{"id":"https://openalex.org/W2188328095","doi":"https://doi.org/10.1164/arrd.1987.135.3.554","title":"Bronchoalveolar lavage does not alter airway responsiveness in asthmatic subjects.","display_name":"Bronchoalveolar lavage does not alter airway responsiveness in asthmatic subjects.","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2188328095","doi":"https://doi.org/10.1164/arrd.1987.135.3.554","mag":"2188328095","pmid":"https://pubmed.ncbi.nlm.nih.gov/3548505"},"language":"en","primary_location":{"id":"pmid:3548505","doi":"https://doi.org/10.1164/arrd.1987.135.3.554","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3548505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019040547","display_name":"John G. Kirby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J G Kirby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026242254","display_name":"Paul M. O\u2019Byrne","orcid":"https://orcid.org/0000-0003-0979-281X","observed_orcids":["https://orcid.org/0000-0003-0979-281X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M O'Byrne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113644570","display_name":"FREDERICK E. HARGREAVE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F E Hargreave","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9751,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.86324174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"3","first_page":"554","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.8040000200271606},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7649999856948853},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.8560000061988831},{"id":"https://openalex.org/keywords/bronchoscopy-safety","display_name":"bronchoscopy safety","score":0.6729999780654907},{"id":"https://openalex.org/keywords/airway-narrowing","display_name":"airway narrowing","score":0.6119999885559082},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/lavage-volume","display_name":"lavage volume","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2781260171","wikidata":"https://www.wikidata.org/wiki/Q413188","display_name":"Methacholine","level":4,"score":0.9480048418045044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9451119899749756},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.9233707189559937},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.76581871509552},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7075467705726624},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6458680033683777},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.5741977691650391},{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.5131112337112427},{"id":"https://openalex.org/C2778996910","wikidata":"https://www.wikidata.org/wiki/Q237232","display_name":"Bronchoscopy","level":2,"score":0.42971986532211304},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2852274775505066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2634052634239197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22613024711608887},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.19971707463264465}],"mesh":[{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001985","descriptor_name":"Bronchial Provocation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007507","descriptor_name":"Therapeutic Irrigation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008688","descriptor_name":"Methacholine Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3548505","doi":"https://doi.org/10.1164/arrd.1987.135.3.554","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3548505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"mag:2188328095","doi":"https://doi.org/10.1164/arrd.1987.135.3.554","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3548505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1909282225","https://openalex.org/W1936301711","https://openalex.org/W1948079963","https://openalex.org/W1975790353","https://openalex.org/W1987674391","https://openalex.org/W1992376271","https://openalex.org/W2012412421","https://openalex.org/W2071754888","https://openalex.org/W2078571876","https://openalex.org/W2164746237","https://openalex.org/W2497867324"],"related_works":["https://openalex.org/W2093787128","https://openalex.org/W2131129415","https://openalex.org/W2169476910","https://openalex.org/W2057585969","https://openalex.org/W2069645388","https://openalex.org/W2124025090","https://openalex.org/W2151235746","https://openalex.org/W2331885588","https://openalex.org/W7100433298","https://openalex.org/W2009689913"],"abstract_inverted_index":{"Bronchoalveolar":[0],"lavage":[1,111],"(BAL)":[2],"during":[3],"fiberoptic":[4],"bronchoscopy":[5],"is":[6,19],"being":[7],"used":[8,103],"increasingly":[9],"for":[10,104],"the":[11,24,33,72,93,98,108,125,131,141],"investigation":[12],"of":[13,23,28,35,64,95,100,110,116,119,127,140,143],"asthma.":[14,29],"Airway":[15],"responsiveness":[16,40,123],"to":[17,77],"methacholine":[18,38,46],"a":[20],"sensitive":[21],"indicator":[22],"presence":[25],"and":[26,52,97],"severity":[27],"Therefore,":[30],"we":[31],"studied":[32],"effect":[34,118],"BAL":[36,56,68,120],"on":[37,121],"airway":[39,65,122,145],"in":[41,60,71,130],"stable":[42],"asthmatics.":[43,61],"Geometric":[44],"mean":[45],"PC20":[47],"was":[48,89],"1.34":[49],"mg/ml":[50,54],"before":[51],"1.80":[53],"after":[55,67],"(p":[57],"=":[58],"0.26)":[59],"Immediate":[62],"symptoms":[63,81,96],"narrowing":[66],"occurred":[69],"only":[70],"3":[73],"asthmatics":[74],"with":[75,135],"moderate":[76],"severe":[78],"hyperresponsiveness.":[79],"These":[80],"were":[82],"rapidly":[83],"relieved":[84],"by":[85],"inhaled":[86],"bronchodilator.":[87],"There":[88],"no":[90],"relationship":[91],"between":[92],"occurrence":[94],"amount":[99],"topical":[101],"lidocaine":[102],"local":[105],"anaesthesia":[106],"or":[107],"volume":[109],"fluid":[112],"returned.":[113],"The":[114],"absence":[115],"an":[117],"supports":[124],"safety":[126],"this":[128],"procedure":[129],"controlled":[132],"asthmatic":[133],"patient":[134],"near":[136],"normal":[137],"FEV1,":[138],"irrespective":[139],"level":[142],"baseline":[144],"responsiveness.":[146]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}