{"id":"https://openalex.org/W2188315035","doi":null,"title":"BRAIN TUMOURS: SUCCESSES AND CHALLENGES ON THE OTHER SIDE OF THE BLOOD-BRAIN BARRIER","display_name":"BRAIN TUMOURS: SUCCESSES AND CHALLENGES ON THE OTHER SIDE OF THE BLOOD-BRAIN BARRIER","publication_year":2015,"publication_date":"2015-03-01","ids":{"openalex":"https://openalex.org/W2188315035","mag":"2188315035"},"language":"en","primary_location":{"id":"mag:2188315035","doi":null,"is_oa":false,"landing_page_url":"http://cancerforum.org.au/wp-content/uploads/2015/06/7.Brain-tumours-successes-and-challenges.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306505627","display_name":"Cancer Forum","issn_l":"0311-306X","issn":["0311-306X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Forum","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056506870","display_name":"Kathryn Maree Field","orcid":"https://orcid.org/0000-0003-2588-2233","observed_orcids":["https://orcid.org/0000-0003-2588-2233"]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Field","raw_affiliation_strings":["Royal Melbourne Hospital"],"raw_orcid":"https://orcid.org/0000-0003-2588-2233","affiliations":[{"raw_affiliation_string":"Royal Melbourne Hospital","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010759705","display_name":"Mark Andrew Rosenthal","orcid":"https://orcid.org/0000-0003-1152-6764","observed_orcids":["https://orcid.org/0000-0003-1152-6764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Rosenthal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1152-6764","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1499,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.51658487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"1","first_page":"24","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9409999847412109},{"id":"https://openalex.org/keywords/central-nervous-system-malignancies","display_name":"central nervous system malignancies","score":0.8730000257492065},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.8270000219345093},{"id":"https://openalex.org/keywords/molecular-properties","display_name":"molecular properties","score":0.5130000114440918},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rare-tumor","display_name":"rare tumor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/treatment-challenges","display_name":"treatment challenges","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6376407146453857},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5815651416778564},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5662806630134583},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.543655276298523},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5128607749938965},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46867188811302185},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46843868494033813},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35847610235214233},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3365952968597412},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23703187704086304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20404109358787537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08860090374946594},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2188315035","doi":null,"is_oa":false,"landing_page_url":"http://cancerforum.org.au/wp-content/uploads/2015/06/7.Brain-tumours-successes-and-challenges.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306505627","display_name":"Cancer Forum","issn_l":"0311-306X","issn":["0311-306X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Forum","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W618788809","https://openalex.org/W1973303804","https://openalex.org/W1973623402","https://openalex.org/W1987868930","https://openalex.org/W1993605227","https://openalex.org/W2000233710","https://openalex.org/W2013219708","https://openalex.org/W2021227540","https://openalex.org/W2058193921","https://openalex.org/W2066343654","https://openalex.org/W2066536789","https://openalex.org/W2084945856","https://openalex.org/W2093477337","https://openalex.org/W2096287682","https://openalex.org/W2105100844","https://openalex.org/W2106824860","https://openalex.org/W2110141559","https://openalex.org/W2111139469","https://openalex.org/W2112852909","https://openalex.org/W2117321545","https://openalex.org/W2121933361","https://openalex.org/W2124736921","https://openalex.org/W2126817554","https://openalex.org/W2127972109","https://openalex.org/W2133865472","https://openalex.org/W2143078369","https://openalex.org/W2144482470","https://openalex.org/W2146729334","https://openalex.org/W2147013683","https://openalex.org/W2147482980","https://openalex.org/W2148977460","https://openalex.org/W2155677253","https://openalex.org/W2156330848","https://openalex.org/W2160959204","https://openalex.org/W2171074831","https://openalex.org/W2461273419","https://openalex.org/W2564310149","https://openalex.org/W2603438946"],"related_works":["https://openalex.org/W4318595838","https://openalex.org/W2584125249","https://openalex.org/W6946337083","https://openalex.org/W2040483402","https://openalex.org/W2188380667","https://openalex.org/W2120188435","https://openalex.org/W7172119691","https://openalex.org/W3013843293","https://openalex.org/W4250899941","https://openalex.org/W2185859568"],"abstract_inverted_index":{"Tumours":[0],"of":[1,10,44,64,111,122],"the":[2,62,81,86],"central":[3,23],"nervous":[4,24],"system":[5,25],"encompass":[6],"a":[7,48,68,112],"large":[8],"variety":[9],"cancers,":[11],"ranging":[12],"from":[13,67,72],"slow-growing":[14],"to":[15,151],"rapidly":[16],"progressive.":[17],"Although":[18],"comparatively":[19],"rare":[20,140],"in":[21,30,37,101,139],"adults,":[22,35],"malignancies":[26],"are":[27],"relatively":[28],"common":[29],"children,":[31],"adolescents":[32],"and":[33,39,47,53,59,100],"young":[34],"resulting":[36],"substantial":[38],"ongoing":[40],"morbidity,":[41],"significant":[42],"loss":[43],"effective":[45],"life-years":[46],"heavy":[49],"burden":[50],"on":[51,80,96],"family":[52],"carers.":[54],"In":[55],"fact,":[56],"more":[57],"children":[58],"adults":[60],"under":[61],"age":[63],"40":[65],"die":[66],"brain":[69,98],"tumour":[70],"than":[71,85],"any":[73],"other":[74],"cancer.":[75],"As":[76],"such,":[77],"their":[78],"effect":[79],"community":[82],"is":[83,105,108,149],"greater":[84],"apparent":[87],"low":[88],"incidence":[89],"would":[90],"otherwise":[91],"indicate.":[92],"This":[93],"article":[94],"focuses":[95],"adult":[97],"tumours":[99,141],"particular":[102],"glioblastoma.":[103],"Glioblastoma":[104],"rare,":[106],"but":[107],"an":[109],"example":[110],"disease":[113],"where":[114,142],"treatment":[115],"has":[116],"been":[117],"improved":[118],"through":[119,129],"better":[120],"understanding":[121],"its":[123],"molecular":[124],"characteristics,":[125],"as":[126,128],"well":[127],"international":[130],"clinical":[131],"trials.":[132],"We":[133],"will":[134],"also":[135],"discuss":[136],"some":[137],"challenges":[138],"level":[143],"one":[144],"evidence":[145],"for":[146],"optimal":[147],"management":[148],"unlikely":[150],"ever":[152],"exist.":[153]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}