{"id":"https://openalex.org/W2188395147","doi":"https://doi.org/10.1042/bse0510161","title":"Trichomonas vaginalis: current understanding of host\u2013parasite interactions","display_name":"Trichomonas vaginalis: current understanding of host\u2013parasite interactions","publication_year":2011,"publication_date":"2011-10-24","ids":{"openalex":"https://openalex.org/W2188395147","doi":"https://doi.org/10.1042/bse0510161","mag":"2188395147","pmid":"https://pubmed.ncbi.nlm.nih.gov/22023448","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6445371"},"language":"en","primary_location":{"id":"doi:10.1042/bse0510161","doi":"https://doi.org/10.1042/bse0510161","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bse0510161","pdf_url":null,"source":{"id":"https://openalex.org/S30084617","display_name":"Essays in Biochemistry","issn_l":"0071-1365","issn":["0071-1365","1744-1358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Essays in Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6445371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher M. Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Ryan","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009085282","display_name":"Natalia de Miguel","orcid":"https://orcid.org/0000-0002-3864-0703","observed_orcids":["https://orcid.org/0000-0002-3864-0703"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia de Miguel","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054011186","display_name":"Patricia J. Johnson","orcid":"https://orcid.org/0000-0003-4472-2702","observed_orcids":["https://orcid.org/0000-0003-4472-2702"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia J. Johnson","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095-1489, U.S.A","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":0.6961,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.54181818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"51","issue":null,"first_page":"161","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichomonas-vaginalis","display_name":"Trichomonas vaginalis","score":1.0},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.9419999718666077},{"id":"https://openalex.org/keywords/trichomoniasis","display_name":"trichomoniasis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/parasite-adhesion","display_name":"parasite adhesion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/adhesins","display_name":"adhesins","score":0.8289999961853027},{"id":"https://openalex.org/keywords/lipophosphoglycan","display_name":"lipophosphoglycan","score":0.9929999709129333},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8629999756813049},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.7639999985694885},{"id":"https://openalex.org/keywords/surface-proteins","display_name":"surface proteins","score":0.6830000281333923},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vaccine-candidate","display_name":"vaccine candidate","score":0.8479999899864197},{"id":"https://openalex.org/keywords/urogenital-tract-infections","display_name":"urogenital infections","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2781114625","wikidata":"https://www.wikidata.org/wiki/Q132595","display_name":"Trichomonas vaginalis","level":2,"score":0.9079387187957764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7889649868011475},{"id":"https://openalex.org/C179470777","wikidata":"https://www.wikidata.org/wiki/Q356661","display_name":"Bacterial adhesin","level":4,"score":0.5650033950805664},{"id":"https://openalex.org/C99498324","wikidata":"https://www.wikidata.org/wiki/Q7075151","display_name":"Obligate parasite","level":3,"score":0.5340221524238586},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.5159743428230286},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.4814685881137848},{"id":"https://openalex.org/C2779397712","wikidata":"https://www.wikidata.org/wiki/Q309497","display_name":"Trichomonas","level":3,"score":0.43430548906326294},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37462514638900757},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.36701148748397827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30152010917663574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2655407190322876},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.2250623106956482},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08812671899795532},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006028","descriptor_name":"Glycosphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014245","descriptor_name":"Trichomonas Infections","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D014246","descriptor_name":"Trichomonas vaginalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014246","descriptor_name":"Trichomonas vaginalis","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bse0510161","doi":"https://doi.org/10.1042/bse0510161","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bse0510161","pdf_url":null,"source":{"id":"https://openalex.org/S30084617","display_name":"Essays in Biochemistry","issn_l":"0071-1365","issn":["0071-1365","1744-1358"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Essays in Biochemistry","raw_type":"journal-article"},{"id":"pmid:22023448","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22023448","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Essays in biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5431072","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6445371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6445371","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6445371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Essays Biochem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5431072","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6445371","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G874489140","display_name":"Trichomonas pathogenesis: cell surface interactions","funder_award_id":"R01AI069058","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W200903626","https://openalex.org/W1888677171","https://openalex.org/W1907742468","https://openalex.org/W1947047907","https://openalex.org/W1952053657","https://openalex.org/W1967269935","https://openalex.org/W1968835846","https://openalex.org/W1976959982","https://openalex.org/W1978227543","https://openalex.org/W1982851902","https://openalex.org/W1984888905","https://openalex.org/W1990309626","https://openalex.org/W1999222091","https://openalex.org/W2000521533","https://openalex.org/W2001216057","https://openalex.org/W2004344165","https://openalex.org/W2006722956","https://openalex.org/W2009972285","https://openalex.org/W2011499742","https://openalex.org/W2013475068","https://openalex.org/W2015928161","https://openalex.org/W2035025373","https://openalex.org/W2048811581","https://openalex.org/W2050036948","https://openalex.org/W2050496751","https://openalex.org/W2057600702","https://openalex.org/W2082694860","https://openalex.org/W2087214714","https://openalex.org/W2088417213","https://openalex.org/W2092879357","https://openalex.org/W2093020034","https://openalex.org/W2095556222","https://openalex.org/W2100727985","https://openalex.org/W2108093812","https://openalex.org/W2110649122","https://openalex.org/W2114419051","https://openalex.org/W2119462775","https://openalex.org/W2123345044","https://openalex.org/W2124063233","https://openalex.org/W2129396527","https://openalex.org/W2131481885","https://openalex.org/W2138310412","https://openalex.org/W2141170155","https://openalex.org/W2141684853","https://openalex.org/W2148537294","https://openalex.org/W2156344394","https://openalex.org/W2156798056","https://openalex.org/W2160265407","https://openalex.org/W2163524749","https://openalex.org/W2163536679","https://openalex.org/W2164453582","https://openalex.org/W2167403197","https://openalex.org/W2171120381"],"related_works":["https://openalex.org/W2811390664","https://openalex.org/W3126937727","https://openalex.org/W2345756455","https://openalex.org/W272240264","https://openalex.org/W3128191479","https://openalex.org/W2766353610","https://openalex.org/W2060462415","https://openalex.org/W2050036948","https://openalex.org/W4387873479","https://openalex.org/W4399576966"],"abstract_inverted_index":{"Trichomonas":[0,130],"vaginalis":[1,34,64,94,183],"is":[2,26,81,159],"a":[3,77,140,156],"sexually":[4],"transmitted":[5],"obligate":[6],"extracellular":[7,58],"parasite":[8,53],"that":[9,125],"colonizes":[10],"the":[11,21,29,49,52,68,74,92,98,133,169,174],"human":[12],"urogenital":[13],"tract.":[14],"Despite":[15],"being":[16],"of":[17,51,70,91,135,165,177,190],"critical":[18],"importance":[19],"to":[20,35,103,161],"parasite's":[22],"survival":[23],"relatively":[24],"little":[25],"known":[27],"about":[28],"mechanisms":[30],"employed":[31],"by":[32],"T.":[33,63,93,182],"establish":[36],"an":[37,188],"infection":[38],"and":[39,57,122,148,197],"thrive":[40],"within":[41],"its":[42,71,166],"host.":[43],"Several":[44,112],"studies":[45],"have":[46,115],"focused":[47],"on":[48],"interaction":[50],"with":[54,67],"host":[55],"cells":[56],"matrix,":[59],"identifying":[60,145],"multiple":[61],"suspected":[62],"adhesins.":[65],"However,":[66],"exception":[69],"surface":[72],"lipophosphoglycan,":[73],"evidence":[75],"supporting":[76],"role":[78],"in":[79,109,129],"adhesion":[80],"indirect":[82],"or":[83],"controversial":[84],"for":[85,100,105,139,151],"many":[86],"candidate":[87],"molecules.":[88],"The":[89],"availability":[90],"genome":[95],"sequence":[96],"paved":[97],"way":[99],"genomic":[101],"analyses":[102,114],"search":[104],"proteins":[106,124],"possibly":[107],"involved":[108,128],"host-parasite":[110],"interactions.":[111],"proteomic":[113],"also":[116],"provided":[117],"insight":[118],"into":[119],"surface,":[120],"soluble":[121],"secreted":[123],"may":[126],"be":[127],"pathogenesis.":[131,184],"Although":[132],"accumulation":[134],"molecular":[136],"data":[137],"allows":[138],"more":[141],"rational":[142],"approach":[143],"towards":[144],"drug":[146],"targets":[147],"vaccine":[149],"candidates":[150],"this":[152,195],"medically":[153],"important":[154],"parasite,":[155],"continued":[157],"effort":[158],"required":[160],"advance":[162],"our":[163],"understanding":[164,181],"biology.":[167],"In":[168],"present":[170],"chapter,":[171],"we":[172],"review":[173],"current":[175],"status":[176],"research":[178,196],"aimed":[179],"at":[180],"Applied":[185],"experimental":[186],"approaches,":[187],"overview":[189],"significant":[191],"conclusions":[192],"drawn":[193],"from":[194],"future":[198],"challenges":[199],"are":[200],"discussed.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
