{"id":"https://openalex.org/W2188389608","doi":null,"title":"Effect of Hydroalcoholic Extract of Henna (Lawsonia inermis) on Liver Enzymes and Development in Neonatal Male Rats Born from Treated Mothers","display_name":"Effect of Hydroalcoholic Extract of Henna (Lawsonia inermis) on Liver Enzymes and Development in Neonatal Male Rats Born from Treated Mothers","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2188389608","mag":"2188389608"},"language":"en","primary_location":{"id":"mag:2188389608","doi":null,"is_oa":false,"landing_page_url":"http://textroad.com/pdf/JAEBS/J.%20Appl.%20Environ.%20Biol.%20Sci.,%204(9)99-105,%202014.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081621299","display_name":"Goodarzi Farahnaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goodarzi Farahnaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103902834","display_name":"Mehrdad Shariati","orcid":"https://orcid.org/0000-0001-9441-8085","observed_orcids":["https://orcid.org/0000-0001-9441-8085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehrdad Shariati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038867124","display_name":"Mahjoor Amir Ashkan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahjoor Amir Ashkan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.225,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.47873718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.24070000648498535,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.12039999663829803,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lawsonia-inermis","display_name":"Lawsonia inermis","score":1.0},{"id":"https://openalex.org/keywords/hydroalcoholic-extract","display_name":"hydroalcoholic extract","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.722000002861023},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.5529999732971191},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.9380000233650208},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.5370000004768372},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.7319267392158508},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6949961185455322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6121867299079895},{"id":"https://openalex.org/C2909302117","wikidata":"https://www.wikidata.org/wiki/Q182448","display_name":"Lawsonia inermis","level":2,"score":0.5066105127334595},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.437975138425827},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4374108910560608},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4345182478427887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38182467222213745},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.373715341091156},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.260439395904541}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188389608","doi":null,"is_oa":false,"landing_page_url":"http://textroad.com/pdf/JAEBS/J.%20Appl.%20Environ.%20Biol.%20Sci.,%204(9)99-105,%202014.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W31446808","https://openalex.org/W1546748767","https://openalex.org/W1567725518","https://openalex.org/W1642570757","https://openalex.org/W1810432121","https://openalex.org/W1912855510","https://openalex.org/W1964835867","https://openalex.org/W1973990109","https://openalex.org/W1977750053","https://openalex.org/W1978483090","https://openalex.org/W1979182110","https://openalex.org/W1979849395","https://openalex.org/W1980248989","https://openalex.org/W1987098043","https://openalex.org/W1990010616","https://openalex.org/W2005590745","https://openalex.org/W2019695222","https://openalex.org/W2021056604","https://openalex.org/W2049923191","https://openalex.org/W2089293776","https://openalex.org/W2099680167","https://openalex.org/W2131878763","https://openalex.org/W2137330089","https://openalex.org/W2150835916","https://openalex.org/W2151001012","https://openalex.org/W2165201727","https://openalex.org/W2244693345","https://openalex.org/W2316560834","https://openalex.org/W2320674879","https://openalex.org/W2321700180","https://openalex.org/W2343963060","https://openalex.org/W2977621272"],"related_works":["https://openalex.org/W2228381376","https://openalex.org/W2603849050","https://openalex.org/W7217211646","https://openalex.org/W4245867919","https://openalex.org/W2972413279","https://openalex.org/W640784814","https://openalex.org/W2609562576","https://openalex.org/W2980475388","https://openalex.org/W1536372387","https://openalex.org/W2794795054"],"abstract_inverted_index":{"Introduction":[0],"and":[1,17,21,55,59,67,106,112,127,133,149,171,177,199,233,250],"purpose:":[2],"Considering":[3],"the":[4,8,42,50,100,116,123,144,181,186,206],"important":[5],"role":[6],"of":[7,14,25,40,44,47,52,61,85,94,99,118,129,146,159,222,230,242],"liver":[9,53,130,165,197,221,237,249],"in":[10,29,107,164,180,185,205,220,236,246,267],"relation":[11],"to":[12],"metabolism":[13],"chemical":[15],"composition":[16],"plasma":[18],"protein":[19,134],"synthesis":[20],"also":[22],"excessive":[23],"use":[24],"herbs":[26],"(medicinal":[27],"plants)":[28],"traditional":[30],"medicine,":[31],"particularly":[32],"Hanna;":[33],"current":[34],"study":[35,264],"was":[36,139,178,202,213],"conducted":[37],"with":[38,151,258],"purpose":[39],"investigating":[41],"effects":[43],"hydroalcoholic":[45,157,240],"extracts":[46,158,241],"henna":[48,101,160,226,243],"on":[49],"activity":[51],"enzymes":[54,166],"blood":[56],"biochemical":[57],"factors":[58],"development":[60],"neonatal":[62,121],"male":[63,74],"mouse":[64],"liver.":[65],"Material":[66],"methods:":[68],"In":[69],"this":[70,173,253,268],"experimental":[71,108],"study,":[72],"40":[73],"Wistar":[75],"rat":[76],"were":[77,80,125,135],"participated,":[78],"they":[79],"divided":[81],"into":[82],"5":[83],"groups":[84,109,183,208,223],"8":[86],"mothers":[87],"who":[88],"had":[89],"previously":[90],"received":[91],"specific":[92],"doses":[93],"100,":[95],"200,":[96],"400":[97],"mg":[98],"extract":[102],"during":[103,260],"their":[104],"pregnancy":[105],"1,":[110],"2":[111],"3":[113],"respectively.":[114],"After":[115],"end":[117],"22":[119],"days":[120],"period,":[122],"rats":[124],"weighed":[126],"assessment":[128],"enzymes,":[131],"albumin":[132,200],"performed.":[136],"Histological":[137],"examination":[138],"performed":[140],"after":[141],"preprocessing":[142],"through":[143],"steps":[145],"slicing,":[147],"smears":[148],"staining":[150],"hematoxylin":[152],"-":[153],"eosin.":[154],"Results:":[155],"The":[156],"caused":[161],"significant":[162,204],"increase":[163,174],"including":[167],"ALP,":[168],"AST,":[169],"ALT":[170],"protein,":[172],"is":[175,265],"dose-dependent":[176],"observed":[179],"treatment":[182,207],"than":[184,209],"control":[187,210],"group(p<0.05).":[188],"However,":[189],"other":[190],"variables":[191],"such":[192],"as":[193],"infants":[194],"birth":[195],"weight,":[196,198],"level":[201],"not":[203],"group.":[211],"There":[212],"mild,":[214],"moderate":[215],"or":[216],"severe":[217],"pathologic":[218],"changes":[219,235],"whom":[224],"receiving":[225],"extract.":[227],"Conclusion:":[228],"Results":[229],"enzyme":[231],"tests":[232],"histopathological":[234],"shown":[238],"that":[239,252],"cause":[244],"damage":[245],"newborn":[247],"mice":[248],"suggesting":[251],"herb":[254],"should":[255],"be":[256],"used":[257],"caution":[259],"pregnancy,":[261],"although":[262],"more":[263],"needed":[266],"area.":[269]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}