{"id":"https://openalex.org/W2188380591","doi":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","title":"Impact of development and chronic hypoxia on NE release from adrenergic nerves in sheep arteries","display_name":"Impact of development and chronic hypoxia on NE release from adrenergic nerves in sheep arteries","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W2188380591","doi":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","mag":"2188380591","pmid":"https://pubmed.ncbi.nlm.nih.gov/10070141"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1999.276.3.r799","doi":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082552875","display_name":"John N. Buchholz","orcid":"https://orcid.org/0000-0002-8356-3831","observed_orcids":["https://orcid.org/0000-0002-8356-3831"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Buchholz","raw_affiliation_strings":["Department of Pharmacology and Physiology, School of Medicine, Loma Linda University, Loma Linda 92350;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, School of Medicine, Loma Linda University, Loma Linda 92350;","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040139259","display_name":"Kim Edwards-Teunissen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kim Edwards-Teunissen","raw_affiliation_strings":["Catholic University of Nijmegen, Sophiaweg 104, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catholic University of Nijmegen, Sophiaweg 104, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108403639","display_name":"SUE PIPER DUCKLES","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue P. Duckles","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of California, Irvine, California 92697; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of California, Irvine, California 92697; and","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5285,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.67524034,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"276","issue":"3","first_page":"R799","last_page":"R808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":0.9150000214576721},{"id":"https://openalex.org/keywords/adrenergic-nerves","display_name":"adrenergic nerves","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chronic-hypoxia","display_name":"chronic hypoxia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/high-altitude-hypoxia","display_name":"high-altitude hypoxia","score":0.8379999995231628},{"id":"https://openalex.org/keywords/sympathetic-nerve-function","display_name":"sympathetic function","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8700000047683716},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"middle cerebral artery","score":0.7170000076293945},{"id":"https://openalex.org/keywords/facial-artery","display_name":"facial artery","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fetal-development","display_name":"fetal development","score":0.6959999799728394},{"id":"https://openalex.org/keywords/capsaicin-sensitive-nerves","display_name":"capsaicin-sensitive sensory nerves","score":0.8140000104904175},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sheep","display_name":"sheep","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6926421523094177},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.6490079164505005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4417183995246887},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.39736369252204895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37563779950141907},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3555935025215149},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34804028272628784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2434244155883789},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20009097456932068},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.050725728273391724},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000320","descriptor_name":"Adrenergic Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1999.276.3.r799","doi":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1999.276.3.r799","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:10070141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10070141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6126536748","display_name":" (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION:  FETUS AND ADULT","funder_award_id":"P01HD031226","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1602635229","https://openalex.org/W1664364888","https://openalex.org/W1900936146","https://openalex.org/W1932483871","https://openalex.org/W1944438626","https://openalex.org/W1970934194","https://openalex.org/W1978433770","https://openalex.org/W1982330830","https://openalex.org/W1990736091","https://openalex.org/W2002318487","https://openalex.org/W2019969634","https://openalex.org/W2027478234","https://openalex.org/W2030508131","https://openalex.org/W2034572815","https://openalex.org/W2042102833","https://openalex.org/W2047449662","https://openalex.org/W2049863374","https://openalex.org/W2066625747","https://openalex.org/W2072106047","https://openalex.org/W2072179174","https://openalex.org/W2072335614","https://openalex.org/W2080019016","https://openalex.org/W2092635728","https://openalex.org/W2095498092","https://openalex.org/W2096873942","https://openalex.org/W2112341090","https://openalex.org/W2136687023","https://openalex.org/W2160172740","https://openalex.org/W2175719463","https://openalex.org/W2229217375","https://openalex.org/W2239308086","https://openalex.org/W2263333154","https://openalex.org/W2269726330","https://openalex.org/W2273526695","https://openalex.org/W2284688935","https://openalex.org/W2285462875","https://openalex.org/W2298233501","https://openalex.org/W2336301891","https://openalex.org/W2409924846","https://openalex.org/W2437980787","https://openalex.org/W2461783448"],"related_works":["https://openalex.org/W2160594404","https://openalex.org/W2279962611","https://openalex.org/W2052177106","https://openalex.org/W3175338241","https://openalex.org/W1531391921","https://openalex.org/W6991942657","https://openalex.org/W993409806","https://openalex.org/W2284688935","https://openalex.org/W2162754124","https://openalex.org/W2027006963"],"abstract_inverted_index":{"To":[0],"examine":[1],"effects":[2,96],"of":[3,34,52,84,93,97,173,179,190],"development":[4],"and":[5,24,157],"chronic":[6,89,106,125,150,180],"high-altitude":[7],"hypoxia":[8,115,126,151,181],"on":[9],"sympathetic":[10],"nerve":[11],"function":[12,83],"in":[13,19,59,69,128,131,140,154,163,170,176],"sheep,":[14],"norepinephrine":[15,38,57,79,101,119,133],"release":[16,39,58,102],"was":[17,28,40,103,137],"measured":[18],"vitro":[20],"from":[21,63],"middle":[22,60,110],"cerebral":[23,61,111,156],"facial":[25,73,123,143,158],"arteries.":[26,74,159],"Capsaicin":[27],"used":[29],"to":[30,114,149,187],"test":[31],"the":[32,82,94,141,146,177],"role":[33],"capsaicin-sensitive":[35],"sensory":[36],"nerves;":[37],"not":[41],"altered":[42],"by":[43,116],"capsaicin":[44],"treatment.":[45],"Nomega-nitro-L-arginine":[46],"methyl":[47],"ester":[48],"(L-NAME),":[49],"an":[50,138],"inhibitor":[51],"NO":[53],"synthase,":[54],"decreased":[55],"stimulation-evoked":[56,99,118,132],"arteries":[62,71,112],"normoxic":[64],"sheep":[65],"with":[66],"no":[67],"effect":[68],"hypoxic":[70],"or":[72],"Thus":[75],"NO-releasing":[76,85],"nerves":[77,86,166],"augmented":[78],"release.":[80,120],"Furthermore,":[81],"declined":[87],"after":[88,105],"hypoxia.":[90],"Despite":[91],"loss":[92],"augmenting":[95],"NO,":[98],"fractional":[100],"unchanged":[104],"hypoxia,":[107],"suggesting":[108],"that":[109],"adapt":[113],"increasing":[117],"In":[121,145],"fetal":[122,164,171,191],"arteries,":[124],"resulted":[127],"a":[129],"decline":[130],"release,":[134],"but":[135,182],"there":[136],"increase":[139],"adult":[142],"artery.":[144],"adult,":[147],"adaptation":[148,162],"is":[152],"similar":[153],"both":[155],"However,":[160],"differential":[161],"adrenergic":[165],"may":[167],"reflect":[168],"differences":[169],"redistribution":[172],"blood":[174],"flow":[175],"face":[178],"could":[183],"also":[184],"possibly":[185],"contribute":[186],"increased":[188],"incidence":[189],"morbidity.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}