{"id":"https://openalex.org/W2188407262","doi":null,"title":"Significant decrease of IgE antibodies after a three-year controlled study of specific immunotherapy to pollen allergens in children with allergic asthma.","display_name":"Significant decrease of IgE antibodies after a three-year controlled study of specific immunotherapy to pollen allergens in children with allergic asthma.","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W2188407262","mag":"2188407262","pmid":"https://pubmed.ncbi.nlm.nih.gov/15945499"},"language":"en","primary_location":{"id":"pmid:15945499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15945499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111630660","display_name":"Arnaldo Cantani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Cantani","raw_affiliation_strings":["Allergy and Clinical Immunology Division, Department of Pediatrics, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy and Clinical Immunology Division, Department of Pediatrics, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024876596","display_name":"Monica Micera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Micera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9395,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74163528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"2","first_page":"103","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pollen-allergens","display_name":"pollen allergens","score":0.8069999814033508},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ige-antibodies","display_name":"IgE antibodies","score":0.9269999861717224},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.9929999709129333},{"id":"https://openalex.org/keywords/early-childhood-asthma","display_name":"early childhood asthma","score":0.5040000081062317},{"id":"https://openalex.org/keywords/rhinitis","display_name":"rhinitis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/anaphylaxis-risk","display_name":"anaphylaxis risk","score":0.7020000219345093},{"id":"https://openalex.org/keywords/long-term-follow-up","display_name":"long-term follow-up","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8437325954437256},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7528412938117981},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7258623838424683},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.6424609422683716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6398171186447144},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5797445774078369},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5576797127723694},{"id":"https://openalex.org/C2909843257","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylactic reactions","level":4,"score":0.4367219805717468},{"id":"https://openalex.org/C2775933838","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylaxis","level":3,"score":0.3481062948703766},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33508455753326416},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21683034300804138}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011058","descriptor_name":"Pollen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011058","descriptor_name":"Pollen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15945499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15945499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Clinical Trial"},{"id":"mag:2188407262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15945499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W19065172","https://openalex.org/W66747899","https://openalex.org/W133729585","https://openalex.org/W1481619148","https://openalex.org/W1485987848","https://openalex.org/W1507050710","https://openalex.org/W1537422459","https://openalex.org/W1572656296","https://openalex.org/W1921245875","https://openalex.org/W1964994984","https://openalex.org/W1976346783","https://openalex.org/W1978203735","https://openalex.org/W1978561383","https://openalex.org/W1984574173","https://openalex.org/W1993775186","https://openalex.org/W1997289406","https://openalex.org/W2008723574","https://openalex.org/W2009280170","https://openalex.org/W2013227933","https://openalex.org/W2013244684","https://openalex.org/W2016700000","https://openalex.org/W2018186263","https://openalex.org/W2021648312","https://openalex.org/W2029130004","https://openalex.org/W2032260549","https://openalex.org/W2033978020","https://openalex.org/W2049218946","https://openalex.org/W2064004714","https://openalex.org/W2072636081","https://openalex.org/W2080024378","https://openalex.org/W2088309898","https://openalex.org/W2097087514","https://openalex.org/W2104537618","https://openalex.org/W2124871577","https://openalex.org/W2136756944","https://openalex.org/W2394530894","https://openalex.org/W2401322563","https://openalex.org/W2407394122","https://openalex.org/W2460243790","https://openalex.org/W2473414986"],"related_works":["https://openalex.org/W66747899","https://openalex.org/W2103029539","https://openalex.org/W2366223628","https://openalex.org/W2406214586","https://openalex.org/W2356967065","https://openalex.org/W3028938688","https://openalex.org/W3200450909","https://openalex.org/W2050040192","https://openalex.org/W2406149501","https://openalex.org/W2150187523"],"abstract_inverted_index":{"BACKGROUND:":[0],"Specific":[1],"immunotherapy":[2],"(SIT)":[3],"in":[4,19,90,108,121],"children":[5,20,54],"being":[6],"not":[7],"an":[8],"optional":[9],"treatment":[10,106,119,133],"should":[11],"be":[12],"administered":[13],"as":[14,16],"soon":[15],"possible,":[17],"also":[18],"aged":[21],"2-3":[22],"years,":[23],"due":[24],"to":[25,34,37],"the":[26,39,64,109,122,131,137],"very":[27,115],"early":[28],"asthma":[29],"and":[30,58,66,112],"rhinitis":[31],"onset,":[32],"contrarily":[33],"opponents":[35],"continuing":[36],"stress":[38,99],"danger":[40],"of":[41,70,73,92,140],"anaphylactic":[42],"reactions":[43],"without":[44],"displaying":[45],"reliable":[46],"data.":[47],"MATERIALS":[48],"AND":[49],"METHODS:":[50],"We":[51,98,126],"report":[52],"56":[53,59],"who":[55],"underwent":[56],"SIT":[57,93,129],"controls":[60],"seen":[61],"consecutevely":[62],"at":[63],"Allergy":[65],"Immunology":[67],"Division,":[68],"Department":[69],"Pediatrics,":[71],"University":[72],"Rome":[74],"\"La":[75],"Sapienza\".":[76],"The":[77],"control":[78],"group":[79],"was":[80],"treated":[81],"with":[82,94],"all":[83],"appropriate":[84],"medications.":[85],"RESULTS:":[86],"They":[87],"were":[88],"highly":[89],"favor":[91],"statistically":[95],"significant":[96],"differences.":[97],"that":[100,128],"IgE":[101],"antibodies":[102,114],"significantly":[103,116],"decreased":[104],"after":[105,118],"only":[107,120,132,146],"study":[110,123],"group,":[111],"IgG":[113],"increased":[117],"group.":[124],"DISCUSSION:":[125],"demonstrate":[127],"is":[130],"which":[134],"can":[135],"alter":[136],"natural":[138],"course":[139],"respiratory":[141],"diseases,":[142],"whereas":[143],"drugs":[144],"represent":[145],"a":[147],"symptomatic":[148],"treatment.":[149]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}