","display_name":"Fas expression","score":0.9409999847412109},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.7592810392379761},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6592462062835693},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6195614337921143},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6147795915603638},{"id":"https://openalex.org/C2780669762","wikidata":"https://www.wikidata.org/wiki/Q4667164","display_name":"Aberrant crypt foci","level":5,"score":0.49722006916999817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4492201507091522},{"id":"https://openalex.org/C2777000832","wikidata":"https://www.wikidata.org/wiki/Q419853","display_name":"Trimethylsilyl","level":2,"score":0.4195738732814789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4079010486602783},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4064036011695862},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34634026885032654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3427410125732422},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3357686698436737},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2996494770050049},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21524137258529663},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13184243440628052},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.09577295184135437},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000477","descriptor_name":"Alkylating Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008770","descriptor_name":"Methylnitrosourea","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014297","descriptor_name":"Trimethylsilyl Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19528465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19528465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2188451410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19528465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W18689241","https://openalex.org/W131820425","https://openalex.org/W175518023","https://openalex.org/W1529615942","https://openalex.org/W1591707748","https://openalex.org/W1825062505","https://openalex.org/W1923263537","https://openalex.org/W1931027255","https://openalex.org/W1966165057","https://openalex.org/W1968104549","https://openalex.org/W1975076018","https://openalex.org/W1984155747","https://openalex.org/W1987718268","https://openalex.org/W1991865867","https://openalex.org/W1994994559","https://openalex.org/W1995216988","https://openalex.org/W1995956328","https://openalex.org/W1998761065","https://openalex.org/W2001791567","https://openalex.org/W2010923377","https://openalex.org/W2012603529","https://openalex.org/W2012968754","https://openalex.org/W2018909089","https://openalex.org/W2037952228","https://openalex.org/W2040468663","https://openalex.org/W2054367080","https://openalex.org/W2068788006","https://openalex.org/W2071290456","https://openalex.org/W2073914550","https://openalex.org/W2093801980","https://openalex.org/W2097903769","https://openalex.org/W2099566069","https://openalex.org/W2108731507","https://openalex.org/W2124419959","https://openalex.org/W2138432364","https://openalex.org/W2139863597","https://openalex.org/W2142627696","https://openalex.org/W2154015002","https://openalex.org/W2158572807","https://openalex.org/W2164857934","https://openalex.org/W2265752866","https://openalex.org/W2319872820","https://openalex.org/W2339318589","https://openalex.org/W2395033756","https://openalex.org/W2400509040","https://openalex.org/W2403412586","https://openalex.org/W2413569746","https://openalex.org/W2417419740"],"related_works":["https://openalex.org/W2158572807","https://openalex.org/W18689241","https://openalex.org/W1956678452","https://openalex.org/W2395799132","https://openalex.org/W7100417442","https://openalex.org/W2136616371","https://openalex.org/W2152572678","https://openalex.org/W4312939006","https://openalex.org/W2045679237","https://openalex.org/W2137084530"],"abstract_inverted_index":{"PURPOSE:":[0],"4-[3,5-Bis(trimethylsilyl)benzamido]":[1],"benzoic":[2],"acid":[3,9],"(TAC-101)":[4],"is":[5,226],"a":[6,24,207,220],"novel":[7],"retinobenzoic":[8],"derivative.":[10],"The":[11,119,211],"chemopreventive":[12],"effect":[13],"and":[14,73,93,110,122,177,185],"the":[15,78,86,96,123,127,139,146,155,168,172,175,178,183,186,196],"mechanism":[16,212],"of":[17,19,40,88,148,195,209,213],"action":[18],"TAC-101":[20,199],"were":[21,35,48,81,98,113,132,190],"investigated":[22],"using":[23,37,116],"rat":[25],"chemical":[26],"colon":[27,97,204],"carcinogenesis":[28,205],"model.":[29],"MATERIALS":[30],"AND":[31],"METHODS:":[32],"Colon":[33],"tumors":[34,94],"induced":[36,203],"intra-rectal":[38],"instillation":[39],"N-methyl-N-nitrosourea":[41],"(MNU)":[42],"in":[43,95,126,134,138,154,163,167,182,193,222],"F344":[44],"rats.":[45],"These":[46],"rats":[47],"divided":[49],"into":[50],"five":[51],"groups,":[52,141],"control,":[53],"high":[54,62,128,156],"dose":[55,68],"(TAC-101":[56,69],"8":[57],"mg/kg)-long":[58,71],"period":[59,64,72,130,158],"(four":[60],"weeks),":[61],"dose-short":[63,75],"(one":[65],"week),":[66],"low":[67,74],"0.8":[70],"period.":[76],"After":[77],"large":[79],"bowels":[80],"resected":[82],"at":[83],"20":[84],"weeks,":[85],"number":[87,125,147],"aberrant":[89],"crypt":[90],"foci":[91],"(ACF)":[92],"counted.":[99],"Proliferating":[100],"cell":[101,223],"nuclear":[102],"antigen":[103],"(PCNA)":[104],"positive":[105,152],"index,":[106],"apoptotic":[107],"index":[108],"(AI)":[109],"Fas":[111,179],"expression":[112,180],"also":[114],"evaluated":[115],"immunohistochemistry.":[117],"RESULTS:":[118],"tumor":[120,124,184],"incidence":[121],"dose-long":[129,157],"group":[131,159],"decreased":[133,162],"comparison":[135,164],"to":[136,165,219],"those":[137],"other":[140,169,173],"but":[142,225],"not":[143,191,227],"significantly.":[144],"However,":[145],"ACF":[149],"or":[150],"PCNA":[151],"indices":[153],"was":[160],"significantly":[161],"that":[166],"groups.":[170,197],"On":[171],"hand,":[174],"AI":[176],"pattern":[181],"normal":[187],"appearing":[188],"mucosa":[189],"changed":[192],"any":[194],"CONCLUSION:":[198],"might":[200],"inhibit":[201],"MNU":[202],"via":[206],"decrease":[208],"ACF.":[210],"this":[214],"chemoprevention":[215],"may":[216],"be":[217],"related":[218],"reduction":[221],"proliferation,":[224],"directly":[228],"associated":[229],"with":[230],"apoptosis.":[231]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
