{"id":"https://openalex.org/W2188409908","doi":null,"title":"The Use of Doxycycline in Micro- filaremic Dirofilaria immitis (Leidy, 1856) Naturally Infected Dogs","display_name":"The Use of Doxycycline in Micro- filaremic Dirofilaria immitis (Leidy, 1856) Naturally Infected Dogs","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2188409908","mag":"2188409908"},"language":"en","primary_location":{"id":"mag:2188409908","doi":null,"is_oa":false,"landing_page_url":"http://www.jarvm.com/articles/Vol6Iss1/Labarthe%2055-59.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025007460","display_name":"Alexandre Jos\u00e9 Rodrigues Bendas","orcid":"https://orcid.org/0000-0003-4320-9923","observed_orcids":["https://orcid.org/0000-0003-4320-9923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Jos\u00e9 Rodrigues Bendas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4320-9923","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043635437","display_name":"Jonimar Pereira Paiva","orcid":"https://orcid.org/0000-0002-3749-7597","observed_orcids":["https://orcid.org/0000-0002-3749-7597"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonimar Pereira Paiva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3749-7597","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104364692","display_name":"Mar\u00eda In\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda In\u00e9s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014310441","display_name":"Daise Aparecida Rossi","orcid":"https://orcid.org/0000-0003-2003-696X","observed_orcids":["https://orcid.org/0000-0003-2003-696X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082725194","display_name":"Fabiana Batalha Knackfuss","orcid":"https://orcid.org/0000-0003-4560-1339","observed_orcids":["https://orcid.org/0000-0003-4560-1339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiana Batalha Knackfuss","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4560-1339","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000630694","display_name":"Danielly R. B. Silvano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielly R. B. Silvano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062072023","display_name":"Flavya Mendes-de-Almeida","orcid":"https://orcid.org/0000-0002-8152-5057","observed_orcids":["https://orcid.org/0000-0002-8152-5057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flavya Mendes-de-Almeida","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8152-5057","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062710773","display_name":"Jorge Guerrero","orcid":"https://orcid.org/0009-0006-1403-2670","observed_orcids":["https://orcid.org/0009-0006-1403-2670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Guerrero","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1403-2670","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.444,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6992762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dirofilaria-immitis","display_name":"Dirofilaria immitis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/heartworm-disease","display_name":"heartworm disease","score":0.7730000019073486},{"id":"https://openalex.org/keywords/microfilaremia","display_name":"microfilaremia","score":0.843999981880188},{"id":"https://openalex.org/keywords/wolbachia","display_name":"Wolbachia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tetracycline-antibiotics","display_name":"tetracycline antibiotics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5910000205039978},{"id":"https://openalex.org/keywords/endosymbionts","display_name":"endosymbionts","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2776355835","wikidata":"https://www.wikidata.org/wiki/Q134669","display_name":"Dirofilaria immitis","level":3,"score":0.9568613171577454},{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.9416279792785645},{"id":"https://openalex.org/C2779356413","wikidata":"https://www.wikidata.org/wiki/Q283526","display_name":"Wolbachia","level":3,"score":0.7943086624145508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6716007590293884},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5530732274055481},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.5074004530906677},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5005669593811035},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.49857664108276367},{"id":"https://openalex.org/C2776444496","wikidata":"https://www.wikidata.org/wiki/Q443929","display_name":"Dirofilariasis","level":2,"score":0.4801761209964752},{"id":"https://openalex.org/C2779359454","wikidata":"https://www.wikidata.org/wiki/Q6839512","display_name":"Microfilaria","level":4,"score":0.4487725794315338},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.42879366874694824},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3862202763557434},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3848281502723694},{"id":"https://openalex.org/C2777629521","wikidata":"https://www.wikidata.org/wiki/Q815753","display_name":"Filariasis","level":3,"score":0.3494867980480194},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3235138952732086},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.21279460191726685},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16485807299613953},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188409908","doi":null,"is_oa":false,"landing_page_url":"http://www.jarvm.com/articles/Vol6Iss1/Labarthe%2055-59.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W43999387","https://openalex.org/W121178472","https://openalex.org/W585497090","https://openalex.org/W1962380303","https://openalex.org/W1981292139","https://openalex.org/W1988414105","https://openalex.org/W2000445038","https://openalex.org/W2000569541","https://openalex.org/W2008217226","https://openalex.org/W2014467433","https://openalex.org/W2018525654","https://openalex.org/W2055177746","https://openalex.org/W2079358316","https://openalex.org/W2109360829","https://openalex.org/W2170307563","https://openalex.org/W2225340168","https://openalex.org/W2315125410","https://openalex.org/W2320694512","https://openalex.org/W2410761579","https://openalex.org/W2418384292","https://openalex.org/W2586511364"],"related_works":["https://openalex.org/W1973655900","https://openalex.org/W2036995233","https://openalex.org/W7204902803","https://openalex.org/W1995231517","https://openalex.org/W4280508622","https://openalex.org/W7203839049","https://openalex.org/W2966440669","https://openalex.org/W4411001012","https://openalex.org/W4380484429","https://openalex.org/W3034054714"],"abstract_inverted_index":{"Heartworm":[0],"is":[1,241],"a":[2,242],"mosquito-borne":[3],"disease":[4],"that":[5,222],"affects":[6],"different":[7],"mammalian":[8],"species":[9,40],"with":[10,94],"worldwide":[11],"distribution.":[12],"The":[13,39,75,207,245],"agent,":[14],"Dirofilaria":[15],"immitis":[16,42],"(Leidy,":[17],"1856),":[18],"infects":[19],"dogs":[20,88,93,128,133,139,145,161,186,252,254],"from":[21,182],"all":[22,141],"continents":[23],"and,":[24],"in":[25,33],"the":[26,28,36,49,57,67,73,78,153,156,175,193,202,223,226,232,236,239,265,268],"Americas,":[27],"parasite":[29],"has":[30],"been":[31],"detected":[32,124],"5":[34],"of":[35,48,69,77,80,84,97,119,155,174,218,225,238],"13":[37,160],"countries.":[38],"D":[41],"harbors":[43],"an":[44],"endosymbiont":[45],"intracellular":[46],"bacteria":[47,60],"genus":[50],"Wolbachia,":[51],"known":[52],"to":[53,63,212,270],"be":[54,147,199,213],"vital":[55],"for":[56,102,267],"worms.":[58,74],"These":[59],"are":[61,205],"sensitive":[62],"tetracycline-like":[64],"drugs,":[65],"therefore":[66],"use":[68,79],"antibiotics":[70],"can":[71,198],"affect":[72],"effect":[76,224],"doxycycline":[81,98,169],"on":[82,112,228,235],"microfilaremia":[83],"naturally":[85],"infected":[86,272],"microfilaremic":[87,164],"was":[89],"studied":[90],"by":[91,250],"treating":[92],"3":[95,142,203],"cycles":[96,204],"(10":[99],"mg/kg":[100],"SID":[101],"21":[103],"days)":[104],"at":[105,149,215],"6-month":[106],"intervals.":[107],"Blood":[108],"samples":[109],"were":[110,162,167,187,273],"collected":[111],"Days":[113],"0,":[114],"7,":[115],"21,":[116],"and":[117,122,125,137,181,231,255],"111":[118,173,217],"each":[120,219],"cycle":[121],"microfilariae":[123,194,208,247,257],"counted.":[126],"Thirteen":[127],"completed":[129,134,140],"1":[130],"cycle,":[131,177,220],"10":[132],"2":[135],"cycles,":[136],"6":[138],"cycles.":[143],"Five":[144],"could":[146],"sampled":[148],"7":[150],"months":[151],"after":[152],"end":[154],"third":[157],"cycle.":[158],"All":[159],"still":[163],"while":[165],"they":[166],"given":[168],"treatment.":[170],"On":[171],"Day":[172,216],"first":[176],"40%":[178],"became":[179],"amicrofilaremic":[180,185],"then":[183],"on,":[184],"always":[188],"detected.":[189],"Overall,":[190],"treatment":[191],"lowered":[192,246,256],"mean":[195,209],"counts,":[196],"which":[197],"observed":[200],"when":[201],"compared.":[206],"counts":[210],"tended":[211],"lower":[214],"suggesting":[221],"antibiotic":[227],"Wolbachia":[229],"organisms":[230],"consequent":[233],"impact":[234],"fitness":[237],"worms":[240],"slow":[243],"process.":[244],"stock":[248],"provided":[249],"doxycycline-treated":[251],"(amicrofilaremic":[253],"concentrations)":[258],"may":[259],"have":[260],"impaired":[261],"heartworm":[262],"transmission":[263],"once":[264],"chances":[266],"vectors":[269],"become":[271],"reduced.":[274]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}