{"id":"https://openalex.org/W2188373664","doi":null,"title":"The influence of low-dose atorvastatin on lipid levels and endothelial vascular function in patients with significant coronary artery stenosis.","display_name":"The influence of low-dose atorvastatin on lipid levels and endothelial vascular function in patients with significant coronary artery stenosis.","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2188373664","mag":"2188373664","pmid":"https://pubmed.ncbi.nlm.nih.gov/16444629"},"language":"en","primary_location":{"id":"pmid:16444629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16444629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kardiologia polska","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086196552","display_name":"Olexandr V. Kuryata","orcid":"https://orcid.org/0000-0001-7642-0077","observed_orcids":["https://orcid.org/0000-0001-7642-0077"]},"institutions":[{"id":"https://openalex.org/I905458539","display_name":"Dnipro State Medical University","ror":"https://ror.org/0469ncz24","country_code":"UA","type":"healthcare","lineage":["https://openalex.org/I905458539"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Olexandr V Kuryata","raw_affiliation_strings":["1st Department of Hospital Therapy, State Medical Academy, ul. Dzerzynski 9, Dnepropetrovsk 49000, Ukraine. gt1@dsma.dp.ua","1st Department of Hospital Therapy, State Medical Academy, ul. Dzerzynski 9, Dnepropetrovsk 49000, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1st Department of Hospital Therapy, State Medical Academy, ul. Dzerzynski 9, Dnepropetrovsk 49000, Ukraine. gt1@dsma.dp.ua","institution_ids":["https://openalex.org/I905458539"]},{"raw_affiliation_string":"1st Department of Hospital Therapy, State Medical Academy, ul. Dzerzynski 9, Dnepropetrovsk 49000, Ukraine","institution_ids":["https://openalex.org/I905458539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052904374","display_name":"Y.V. Yegorova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulia V Yegorova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6782,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73835537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"64","issue":"1","first_page":"44","last_page":"8; discussion 49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/low-dose-statin-therapy","display_name":"low-dose statin therapy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/stable-angina","display_name":"stable angina","score":0.8330000042915344},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7009999752044678},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9120000004768372},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.996999979019165},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9369999766349792},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/brachial-artery","display_name":"brachial artery","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.946918249130249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9433308243751526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7040743231773376},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6608222723007202},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6558213829994202},{"id":"https://openalex.org/C2777604165","wikidata":"https://www.wikidata.org/wiki/Q503643","display_name":"Brachial artery","level":3,"score":0.5541834831237793},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5176832675933838},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.4820367097854614},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4736058712005615},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4600174129009247},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4475817382335663},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.4408465325832367},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4353835880756378},{"id":"https://openalex.org/C2993958921","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Stable angina","level":3,"score":0.42353346943855286},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2023726999759674}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023921","descriptor_name":"Coronary Stenosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D023921","descriptor_name":"Coronary Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16444629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16444629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kardiologia polska","raw_type":"Journal Article"},{"id":"mag:2188373664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16444629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1987054189","https://openalex.org/W1997007231","https://openalex.org/W2004878568","https://openalex.org/W2031185570","https://openalex.org/W2033053171","https://openalex.org/W2063784817","https://openalex.org/W2107295258","https://openalex.org/W2144437066","https://openalex.org/W2145653235","https://openalex.org/W2159449551","https://openalex.org/W2160152341","https://openalex.org/W2315638360","https://openalex.org/W2398705215"],"related_works":["https://openalex.org/W2064903649","https://openalex.org/W2348968604","https://openalex.org/W7097143964","https://openalex.org/W2369102341","https://openalex.org/W4319261892","https://openalex.org/W2165674458","https://openalex.org/W2597614540","https://openalex.org/W4200172817","https://openalex.org/W2383685979","https://openalex.org/W2901795768"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hyperlipidaemia":[1],"is":[2,219,226],"a":[3,48,80],"well-established":[4],"risk":[5],"factor":[6],"of":[7,10,47,65,75,125,198,203,231],"the":[8,45,126,141,146,156,229],"progression":[9],"coronary":[11,76],"artery":[12,128],"disease":[13],"(CAD).":[14],"Statins":[15],"such":[16],"as":[17,19],"atorvastatin,":[18],"lipid-lowering":[20],"agents,":[21],"can":[22],"not":[23],"only":[24],"normalise":[25],"serum":[26],"lipid":[27],"levels,":[28],"but":[29],"also":[30],"may":[31],"improve":[32],"endothelial":[33,232],"function,":[34],"reduce":[35],"vascular":[36],"inflammation":[37],"and":[38,71,103,110,121,132,152,180,194,225],"enhance":[39],"plaque":[40],"stability.":[41],"AIM:":[42],"To":[43],"evaluate":[44],"efficacy":[46],"low-dose":[49],"atorvastatin":[50,85,215],"regimen":[51],"(10":[52,216],"mg":[53,217],"daily)":[54,218],"in":[55,140,143,153,196,221,234],"patients":[56,61,138,199,235],"with":[57,62,84,214,228,236],"CAD.":[58,237],"METHODS:":[59],"Seventy-nine":[60],"stable":[63],"angina":[64],"II":[66],"or":[67],"III":[68],"functional":[69],"class":[70],"angiographically":[72],"significant":[73],"stenosis":[74],"arteries":[77],"(>70%)":[78],"entered":[79],"12-week":[81],"treatment":[82,112,213],"period":[83],"10":[86],"mg/day.":[87],"Lipid":[88],"profile,":[89],"which":[90],"included":[91,139],"total":[92],"cholesterol":[93,97,101],"(TC),":[94],"low-density":[95],"lipoprotein":[96,100],"(LDL-C),":[98],"high-density":[99],"(HDL-C)":[102],"triglycerides":[104],"(TG)":[105],"were":[106,129,161],"assessed":[107],"at":[108,113],"baseline":[109],"after":[111,133,200],"week":[114],"12.":[115],"In":[116],"addition,":[117],"flow-mediated":[118],"vasodilatation":[119],"(FMD)":[120],"nitrate-induced":[122],"dilation":[123],"(NID)":[124],"brachial":[127],"measured":[130],"before":[131],"treatment.":[134],"RESULTS:":[135],"Among":[136],"79":[137],"study,":[142],"54":[144],"(68%)":[145],"target":[147],"TC":[148,165],"value":[149],"<5.0":[150],"mmol/l,":[151],"51":[154],"(65%)":[155],"LDL-C":[157,170],"level":[158,166,171,176,183],"<3.0":[159],"mmol/l":[160],"achieved.":[162],"Atorvastatin":[163],"decreased":[164],"by":[167,172,177,184,190,208],"31%":[168],"(p<0.01),":[169,174],"35%":[173],"TG":[175],"23%":[178],"(p<0.01)":[179,193],"increased":[181,189,207],"HDL-C":[182],"8%":[185],"(p<0.01).":[186],"FMD":[187],"was":[188,206],"61":[191],"%":[192],"normalised":[195],"88%":[197],"3-month":[201],"therapy":[202],"atorvastatin.":[204],"NID":[205],"16%":[209],"(p<0.05).":[210],"CONCLUSION:":[211],"Low-dose":[212],"effective":[220],"reducing":[222],"blood":[223],"lipids":[224],"associated":[227],"improvement":[230],"function":[233]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
