{"id":"https://openalex.org/W2188398753","doi":null,"title":"Gene expression and histopathology alterations during rat mammary carcinogenesis induced by 7,12- dimethylbenz(a)anthracene and the protective role of Neem (Azadirachta indica) leaf extract","display_name":"Gene expression and histopathology alterations during rat mammary carcinogenesis induced by 7,12- dimethylbenz(a)anthracene and the protective role of Neem (Azadirachta indica) leaf extract","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2188398753","mag":"2188398753"},"language":"en","primary_location":{"id":"mag:2188398753","doi":null,"is_oa":false,"landing_page_url":"http://www.jofamericanscience.org/journals/am-sci/am0609/96_3512am0609_843_859.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083974384","display_name":"Saleha Y. M. Alakilli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Saleha Y. M. alakilli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083974384"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0166,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.83072112,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.3668999969959259,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/7-12-dimethylbenz-a-anthracene","display_name":"7,12-dimethylbenz(a)anthracene","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neem-leaf-extract","display_name":"neem leaf extract","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neem","display_name":"Azadirachta indica","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.7789999842643738},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9279999732971191},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.972000002861023},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cytokeratin-8","display_name":"cytokeratin 8","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ck19","display_name":"CK19","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7720000147819519},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.5149999856948853},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C2778938436","wikidata":"https://www.wikidata.org/wiki/Q5205596","display_name":"DMBA","level":4,"score":0.9829163551330566},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.8091107606887817},{"id":"https://openalex.org/C2776260934","wikidata":"https://www.wikidata.org/wiki/Q187487","display_name":"7,12-Dimethylbenz[a]anthracene","level":5,"score":0.6930207014083862},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.5848774909973145},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5604473948478699},{"id":"https://openalex.org/C2781035296","wikidata":"https://www.wikidata.org/wiki/Q21698","display_name":"Azadirachta","level":2,"score":0.5061578154563904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4998054504394531},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.45494532585144043},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4466439187526703},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.41988396644592285},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37826013565063477},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3505987524986267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3336278796195984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31488505005836487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31020790338516235},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24172896146774292},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19481652975082397},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.17723912000656128},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06522977352142334},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188398753","doi":null,"is_oa":false,"landing_page_url":"http://www.jofamericanscience.org/journals/am-sci/am0609/96_3512am0609_843_859.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W102882773","https://openalex.org/W127043432","https://openalex.org/W183694329","https://openalex.org/W1504534505","https://openalex.org/W1519639337","https://openalex.org/W1540759808","https://openalex.org/W1559151410","https://openalex.org/W1561534261","https://openalex.org/W1971053488","https://openalex.org/W1972937115","https://openalex.org/W1973512839","https://openalex.org/W1975834732","https://openalex.org/W1989074935","https://openalex.org/W1989428273","https://openalex.org/W1989458660","https://openalex.org/W1989933820","https://openalex.org/W1991494214","https://openalex.org/W1998676034","https://openalex.org/W2005701790","https://openalex.org/W2008200838","https://openalex.org/W2014716127","https://openalex.org/W2038953750","https://openalex.org/W2045336861","https://openalex.org/W2051084226","https://openalex.org/W2054067827","https://openalex.org/W2054620686","https://openalex.org/W2054904912","https://openalex.org/W2058029299","https://openalex.org/W2059072983","https://openalex.org/W2061352113","https://openalex.org/W2064254181","https://openalex.org/W2075096138","https://openalex.org/W2081596593","https://openalex.org/W2083788758","https://openalex.org/W2085712878","https://openalex.org/W2086628071","https://openalex.org/W2087884848","https://openalex.org/W2097255042","https://openalex.org/W2099002987","https://openalex.org/W2099356009","https://openalex.org/W2103616303","https://openalex.org/W2114090345","https://openalex.org/W2128985829","https://openalex.org/W2131994307","https://openalex.org/W2141602478","https://openalex.org/W2144705309","https://openalex.org/W2147303539","https://openalex.org/W2163488649","https://openalex.org/W2170380264","https://openalex.org/W2188351280","https://openalex.org/W2394603733","https://openalex.org/W2406049477","https://openalex.org/W2408717386","https://openalex.org/W2412755445","https://openalex.org/W2419655347","https://openalex.org/W2474146955","https://openalex.org/W2565669773"],"related_works":["https://openalex.org/W1973512839","https://openalex.org/W7140804543","https://openalex.org/W4403188939","https://openalex.org/W2069026078","https://openalex.org/W6990695878","https://openalex.org/W2028333289","https://openalex.org/W1964917071","https://openalex.org/W1983886396","https://openalex.org/W2156396077","https://openalex.org/W2342430294"],"abstract_inverted_index":{"The":[0,120,151],"present":[1],"study":[2],"was":[3,132,149],"investigated":[4,133],"to":[5,80,100,163,230],"evaluate":[6],"the":[7,22,36,81,85,88,109,146,179,185,215,219,223],"protective":[8],"role":[9],"of":[10,21,39,77,87,117,122,145,160,173,178,226,233],"ethanolic":[11],"neem":[12],"leaf":[13],"extract":[14],"(ENLE)":[15],"against":[16],"7,12-dimethylbenz(a)anthracene":[17],"(DMBA)-induced":[18],"expression":[19,121,158,181,217],"alterations":[20,159,177,213],"Bcl-2,":[23,123],"CK8,":[24,124],"CK19,":[25,125],"p53,":[26,126],"p21,":[27,127],"p27":[28,128],"and":[29,32,68,74,95,104,129,218],"PCNA":[30,130],"genes":[31,131,161],"histopathological":[33,166,186,220],"lesions":[34,167,187,221],"in":[35,170,214,222],"mammary":[37,147,171,224],"tissues":[38,148,172,225],"female":[40,45,174,192,227],"rats.":[41,175],"Eighty":[42],"Swiss":[43],"albino":[44],"rats":[46,193,228],"were":[47,111,168,188,194],"divided":[48],"into":[49],"eight":[50],"groups.":[51],"Group":[52,60],"1":[53],"supplemented":[54],"with":[55,196,199],"corn":[56],"oil":[57],"as":[58,182,184],"control.":[59],"2":[61],"females":[62,70,97],"received":[63,71],"DMBA.":[64,107,200,231],"Groups":[65,92],"3,":[66,102],"4":[67,103],"5":[69,105],"100,":[72],"200":[73],"400":[75],"mg/kg":[76],"ENLE":[78,197,206],"alternate":[79],"DMBA":[82,155],"application":[83],"from":[84],"beginning":[86],"experimental":[89,115],"period,":[90],"respectively.":[91],"6,":[93],"7,":[94],"8":[96],"treated":[98,195],"similar":[99],"groups":[101],"plus":[106],"All":[108],"animals":[110],"sacrificed":[112],"after":[113],"an":[114],"period":[116],"12":[118],"weeks.":[119],"using":[134],"reverse":[135],"transcription":[136],"polymerase":[137],"chain":[138],"reaction":[139],"(RT-PCR).":[140],"In":[141],"addition,":[142],"histopathology":[143],"analysis":[144],"confirmed.":[150],"results":[152],"revealed":[153],"that":[154,205],"treatment":[156],"induced":[157],"related":[162],"cancer.":[164],"Also":[165],"found":[169],"These":[176,202],"gene":[180,216],"well":[183],"markedly":[189],"suppressed":[190],"when":[191],"combined":[198],"Conclusion:":[201],"findings":[203],"suggest":[204],"exerts":[207],"its":[208],"anticancer":[209],"properties":[210],"by":[211],"inhibiting":[212],"exposed":[229],"(Journal":[232],"American":[234],"Science":[235],"2010;":[236],"6(9):843-859).":[237],"(ISSN:":[238],"1545-1003).":[239]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
