{"id":"https://openalex.org/W2188397336","doi":null,"title":"A Comprehensive Review of Thrombogenic Mechanisms in APS","display_name":"A Comprehensive Review of Thrombogenic Mechanisms in APS","publication_year":2010,"publication_date":"2010-03-11","ids":{"openalex":"https://openalex.org/W2188397336","mag":"2188397336"},"language":"en","primary_location":{"id":"mag:2188397336","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TOAUTOJ-2-58","pdf_url":null,"source":{"id":"https://openalex.org/S4210213910","display_name":"The Open Autoimmunity Journal","issn_l":"1876-8946","issn":["1876-8946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Autoimmunity Journal","raw_type":null},"volume":null,"type":"review","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058692616","display_name":"Renan Aguilar\u2010Valenzuela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renan Aguilar\u2010Valenzuela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028722551","display_name":"Laura-Aline Mart\u00ednez-Mart\u00ednez","orcid":"https://orcid.org/0000-0001-7439-2615","observed_orcids":["https://orcid.org/0000-0001-7439-2615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura-Aline Mart\u00ednez-Mart\u00ednez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7439-2615","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113505344","display_name":"Silvia S. Pierangeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia S. Pierangeli","raw_affiliation_strings":["University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1276,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.15303983,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":1.0},{"id":"https://openalex.org/keywords/acquired-thrombophilia","display_name":"acquired thrombophilia","score":0.875},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.9739999771118164},{"id":"https://openalex.org/keywords/anticardiolipin-antibodies","display_name":"anticardiolipin antibodies","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anti-beta2-glycoprotein-i-antibodies","display_name":"anti-beta2-glycoprotein I antibodies","score":0.9430000185966492},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8613097667694092},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.8284895420074463},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.8180620670318604},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5645495653152466},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.505207359790802},{"id":"https://openalex.org/C3018762881","wikidata":"https://www.wikidata.org/wiki/Q3774511","display_name":"Anticardiolipin antibodies","level":3,"score":0.4919759929180145},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46710243821144104},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4392986297607422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3670998811721802}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188397336","doi":null,"is_oa":false,"landing_page_url":"https://benthamopen.com/ABSTRACT/TOAUTOJ-2-58","pdf_url":null,"source":{"id":"https://openalex.org/S4210213910","display_name":"The Open Autoimmunity Journal","issn_l":"1876-8946","issn":["1876-8946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Open Autoimmunity Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W167774609","https://openalex.org/W178032782","https://openalex.org/W256717200","https://openalex.org/W1507049883","https://openalex.org/W1520470614","https://openalex.org/W1567044188","https://openalex.org/W1611720630","https://openalex.org/W1630341904","https://openalex.org/W1846075936","https://openalex.org/W1888200383","https://openalex.org/W1905168073","https://openalex.org/W1916272345","https://openalex.org/W1946061630","https://openalex.org/W1965771173","https://openalex.org/W1967363556","https://openalex.org/W1967602919","https://openalex.org/W1968168496","https://openalex.org/W1973361365","https://openalex.org/W1974008566","https://openalex.org/W1982207491","https://openalex.org/W1983377558","https://openalex.org/W1986570146","https://openalex.org/W1989836808","https://openalex.org/W1993295284","https://openalex.org/W1993393605","https://openalex.org/W1995342106","https://openalex.org/W1997265458","https://openalex.org/W2002239776","https://openalex.org/W2002709892","https://openalex.org/W2002937953","https://openalex.org/W2004368710","https://openalex.org/W2005844105","https://openalex.org/W2006834114","https://openalex.org/W2008273918","https://openalex.org/W2010012477","https://openalex.org/W2012271760","https://openalex.org/W2019789419","https://openalex.org/W2020722604","https://openalex.org/W2022161477","https://openalex.org/W2024072212","https://openalex.org/W2024343545","https://openalex.org/W2025097039","https://openalex.org/W2027467473","https://openalex.org/W2029241430","https://openalex.org/W2031334192","https://openalex.org/W2032274203","https://openalex.org/W2033560033","https://openalex.org/W2033863224","https://openalex.org/W2034449234","https://openalex.org/W2036878775","https://openalex.org/W2037655680","https://openalex.org/W2038535975","https://openalex.org/W2041610266","https://openalex.org/W2042987988","https://openalex.org/W2046838002","https://openalex.org/W2049278423","https://openalex.org/W2050019577","https://openalex.org/W2050158555","https://openalex.org/W2052883609","https://openalex.org/W2053081517","https://openalex.org/W2053890060","https://openalex.org/W2054330426","https://openalex.org/W2054644746","https://openalex.org/W2058021273","https://openalex.org/W2058913058","https://openalex.org/W2062466582","https://openalex.org/W2063070701","https://openalex.org/W2063854370","https://openalex.org/W2066040502","https://openalex.org/W2068492012","https://openalex.org/W2070760253","https://openalex.org/W2072477029","https://openalex.org/W2075162077","https://openalex.org/W2077468629","https://openalex.org/W2078927142","https://openalex.org/W2079127176","https://openalex.org/W2079704511","https://openalex.org/W2081597555","https://openalex.org/W2082616171","https://openalex.org/W2085569887","https://openalex.org/W2086180463","https://openalex.org/W2093253402","https://openalex.org/W2097046783","https://openalex.org/W2099288634","https://openalex.org/W2101831374","https://openalex.org/W2102727554","https://openalex.org/W2109060641","https://openalex.org/W2109451688","https://openalex.org/W2111330617","https://openalex.org/W2119933403","https://openalex.org/W2120450714","https://openalex.org/W2129784243","https://openalex.org/W2138715903","https://openalex.org/W2140483523","https://openalex.org/W2140865695","https://openalex.org/W2143086319","https://openalex.org/W2149913815","https://openalex.org/W2153006626","https://openalex.org/W2159553458","https://openalex.org/W2160872701","https://openalex.org/W2162248918","https://openalex.org/W2163666190","https://openalex.org/W2164922254","https://openalex.org/W2166688237","https://openalex.org/W2167210243","https://openalex.org/W2214611810","https://openalex.org/W2324653842","https://openalex.org/W2327141264","https://openalex.org/W2398917316","https://openalex.org/W2405455530","https://openalex.org/W2405847012","https://openalex.org/W2409761003","https://openalex.org/W2415371444","https://openalex.org/W2416635878","https://openalex.org/W2417996629","https://openalex.org/W2418760888","https://openalex.org/W2467766180","https://openalex.org/W2471203099","https://openalex.org/W2581626191","https://openalex.org/W3021852519"],"related_works":["https://openalex.org/W1553370111","https://openalex.org/W74364177","https://openalex.org/W4254888110","https://openalex.org/W1990276742","https://openalex.org/W68866559","https://openalex.org/W4408417579","https://openalex.org/W2194406839","https://openalex.org/W2401899554","https://openalex.org/W4394754972","https://openalex.org/W7164499207"],"abstract_inverted_index":{"The":[0],"antiphospholipid":[1,24],"syndrome":[2],"(APS)":[3],"is":[4,9],"an":[5],"acquired":[6],"thombophilia,":[7],"which":[8],"characterized":[10],"by":[11,32,68],"one":[12],"or":[13],"more":[14],"thrombotic":[15,62],"episodes":[16],"and":[17,42,63],"obstetric":[18],"complications":[19],"in":[20,61],"the":[21,52],"presence":[22],"of":[23,57],"(aPL)":[25],"antibodies":[26],"(Abs).":[27],"aPL":[28,69],"Abs":[29],"are":[30],"detected":[31],"laboratory":[33],"tests":[34],"such":[35],"as":[36],"lupus":[37],"anticoagulant":[38],"(LA),":[39],"anticardiolipin":[40],"(aCL)":[41],"anti-\ufffb":[43],"2-glycoprotein":[44],"I":[45],"(\ufffb":[46],"2GPI)":[47],"Abs.":[48],"This":[49],"article":[50],"reviews":[51],"most":[53],"current":[54],"pathophysiological":[55],"aspects":[56],"APS":[58],"with":[59],"emphasis":[60],"pro-":[64],"inflammatory":[65],"mechanisms":[66],"mediated":[67],"antibodies.":[70]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
